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Ligand-induced monoubiquitination of BIK1 regulates plant immunity 期刊论文
NATURE, 2020, 581 (7807) : 199-+
作者:  Shao, Wei;  Yang, Jiajun;  He, Ming;  Yu, Xiang-Yu;  Lee, Choong Heon;  Yang, Zhaohui;  Joyner, Alexandra L.;  Anderson, Kathryn V.;  Zhang, Jiangyang;  Tsou, Meng-Fu Bryan;  Shi, Hang;  Shi, Song-Hai
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

Recognition of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) triggers the first line of inducible defence against invading pathogens(1-3). Receptor-like cytoplasmic kinases (RLCKs) are convergent regulators that associate with multiple PRRs in plants(4). The mechanisms that underlie the activation of RLCKs are unclear. Here we show that when MAMPs are detected, the RLCK BOTRYTIS-INDUCED KINASE 1 (BIK1) is monoubiquitinated following phosphorylation, then released from the flagellin receptor FLAGELLIN SENSING 2 (FLS2)-BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) complex, and internalized dynamically into endocytic compartments. The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the monoubiquitination of BIK1, which is essential for the subsequent release of BIK1 from the FLS2-BAK1 complex and activation of immune signalling. Ligand-induced monoubiquitination and endosomal puncta of BIK1 exhibit spatial and temporal dynamics that are distinct from those of the PRR FLS2. Our study reveals the intertwined regulation of PRR-RLCK complex activation by protein phosphorylation and ubiquitination, and shows that ligand-induced monoubiquitination contributes to the release of BIK1 family RLCKs from the PRR complex and activation of PRR signalling.


  
Modelling inducible defences in predator-prey interactions: assumptions and dynamical consequences of three distinct approaches 期刊论文
ECOLOGY LETTERS, 2019, 22 (2) : 390-404
作者:  Yamamichi, Masato;  Klauschies, Toni;  Miner, Brooks E.;  van Velzen, Ellen
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Adaptive dynamics  fitness gradient  inducible defence  optimal trait  phenotypic plasticity  predator-prey dynamics  reaction norm  switching function