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A GPR174-CCL21 module imparts sexual dimorphism to humoral immunity 期刊论文
NATURE, 2020, 577 (7790) : 416-+
作者:  Morley, Jessica;  Cowls, Josh;  Taddeo, Mariarosaria;  Floridi, Luciano
收藏  |  浏览/下载:16/0  |  提交时间:2020/07/03

Humoral immune responses to immunization and infection and susceptibilities to antibody-mediated autoimmunity are generally lower in males(1-3). However, the mechanisms underlying such sexual dimorphism are not well understood. Here we show that there are intrinsic differences between the B cells that produce germinal centres in male and female mice. We find that antigen-activated male B cells do not position themselves as efficiently as female B cells in the centre of follicles in secondary lymphoid organs, in which germinal centres normally develop. Moreover, GPR174-an X-chromosome-encoded G-protein-coupled receptor-suppresses the formation of germinal centres in male, but not female, mice. This effect is intrinsic to B cells, and correlates with the GPR174-enhanced positioning of B cells towards the T-cell-B-cell border of follicles, and the distraction of male, but not female, B cells from S1PR2-driven follicle-centre localization. Biochemical fractionation of conditioned media that induce B-cell migration in a GPR174-dependent manner identifies CCL21 as a GPR174 ligand. In response to CCL21, GPR174 triggers a calcium flux and preferentially induces the migration of male B cells  GPR174 also becomes associated with more G alpha i protein in male than in female B cells. Male B cells from orchidectomized mice exhibit impaired GPR174-mediated migration to CCL21, and testosterone treatment rescues this defect. Female B cells from testosterone-treated mice exhibit male-like GPR174-G alpha i association and GPR174-mediated migration. Deleting GPR174 from male B cells causes more efficient positioning towards the follicular centre, the formation of more germinal centres and an increased susceptibility to B-cell-dependent experimental autoimmune encephalomyelitis. By identifying GPR174 as a receptor for CCL21 and demonstrating its sex-dependent control of B-cell positioning and participation in germinal centres, we have revealed a mechanism by which B-cell physiology is fine-tuned to impart sexual dimorphism to humoral immunity.


  
Forest cover effects of payments for ecosystem services: Evidence from an impact evaluation in Brazil 期刊论文
ECOLOGICAL ECONOMICS, 2020, 169
作者:  Fiorini, Ana Carolina Oliveira;  Mullally, Conner;  Swisher, Marilyn;  Putz, Francis E.
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Ecosystem services  Reforestation  Watershed  Impact assessment  Participation  Brazil  Atlantic Forest  
Mechanisms behind concurrent payments for ecosystem services in a Chinese nature reserve 期刊论文
ECOLOGICAL ECONOMICS, 2020, 169
作者:  Yost, Alexandra;  An, Li;  Bilsborrow, Richard;  Shi, Lei;  Chen, Xiaodong;  Yang, Shuang;  Zhang, Weiyong
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
Concurrent payments for ecosystem services  Grain-to-green program  Post-participation behavior  China  Afforestation  Land use  
"Youth is not a political position": Exploring justice claims-making in the UN Climate Change Negotiations 期刊论文
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS, 2020, 61
作者:  Thew, Harriet;  Middlemiss, Lucie;  Paavola, Jouni
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/02
Youth  Climate Change  Participation  Recognition  Environmental Justice  Power  
Beyond participation: when citizen engagement leads to undesirable outcomes for nature-based solutions and climate change adaptation 期刊论文
CLIMATIC CHANGE, 2019
作者:  Wamsler, C.;  Alkan-Olsson, J.;  Bjorn, H.;  Falck, H.;  Hanson, H.;  Oskarsson, T.;  Simonsson, E.;  Zelmerlow, F.
收藏  |  浏览/下载:7/0  |  提交时间:2020/02/17
Nature-based solutions  Ecosystem services  Ecosystem-based adaptation  Ecosystem-based planning  Emotions  Climate change adaptation  Disaster risk reduction  Citizen participation  Collaborative governance  Sustainability  Co-Production  Citizen science  Values  Citizen engagement  Public participation  
Reassembling Lesseps Square, Rethinking Barcelona: A More-than-Human Approach 期刊论文
INTERNATIONAL JOURNAL OF URBAN AND REGIONAL RESEARCH, 2019, 43 (6) : 1123-1146
作者:  Estevez, Brais
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
assemblage urbanism  Barcelona  Spain  planning  public space  distribution of the sensible  participation  urban controversies  
What drives public willingness to participate in the voluntary personal carbon-trading scheme? A case study of Guangzhou Pilot, China 期刊论文
ECOLOGICAL ECONOMICS, 2019, 165
作者:  Tan, Xueping;  Wang, Xinyu;  Zaidi, Syed Haider Ali
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Personal Carbon Trading  Carbon Generalized System of Preferences  Technology Acceptance Model  Structural Equation Model  Participation Willingness  Climate Change  
Policy improvements and farmers' willingness to participate: Insights from the new round of China's Sloping Land Conversion Program 期刊论文
ECOLOGICAL ECONOMICS, 2019, 162: 121-132
作者:  Zhang, Zhaohui;  Paudel, Krishna P.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Sloping Land Conversion Program  Policy improvement  Participation willingness  Influencing factors  
Smart gridlock? Challenging hegemonic framings of mitigation solutions and scalability 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (7)
作者:  Sareen, Siddharth;  Rommetveit, Kjetil
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
smart grids  living labs  scaling up  participation  social imaginaries  Norway  
The impact of the policy and behavior of public participation on environmental governance performance: Empirical analysis based on provincial panel data in China 期刊论文
ENERGY POLICY, 2019, 129: 1347-1354
作者:  Zhang, Guoxing;  Deng, Nana;  Mou, Haizhen;  Zhang, Zhe George;  Chen, Xiaofeng
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/26
Public environmental participation policy  Public participation behavior  Policy quantification  Environmental governance