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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model 期刊论文
Science, 2021
作者:  Jingxin Qiao;  Yue-Shan Li;  Rui Zeng;  Feng-Liang Liu;  Rong-Hua Luo;  Chong Huang;  Yi-Fei Wang;  Jie Zhang;  Baoxue Quan;  Chenjian Shen;  Xin Mao;  Xinlei Liu;  Weining Sun;  Wei Yang;  Xincheng Ni;  Kai Wang;  Ling Xu;  Zi-Lei Duan;  Qing-Cui Zou;  Hai-Lin Zhang;  Wang Qu;  Yang-Hao-Peng Long;  Ming-Hua Li;  Rui-Cheng Yang;  Xiaolong Liu;  Jing You;  Yangli Zhou;  Rui Yao;  Wen-Pei Li;  Jing-Ming Liu;  Pei Chen;  Yang Liu;  Gui-Feng Lin;  Xin Yang;  Jun Zou;  Linli Li;  Yiguo Hu;  Guang-Wen Lu;  Wei-Min Li;  Yu-Quan Wei;  Yong-Tang Zheng;  Jian Lei;  Shengyong Yang
收藏  |  浏览/下载：19/0  |  提交时间：2021/04/06
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Mineral Abundances Inferred From In Situ Reflectance Measurements of Chang'E-4 Landing Site in South Pole-Aitken Basin 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (16) : 9439-9447
作者:  Hu, Xiaoyi;  Ma, Pei;  Yang, Yazhou;  Zhu, Meng-Hua;  Jiang, Te;  Lucey, Paul G.;  Sun, Lingzhi;  Zhang, Hao;  Li, Chunlai;  Xu, Rui;  He, Zhiping;  Lin, Hongyu;  Huang, Changning;  Sun, Yuxue
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Yang, Jin-Yu;  Deng, Xiang-Yu;  Li, Yi-Sheng;  Ma, Xian-Cai;  Feng, Jian-Xiong;  Yu, Bing;  Chen, Yang;  Luo, Yi-Ling;  Wang, Xi;  Chen, Mei-Ling;  Fang, Zhi-Xin;  Zheng, Fu-Xiang;  Li, Yi-Ping;  Zhong, Qian;  Kang, Tie-Bang;  Song, Li-Bing;  Xu, Rui-Hua;  Zeng, Mu-Sheng;  Chen, Wei;  Zhang, Hui;  Xie, Wei;  Gao, Song
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27