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Peta–electron volt gamma-ray emission from the Crab Nebula 期刊论文
Science, 2021
作者:  The LHAASO Collaboration*†;  Zhen Cao;  F. Aharonian;  Q. An;  Axikegu;  L. X. Bai;  Y. X. Bai;  Y. W. Bao;  D. Bastieri;  X. J. Bi;  Y. J. Bi;  H. Cai;  J. T. Cai;  Zhe Cao;  J. Chang;  J. F. Chang;  B. M. Chen;  E. S. Chen;  J. Chen;  Liang Chen;  Liang Chen;  Long Chen;  M. J. Chen;  M. L. Chen;  Q. H. Chen;  S. H. Chen;  S. Z. Chen;  T. L. Chen;  X. L. Chen;  Y. Chen;  N. Cheng;  Y. D. Cheng;  S. W. Cui;  X. H. Cui;  Y. D. Cui;  B. D’Ettorre Piazzoli;  B. Z. Dai;  H. L. Dai;  Z. G. Dai;  Danzengluobu;  D. della Volpe;  X. J. Dong;  K. K. Duan;  J. H. Fan;  Y. Z. Fan;  Z. X. Fan;  J. Fang;  K. Fang;  C. F. Feng;  L. Feng;  S. H. Feng;  Y. L. Feng;  B. Gao;  C. D. Gao;  L. Q. Gao;  Q. Gao;  W. Gao;  M. M. Ge;  L. S. Geng;  G. H. Gong;  Q. B. Gou;  M. H. Gu;  F. L. Guo;  J. G. Guo;  X. L. Guo;  Y. Q. Guo;  Y. Y. Guo;  Y. A. Han;  H. H. He;  H. N. He;  J. C. He;  S. L. He;  X. B. He;  Y. He;  M. Heller;  Y. K. Hor;  C. Hou;  X. Hou;  H. B. Hu;  S. Hu;  S. C. Hu;  X. J. Hu;  D. H. Huang;  Q. L. Huang;  W. H. Huang;  X. T. Huang;  X. Y. Huang;  Z. C. Huang;  F. Ji;  X. L. Ji;  H. Y. Jia;  K. Jiang;  Z. J. Jiang;  C. Jin;  T. Ke;  D. Kuleshov;  K. Levochkin;  B. B. Li;  Cheng Li;  Cong Li;  F. Li;  H. B. Li;  H. C. Li;  H. Y. Li;  Jian Li;  Jie Li;  K. Li;  W. L. Li;  X. R. Li;  Xin Li;  Xin Li;  Y. Li;  Y. Z. Li;  Zhe Li;  Zhuo Li;  E. W. Liang;  Y. F. Liang;  S. J. Lin;  B. Liu;  C. Liu;  D. Liu;  H. Liu;  H. D. Liu;  J. Liu;  J. L. Liu;  J. S. Liu;  J. Y. Liu;  M. Y. Liu;  R. Y. Liu;  S. M. Liu;  W. Liu;  Y. Liu;  Y. N. Liu;  Z. X. Liu;  W. J. Long;  R. Lu;  H. K. Lv;  B. Q. Ma;  L. L. Ma;  X. H. Ma;  J. R. Mao;  A. Masood;  Z. Min;  W. Mitthumsiri;  T. Montaruli;  Y. C. Nan;  B. Y. Pang;  P. Pattarakijwanich;  Z. Y. Pei;  M. Y. Qi;  Y. Q. Qi;  B. Q. Qiao;  J. J. Qin;  D. Ruffolo;  V. Rulev;  A. Saiz;  L. Shao;  O. Shchegolev;  X. D. Sheng;  J. Y. Shi;  H. C. Song;  Yu. V. Stenkin;  V. Stepanov;  Y. Su;  Q. N. Sun;  X. N. Sun;  Z. B. Sun;  P. H. T. Tam;  Z. B. Tang;  W. W. Tian;  B. D. Wang;  C. Wang;  H. Wang;  H. G. Wang;  J. C. Wang;  J. S. Wang;  L. P. Wang;  L. Y. Wang;  R. N. Wang;  Wei Wang;  Wei Wang;  X. G. Wang;  X. J. Wang;  X. Y. Wang;  Y. Wang;  Y. D. Wang;  Y. J. Wang;  Y. P. Wang;  Z. H. Wang;  Z. X. Wang;  Zhen Wang;  Zheng Wang;  D. M. Wei;  J. J. Wei;  Y. J. Wei;  T. Wen;  C. Y. Wu;  H. R. Wu;  S. Wu;  W. X. Wu;  X. F. Wu;  S. Q. Xi;  J. Xia;  J. J. Xia;  G. M. Xiang;  D. X. Xiao;  G. Xiao;  H. B. Xiao;  G. G. Xin;  Y. L. Xin;  Y. Xing;  D. L. Xu;  R. X. Xu;  L. Xue;  D. H. Yan;  J. Z. Yan;  C. W. Yang;  F. F. Yang;  J. Y. Yang;  L. L. Yang;  M. J. Yang;  R. Z. Yang;  S. B. Yang;  Y. H. Yao;  Z. G. Yao;  Y. M. Ye;  L. Q. Yin;  N. Yin;  X. H. You;  Z. Y. You;  Y. H. Yu;  Q. Yuan;  H. D. Zeng;  T. X. Zeng;  W. Zeng;  Z. K. Zeng;  M. Zha;  X. X. Zhai;  B. B. Zhang;  H. M. Zhang;  H. Y. Zhang;  J. L. Zhang;  J. W. Zhang;  L. X. Zhang;  Li Zhang;  Lu Zhang;  P. F. Zhang;  P. P. Zhang;  R. Zhang;  S. R. Zhang;  S. S. Zhang;  X. Zhang;  X. P. Zhang;  Y. F. Zhang;  Y. L. Zhang;  Yi Zhang;  Yong Zhang;  B. Zhao;  J. Zhao;  L. Zhao;  L. Z. Zhao;  S. P. Zhao;  F. Zheng;  Y. Zheng;  B. Zhou;  H. Zhou;  J. N. Zhou;  P. Zhou;  R. Zhou;  X. X. Zhou;  C. G. Zhu;  F. R. Zhu;  H. Zhu;  K. J. Zhu;  X. Zuo
收藏  |  浏览/下载：14/0  |  提交时间：2021/07/27
Evolution of vision and hearing modalities in theropod dinosaurs 期刊论文
Science, 2021
作者:  Jonah N. Choiniere;  James M. Neenan;  Lars Schmitz;  David P. Ford;  Kimberley E. J. Chapelle;  Amy M. Balanoff;  Justin S. Sipla;  Justin A. Georgi;  Stig A. Walsh;  Mark A. Norell;  Xing Xu;  James M. Clark;  Roger B. J. Benson
收藏  |  浏览/下载：16/0  |  提交时间：2021/05/14
Trace element catalyses mineral replacement reactions and facilitates ore formation 期刊论文
Nature Communications, 2021
作者:  Yanlu Xing;  Joë;  l Brugger;  Barbara Etschmann;  Andrew G. Tomkins;  Andrew J. Frierdich;  Xiya Fang
收藏  |  浏览/下载：7/0  |  提交时间：2021/03/12
The acidity of atmospheric particles and clouds 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (8) : 4809-4888
作者:  Pye, Havala O. T.;  Nenes, Athanasios;  Alexander, Becky;  Ault, Andrew P.;  Barth, Mary C.;  Clegg, Simon L.;  Collett, Jeffrey L., Jr.;  Fahey, Kathleen M.;  Hennigan, Christopher J.;  Herrmann, Hartmut;  Kanakidou, Maria;  Kelly, James T.;  Ku, I-Ting;  McNeill, V. Faye;  Riemer, Nicole;  Schaefer, Thomas;  Shi, Guoliang;  Tilgner, Andreas;  Walker, John T.;  Wang, Tao;  Weber, Rodney;  Xing, Jia;  Zaveri, Rahul A.;  Zuend, Andreas
收藏  |  浏览/下载：15/0  |  提交时间：2020/07/02
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Mid-21st century ozone air quality and health burden in China under emissions scenarios and climate change 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2019, 14 (7)
作者:  Westervelt, D. M.;  Ma, C. T.;  He, M. Z.;  Fiore, A. M.;  Kinney, P. L.;  Kioumourtzoglou, M-A;  Wang, S.;  Xing, J.;  Ding, D.;  Correa, G.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
ozone  climate change  China  health  model  
Ultrapotent chemogenetics for research and potential clinical applications 期刊论文
SCIENCE, 2019, 364 (6436) : 146-+
作者:  Magnus, Christopher J.;  Lee, Peter H.;  Bonaventura, Jordi;  Zemla, Roland;  Gomez, Juan L.;  Ramirez, Melissa H.;  Hu, Xing;  Galvan, Adriana;  Basu, Jayeeta;  Michaelides, Michael;  Sternson, Scott M.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Long-term trends in the ambient PM2.5- and O-3-related mortality burdens in the United States under emission reductions from 1990 to 2010 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (20) : 15003-15016
作者:  Zhang, Yugiang;  West, J. Jason;  Mathur, Rohit;  Xing, Jia;  Hogrefe, Christian;  Roselle, Shawn J.;  Bash, Jesse O.;  Pleim, Jonathan E.;  Gan, Chuen-Meei;  Wong, David C.
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
RAP2 mediates mechanoresponses of the Hippo pathway 期刊论文
NATURE, 2018, 560 (7720) : 655-+
作者:  Meng, Zhipeng;  Qiu, Yunjiang;  Lin, Kimberly C.;  Kumar, Aditya;  Placone, Jesse K.;  Fang, Cao;  Wang, Kuei-Chun;  Lu, Shicong;  Pan, Margaret;  Hong, Audrey W.;  Moroishi, Toshiro;  Luo, Min;  Plouffe, Steven W.;  Diao, Yarui;  Ye, Zhen;  Park, Hyun Woo;  Wang, Xiaoqiong;  Yu, Fa-Xing;  Chien, Shu;  Wang, Cun-Yu;  Ren, Bing;  Engler, Adam J.;  Guan, Kun-Liang
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 期刊论文
NATURE COMMUNICATIONS, 2018, 9
作者:  Zhang, Cun-Jin;  Wang, Chenhui;  Jiang, Meiling;  Gu, Chunfang;  Xiao, Jianxin;  Chen, Xing;  Martin, Bradley N.;  Tang, Fangqiang;  Yamamoto, Erin;  Xian, Yibo;  Wang, Han;  Li, Fengling;  Sartor, R. Balfour;  Smith, Howard;  Husni, M. Elaine;  Shi, Fu-Dong;  Gao, Ji;  Carman, Julie;  Dongre, Ashok;  McKarns, Susan C.;  Coppieters, Ken;  Jorgensen, Trine N.;  Leonard, Warren J.;  Li, Xiaoxia
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27