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Different physicochemical behaviors of nitrate and ammonium during transport: a case study on Mt. Hua, China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Can Wu, Cong Cao, Jianjun Li, Shaojun Lv, Jin Li, Xiaodi Liu, Si Zhang, Shijie Liu, Fan Zhang, Jingjing Meng, and Gehui Wang
收藏  |  浏览/下载:8/0  |  提交时间:2022/06/24
Vegetation feedback causes delayed ecosystem response to East Asian Summer Monsoon Rainfall during the Holocene 期刊论文
Nature Communications, 2021
作者:  Jun Cheng;  Haibin Wu;  Zhengyu Liu;  Peng Gu;  Jingjing Wang;  Cheng Zhao;  Qin Li;  Haishan Chen;  Huayu Lu;  Haibo Hu;  Yu Gao;  Miao Yu;  Yaoming Song
收藏  |  浏览/下载:12/0  |  提交时间:2021/04/06
A developmental landscape of 3D-cultured human pre-gastrulation embryos 期刊论文
NATURE, 2020, 577 (7791) : 537-+
作者:  Xiang, Lifeng;  Yin, Yu;  Zheng, Yun;  Ma, Yanping;  Li, Yonggang;  Zhao, Zhigang;  Guo, Junqiang;  Ai, Zongyong;  Niu, Yuyu;  Duan, Kui;  He, Jingjing;  Ren, Shuchao;  Wu, Dan;  Bai, Yun;  Shang, Zhouchun;  Dai, Xi;  Ji, Weizhi;  Li, Tianqing
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Our understanding of how human embryos develop before gastrulation, including spatial self-organization and cell type ontogeny, remains limited by available two-dimensional technological platforms(1,2) that do not recapitulate the in vivo conditions(3-5). Here we report a three-dimensional (3D) blastocyst-culture system that enables human blastocyst development up to the primitive streak anlage stage. These 3D embryos mimic developmental landmarks and 3D architectures in vivo, including the embryonic disc, amnion, basement membrane, primary and primate unique secondary yolk sac, formation of anterior-posterior polarity and primitive streak anlage. Using single-cell transcriptome profiling, we delineate ontology and regulatory networks that underlie the segregation of epiblast, primitive endoderm and trophoblast. Compared with epiblasts, the amniotic epithelium shows unique and characteristic phenotypes. After implantation, specific pathways and transcription factors trigger the differentiation of cytotrophoblasts, extravillous cytotrophoblasts and syncytiotrophoblasts. Epiblasts undergo a transition to pluripotency upon implantation, and the transcriptome of these cells is maintained until the generation of the primitive streak anlage. These developmental processes are driven by different pluripotency factors. Together, findings from our 3D-culture approach help to determine the molecular and morphogenetic developmental landscape that occurs during human embryogenesis.


A 3D culture system to model human embryonic development, together with single-cell transcriptome profiling, provides insights into the molecular developmental landscape during human post-implantation embryogenesis.


  
Profiles of MBL Cloud and Drizzle Microphysical Properties Retrieved From Ground-Based Observations and Validated by Aircraft In Situ Measurements Over the Azores 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (9)
作者:  Wu, Peng;  Dong, Xiquan;  Xi, Baike;  Tian, Jingjing;  Ward, Dale M.
收藏  |  浏览/下载:11/0  |  提交时间:2020/07/02
aircraft measurements  cloud and precipitation  ground-based observations  microphysics retrieval  
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:43/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Targeting of temperate phages drives loss of type I CRISPR-Cas systems 期刊论文
NATURE, 2020, 578 (7793) : 149-+
作者:  Xiang, Lifeng;  Yin, Yu;  Zheng, Yun;  Ma, Yanping;  Li, Yonggang;  Zhao, Zhigang;  Guo, Junqiang;  Ai, Zongyong;  Niu, Yuyu;  Duan, Kui;  He, Jingjing;  Ren, Shuchao;  Wu, Dan;  Bai, Yun;  Shang, Zhouchun;  Dai, Xi;  Ji, Weizhi;  Li, Tianqing
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

On infection of their host, temperate viruses that infect bacteria (bacteriophages  hereafter referred to as phages) enter either a lytic or a lysogenic cycle. The former results in lysis of bacterial cells and phage release (resulting in horizontal transmission), whereas lysogeny is characterized by the integration of the phage into the host genome, and dormancy (resulting in vertical transmission)(1). Previous co-culture experiments using bacteria and mutants of temperate phages that are locked in the lytic cycle have shown that CRISPR-Cas systems can efficiently eliminate the invading phages(2,3). Here we show that, when challenged with wild-type temperate phages (which can become lysogenic), type I CRISPR-Cas immune systems cannot eliminate the phages from the bacterial population. Furthermore, our data suggest that, in this context, CRISPR-Cas immune systems are maladaptive to the host, owing to the severe immunopathological effects that are brought about by imperfect matching of spacers to the integrated phage sequences (prophages). These fitness costs drive the loss of CRISPR-Cas from bacterial populations, unless the phage carries anti-CRISPR (acr) genes that suppress the immune system of the host. Using bioinformatics, we show that this imperfect targeting is likely to occur frequently in nature. These findings help to explain the patchy distribution of CRISPR-Cas immune systems within and between bacterial species, and highlight the strong selective benefits of phage-encoded acr genes for both the phage and the host under these circumstances.


CRISPR-Cas systems cannot eliminate temperate bacteriophages from bacterial populations and-in this context-the systems impose immunopathological costs on the host, creating selective pressures that may explain their patchy distribution in bacteria.


  
Coastal Alaska forests under climate change: What to expect? 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 448: 432-444
作者:  Ma, Wu;  Zhou, Xiaoping;  Liang, Jingjing;  Zhou, Mo
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Matrix growth model  Climate change  Forest dynamics  Disturbances  Temperate rainforest  
Characteristics and sources of halogenated hydrocarbons in the Yellow River Delta region, northern China 期刊论文
ATMOSPHERIC RESEARCH, 2019, 225: 70-80
作者:  Zheng, Penggang;  Chen, Tianshu;  Dong, Can;  Liu, Yuhong;  Li, Hongyong;  Han, Guangxuan;  Sun, Jingjing;  Wu, Lin;  Gao, Xiaomei;  Wang, Xinfeng;  Qi, Yanbin;  Zhang, Qingzhu;  Wang, Wenxing;  Xue, Likun
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Halocarbons  Yellow River Delta  Oil field  Positive matrix factorization  Montreal Protocol  
Molecular distribution and stable carbon isotopic compositions of dicarboxylic acids and related SOA from biogenic sources in the summertime atmosphere of Mt. Tai in the North China Plain 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (20) : 15069-15086
作者:  Meng, Jingjing;  Wang, Gehui;  Hou, Zhanfang;  Liu, Xiaodi;  Wei, Benjie;  Wu, Can;  Cao, Cong;  Wang, Jiayuan;  Li, Jianjun;  Cao, Junji;  Zhang, Erxun;  Dong, Jie;  Liu, Jiazhen;  Ge, Shuangshuang;  Xie, Yuning
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Synergy of synthesis, computation and NMR reveals correct baulamycin structures 期刊论文
NATURE, 2017, 547 (7664) : 436-440
作者:  Wu, Jingjing;  Lorenzo, Paula;  Zhong, Siying;  Ali, Muhammad;  Butts, Craig P.;  Myers, Eddie L.;  Aggarwal, Varinder K.
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27