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Petrogenesis of the Cretaceous granitoids in Zhejiang, northeast South China Block and their implications for episodic retreat and roll-back of the Paleo-Pacific Plate 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1514-1536
作者:  Tao, Lu;  Pan, Fa-Bin;  Liu, Rong;  Jin, Chong;  Jia, Bao-Jian;  He, Xiaobo
收藏  |  浏览/下载:10/0  |  提交时间:2020/08/18
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Elucidating cloud vertical structures based on three-year Ka-band cloud radar observations from Beijing, China 期刊论文
ATMOSPHERIC RESEARCH, 2019, 222: 88-99
作者:  Zhang, Yong;  Zhou, Qing;  Lv, Shanshan;  Jia, Shuze;  Tao, Fa;  Chen, Dandan;  Guo, Jianping
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/26
Beijing  Climatology  Cloud base height  Cloud top height  Ka-band millimeter-wave cloud radar  Vertical structures  
Unconventional CN vacancies suppress iron-leaching in Prussian blue analogue pre-catalyst for boosted oxygen evolution catalysis 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Yu, Zi-You;  Duan, Yu;  Liu, Jian-Dang;  Chen, Yu;  Liu, Xiao-Kang;  Liu, Wei;  Ma, Tao;  Li, Yi;  Zheng, Xu-Sheng;  Yao, Tao;  Gao, Min-Rui;  Zhu, Jun-Fa;  Ye, Bang-Jiao;  Yu, Shu-Hong
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
安徽湛岭铼钼矿床中分散元素铼的成矿作用研究 项目
项目编号:41872081; 经费:660000(CNY); 起止日期:2019 / dc_date_end
项目负责人:  周涛发
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
East Asian dust storm in May 2017: observations, modelling, and its influence on the Asia-Pacific region 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (11) : 8353-8371
作者:  Zhang, Xiao-Xiao;  Sharratt, Brenton;  Liu, Lian-You;  Wang, Zi-Fa;  Pan, Xiao-Le;  Lei, Jia-Qiang;  Wu, Shi-Xin;  Huang, Shuang-Yan;  Guo, Yu-Hong;  Li, Jie;  Tang, Xiao;  Yang, Ting;  Tian, Yu;  Chen, Xue-Shun;  Hao, Jian-Qi;  Zheng, Hai-Tao;  Yang, Yan-Yan;  Lyu, Yan-Li
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
Improved retrieval of cloud base heights from ceilometer using a non-standard instrument method 期刊论文
ATMOSPHERIC RESEARCH, 2018, 202: 148-155
作者:  Wang, Yang;  Zhao, Chuanfeng;  Dong, Zipeng;  Li, Zhanqing;  Hu, Shuzhen;  Chen, Tianmeng;  Tao, Fa;  Wang, Yuzhao
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Cloud base height  Ceilometer  Micro-pulse lidar  Value distribution equalization  
Comparison of cloud top heights derived from FY-2 meteorological satellites with heights derived from ground-based millimeter wavelength cloud radar 期刊论文
ATMOSPHERIC RESEARCH, 2018, 199: 113-127
作者:  Wang, Zhe;  Wang, Zhenhui;  Cao, Xiaozhong;  Tao, Fa
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
FY-2 satellites  Cloud radar  Cloud detection  Cloud top height