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Quantum walks on a programmable two-dimensional 62-qubit superconducting processor 期刊论文
Science, 2021
作者:  Ming Gong;  Shiyu Wang;  Chen Zha;  Ming-Cheng Chen;  He-Liang Huang;  Yulin Wu;  Qingling Zhu;  Youwei Zhao;  Shaowei Li;  Shaojun Guo;  Haoran Qian;  Yangsen Ye;  Fusheng Chen;  Chong Ying;  Jiale Yu;  Daojin Fan;  Dachao Wu;  Hong Su;  Hui Deng;  Hao Rong;  Kaili Zhang;  Sirui Cao;  Jin Lin;  Yu Xu;  Lihua Sun;  Cheng Guo;  Na Li;  Futian Liang;  V. M. Bastidas;  Kae Nemoto;  W. J. Munro;  Yong-Heng Huo;  Chao-Yang Lu;  Cheng-Zhi Peng;  Xiaobo Zhu;  Jian-Wei Pan
收藏  |  浏览/下载:16/0  |  提交时间:2021/06/07
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease 期刊论文
Science, 2020
作者:  Wenhao Dai;  Bing Zhang;  Xia-Ming Jiang;  Haixia Su;  Jian Li;  Yao Zhao;  Xiong Xie;  Zhenming Jin;  Jingjing Peng;  Fengjiang Liu;  Chunpu Li;  You Li;  Fang Bai;  Haofeng Wang;  Xi Cheng;  Xiaobo Cen;  Shulei Hu;  Xiuna Yang;  Jiang Wang;  Xiang Liu;  Gengfu Xiao;  Hualiang Jiang;  Zihe Rao;  Lei-Ke Zhang;  Yechun Xu;  Haitao Yang;  Hong Liu
收藏  |  浏览/下载:18/0  |  提交时间:2020/06/22
Chesapeake Bay acidification buffered by spatially decoupled carbonate mineral cycling 期刊论文
NATURE GEOSCIENCE, 2020, 13 (6) : 441-+
作者:  Su, Jianzhong;  Cai, Wei-Jun;  Brodeur, Jean;  Chen, Baoshan;  Hussain, Najid;  Yao, Yichen;  Ni, Chaoying;  Testa, Jeremy M.;  Li, Ming;  Xie, Xiaohui;  Ni, Wenfei;  Scaboo, K. Michael;  Xu, Yuan-yuan;  Cornwell, Jeffrey;  Gurbisz, Cassie;  Owens, Michael S.;  Waldbusser, George G.;  Dai, Minhan;  Kemp, W. Michael
收藏  |  浏览/下载:9/0  |  提交时间:2020/06/09
Influx of African biomass burning aerosol during the Amazonian dry season through layered transatlantic transport of black carbon-rich smoke 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (8) : 4757-4785
作者:  Holanda, Bruna A.;  Poehlker, Mira L.;  Walter, David;  Saturno, Jorge;  Soergel, Matthias;  Ditas, Jeannine;  Ditas, Florian;  Schulz, Christiane;  Franco, Marco Aurelio;  Wang, Qiaoqiao;  Donth, Tobias;  Artaxo, Paulo;  Barbosa, Henrique M. J.;  Borrmann, Stephan;  Braga, Ramon;  Brito, Joel;  Cheng, Yafang;  Dollner, Maximilian;  Kaiser, Johannes W.;  Klimach, Thomas;  Knote, Christoph;  Krueger, Ovid O.;  Fuetterer, Daniel;  Lavric, Jost, V;  Ma, Nan;  Machado, Luiz A. T.;  Ming, Jing;  Morais, Fernando G.;  Paulsen, Hauke;  Sauer, Daniel;  Schlager, Hans;  Schneider, Johannes;  Su, Hang;  Weinzierl, Bernadett;  Walser, Adrian;  Wendisch, Manfred;  Ziereis, Helmut;  Zoeger, Martin;  Poeschl, Ulrich;  Andreae, Meinrat O.;  Poehlker, Christopher
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/02
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Persistent, bioaccumulative, and toxic properties of liquid crystal monomers and their detection in indoor residential dust 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (52) : 26450-26458
作者:  Huijun Su;  Shaobo Shi;  Ming Zhu;  Doug Crump;  Robert J. Letcher;  John P. Giesy;  Guanyong Su
收藏  |  浏览/下载:12/0  |  提交时间:2020/02/18
liquid crystal displays (LCDs)  liquid crystal monomers (LCMs)  persistence (P)  bioaccumulation (B)  toxic (T)  
Discovery of topological Weyl fermion lines and drumhead surface states in a room temperature magnet 期刊论文
SCIENCE, 2019, 365 (6459) : 1278-+
作者:  Belopolski, Ilya;  Manna, Kaustuv;  Sanchez, Daniel S.;  Chang, Guoqing;  Ernst, Benedikt;  Yin, Jiaxin;  Zhang, Songtian S.;  Cochran, Tyler;  Shumiya, Nana;  Zheng, Hao;  Singh, Bahadur;  Bian, Guang;  Multer, Daniel;  Litskevich, Maksim;  Zhou, Xiaoting;  Huang, Shin-Ming;  Wang, Baokai;  Chang, Tay-Rong;  Xu, Su-Yang;  Bansil, Arun;  Felser, Claudia;  Lin, Hsin;  Hasan, M. Zahid
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Han, Tao;  Jiang, Shulong;  Zheng, Hong;  Yin, Qing;  Xie, Mengyu;  Little, Margaret R.;  Yin, Xiu;  Chen, Ming;  Song, Su Jung;  Beg, Amer A.;  Pandolfi, Pier Paolo;  Wan, Lixin
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Object-based precipitation system bias in grey zone simulation: the 2016 South China Sea summer monsoon onset 期刊论文
CLIMATE DYNAMICS, 2019, 53: 617-630
作者:  Su, Chun-Yian;  Wu, Chien-Ming;  Chen, Wei-Ting;  Chen, Jen-Her
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Object-based precipitation system  Precipitation bias  Grey zone simulation  Degree of convection organization  South China Sea summer monsoon onset