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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model 期刊论文
Science, 2021
作者:  Jingxin Qiao;  Yue-Shan Li;  Rui Zeng;  Feng-Liang Liu;  Rong-Hua Luo;  Chong Huang;  Yi-Fei Wang;  Jie Zhang;  Baoxue Quan;  Chenjian Shen;  Xin Mao;  Xinlei Liu;  Weining Sun;  Wei Yang;  Xincheng Ni;  Kai Wang;  Ling Xu;  Zi-Lei Duan;  Qing-Cui Zou;  Hai-Lin Zhang;  Wang Qu;  Yang-Hao-Peng Long;  Ming-Hua Li;  Rui-Cheng Yang;  Xiaolong Liu;  Jing You;  Yangli Zhou;  Rui Yao;  Wen-Pei Li;  Jing-Ming Liu;  Pei Chen;  Yang Liu;  Gui-Feng Lin;  Xin Yang;  Jun Zou;  Linli Li;  Yiguo Hu;  Guang-Wen Lu;  Wei-Min Li;  Yu-Quan Wei;  Yong-Tang Zheng;  Jian Lei;  Shengyong Yang
收藏  |  浏览/下载：14/0  |  提交时间：2021/04/06
Recycling and metabolic flexibility dictate life in the lower oceanic crust 期刊论文
NATURE, 2020, 579 (7798) : 250-+
作者:  Zhou, Peng;  Yang, Xing-Lou;  Wang, Xian-Guang;  Hu, Ben;  Zhang, Lei;  Zhang, Wei;  Si, Hao-Rui;  Zhu, Yan;  Li, Bei;  Huang, Chao-Lin;  Chen, Hui-Dong;  Chen, Jing;  Luo, Yun;  Guo, Hua;  Jiang, Ren-Di;  Liu, Mei-Qin;  Chen, Ying;  Shen, Xu-Rui;  Wang, Xi;  Zheng, Xiao-Shuang;  Zhao, Kai;  Chen, Quan-Jiao;  Deng, Fei;  Liu, Lin-Lin;  Yan, Bing;  Zhan, Fa-Xian;  Wang, Yan-Yi;  Xiao, Geng-Fu;  Shi, Zheng-Li
收藏  |  浏览/下载：37/0  |  提交时间：2020/05/13

The lithified lower oceanic crust is one of Earth'  s last biological frontiers as it is difficult to access. It is challenging for microbiota that live in marine subsurface sediments or igneous basement to obtain sufficient carbon resources and energy to support growth(1-3) or to meet basal power requirements(4) during periods of resource scarcity. Here we show how limited and unpredictable sources of carbon and energy dictate survival strategies used by low-biomass microbial communities that live 10-750 m below the seafloor at Atlantis Bank, Indian Ocean, where Earth'  s lower crust is exposed at the seafloor. Assays of enzyme activities, lipid biomarkers, marker genes and microscopy indicate heterogeneously distributed and viable biomass with ultralow cell densities (fewer than 2,000 cells per cm(3)). Expression of genes involved in unexpected heterotrophic processes includes those with a role in the degradation of polyaromatic hydrocarbons, use of polyhydroxyalkanoates as carbon-storage molecules and recycling of amino acids to produce compounds that can participate in redox reactions and energy production. Our study provides insights into how microorganisms in the plutonic crust are able to survive within fractures or porous substrates by coupling sources of energy to organic and inorganic carbon resources that are probably delivered through the circulation of subseafloor fluids or seawater.


  
Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes 期刊论文
SCIENCE, 2018, 359 (6380) : 1151-+
作者:  Zhao, Liping;  Zhang, Feng;  Ding, Xiaoying;  Wu, Guojun;  Lam, Yan Y.;  Wang, Xuejiao;  Fu, Huaqing;  Xue, Xinhe;  Lu, Chunhua;  Ma, Jilin;  Yu, Lihua;  Xu, Chengmei;  Ren, Zhongying;  Xu, Ying;  Xu, Songmei;  Shen, Hongli;  Zhu, Xiuli;  Shi, Yu;  Shen, Qingyun;  Dong, Weiping;  Liu, Rui;  Ling, Yunxia;  Zeng, Yue;  Wang, Xingpeng;  Zhang, Qianpeng;  Wang, Jing;  Wang, Linghua;  Wu, Yanqiu;  Zeng, Benhua;  Wei, Hong;  Zhang, Menghui;  Peng, Yongde;  Zhang, Chenhong
收藏  |  浏览/下载：26/0  |  提交时间：2019/11/27
Curbing Air Pollution and Greenhouse Gas Emissions from Industrial Boilers in China 科技报告
来源：US Department of Energy (DOE). 出版年： 2015
作者:  Shen, Bo;  Price, Lynn K;  Lu, Hongyou;  Liu, Xu;  Tsen, Katherine;  Xiangyang, Wei;  Yunpeng, Zhang;  Jian, Guan;  Rui, Hou;  Junfeng, Zhang;  Yuqun, Zhuo;  Shumao, Xia;  Yafeng, Han;  Manzhi, Liu
收藏  |  浏览/下载：9/0  |  提交时间：2019/04/05