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Chinese regulations are working - why is surface ozone over industrialized areas still high? Applying lessons from Northeast US air quality evolution 期刊论文
Geophysical Research Letters, 2021
作者:  Xiaokang Chen;  Zhe Jiang;  Yanan Shen;  Rui Li;  Yunfei Fu;  Jane Liu;  Han Han;  Hong Liao;  Xugeng Cheng;  Dylan B. A. Jones;  Helen Worden;  Gonzalo Gonzá;  lez Abad
收藏  |  浏览/下载：14/0  |  提交时间：2021/07/27
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 期刊论文
Science, 2020
作者:  Qian Zhang;  Paul Bastard;  Zhiyong Liu;  Jérémie Le Pen;  Marcela Moncada-Velez;  Jie Chen;  Masato Ogishi;  Ira K. D. Sabli;  Stephanie Hodeib;  Cecilia Korol;  Jérémie Rosain;  Kaya Bilguvar;  Junqiang Ye;  Alexandre Bolze;  Benedetta Bigio;  Rui Yang;  Andrés Augusto Arias;  Qinhua Zhou;  Yu Zhang;  Fanny Onodi;  Sarantis Korniotis;  Léa Karpf;  Quentin Philippot;  Marwa Chbihi;  Lucie Bonnet-Madin;  Karim Dorgham;  Nikaïa Smith;  William M. Schneider;  Brandon S. Razooky;  Hans-Heinrich Hoffmann;  Eleftherios Michailidis;  Leen Moens;  Ji Eun Han;  Lazaro Lorenzo;  Lucy Bizien;  Philip Meade;  Anna-Lena Neehus;  Aileen Camille Ugurbil;  Aurélien Corneau;  Gaspard Kerner;  Peng Zhang;  Franck Rapaport;  Yoann Seeleuthner;  Jeremy Manry;  Cecile Masson;  Yohann Schmitt;  Agatha Schlüter;  Tom Le Voyer;  Taushif Khan;  Juan Li;  Jacques Fellay;  Lucie Roussel;  Mohammad Shahrooei;  Mohammed F. Alosaimi;  Davood Mansouri;  Haya Al-Saud;  Fahd Al-Mulla;  Feras Almourfi;  Saleh Zaid Al-Muhsen;  Fahad Alsohime;  Saeed Al Turki;  Rana Hasanato;  Diederik van de Beek;  Andrea Biondi;  Laura Rachele Bettini;  Mariella D’Angio’;  Paolo Bonfanti;  Luisa Imberti;  Alessandra Sottini;  Simone Paghera;  Eugenia Quiros-Roldan;  Camillo Rossi;  Andrew J. Oler;  Miranda F. Tompkins;  Camille Alba;  Isabelle Vandernoot;  Jean-Christophe Goffard;  Guillaume Smits;  Isabelle Migeotte;  Filomeen Haerynck;  Pere Soler-Palacin;  Andrea Martin-Nalda;  Roger Colobran;  Pierre-Emmanuel Morange;  Sevgi Keles;  Fatma Çölkesen;  Tayfun Ozcelik;  Kadriye Kart Yasar;  Sevtap Senoglu;  Şemsi Nur Karabela;  Carlos Rodríguez-Gallego;  Giuseppe Novelli;  Sami Hraiech;  Yacine Tandjaoui-Lambiotte;  Xavier Duval;  Cédric Laouénan;  COVID-STORM Clinicians†;  COVID Clinicians†;  Imagine COVID Group†;  French COVID Cohort Study Group†;  CoV-Contact Cohort†;  Amsterdam UMC Covid-19 Biobank†;  COVID Human Genetic Effort†;  NIAID-USUHS/TAGC COVID Immunity Group†;  Andrew L. Snow;  Clifton L. Dalgard;  Joshua D. Milner;  Donald C. Vinh;  Trine H. Mogensen;  Nico Marr;  András N. Spaan;  Bertrand Boisson;  Stéphanie Boisson-Dupuis;  Jacinta Bustamante;  Anne Puel;  Michael J. Ciancanelli;  Isabelle Meyts;  Tom Maniatis;  Vassili Soumelis;  Ali Amara;  Michel Nussenzweig;  Adolfo García-Sastre;  Florian Krammer;  Aurora Pujol;  Darragh Duffy;  Richard P. Lifton;  Shen-Ying Zhang;  Guy Gorochov;  Vivien Béziat;  Emmanuelle Jouanguy;  Vanessa Sancho-Shimizu;  Charles M. Rice;  Laurent Abel;  Luigi D. Notarangelo;  Aurélie Cobat;  Helen C. Su;  Jean-Laurent Casanova
收藏  |  浏览/下载：21/0  |  提交时间：2020/10/26
Autoantibodies against type I IFNs in patients with life-threatening COVID-19 期刊论文
Science, 2020
作者:  Paul Bastard;  Lindsey B. Rosen;  Qian Zhang;  Eleftherios Michailidis;  Hans-Heinrich Hoffmann;  Yu Zhang;  Karim Dorgham;  Quentin Philippot;  Jérémie Rosain;  Vivien Béziat;  Jérémy Manry;  Elana Shaw;  Liis Haljasmägi;  Pärt Peterson;  Lazaro Lorenzo;  Lucy Bizien;  Sophie Trouillet-Assant;  Kerry Dobbs;  Adriana Almeida de Jesus;  Alexandre Belot;  Anne Kallaste;  Emilie Catherinot;  Yacine Tandjaoui-Lambiotte;  Jeremie Le Pen;  Gaspard Kerner;  Benedetta Bigio;  Yoann Seeleuthner;  Rui Yang;  Alexandre Bolze;  András N. Spaan;  Ottavia M. Delmonte;  Michael S. Abers;  Alessandro Aiuti;  Giorgio Casari;  Vito Lampasona;  Lorenzo Piemonti;  Fabio Ciceri;  Kaya Bilguvar;  Richard P. Lifton;  Marc Vasse;  David M. Smadja;  Mélanie Migaud;  Jérome Hadjadj;  Benjamin Terrier;  Darragh Duffy;  Lluis Quintana-Murci;  Diederik van de Beek;  Lucie Roussel;  Donald C. Vinh;  Stuart G. Tangye;  Filomeen Haerynck;  David Dalmau;  Javier Martinez-Picado;  Petter Brodin;  Michel C. Nussenzweig;  Stéphanie Boisson-Dupuis;  Carlos Rodríguez-Gallego;  Guillaume Vogt;  Trine H. Mogensen;  Andrew J. Oler;  Jingwen Gu;  Peter D. Burbelo;  Jeffrey I. Cohen;  Andrea Biondi;  Laura Rachele Bettini;  Mariella D'Angio;  Paolo Bonfanti;  Patrick Rossignol;  Julien Mayaux;  Frédéric Rieux-Laucat;  Eystein S. Husebye;  Francesca Fusco;  Matilde Valeria Ursini;  Luisa Imberti;  Alessandra Sottini;  Simone Paghera;  Eugenia Quiros-Roldan;  Camillo Rossi;  Riccardo Castagnoli;  Daniela Montagna;  Amelia Licari;  Gian Luigi Marseglia;  Xavier Duval;  Jade Ghosn;  HGID Lab§;  NIAID-USUHS Immune Response to COVID Group§;  COVID Clinicians§;  COVID-STORM Clinicians§;  Imagine COVID Group§;  French COVID Cohort Study Group§;  The Milieu Intérieur Consortium§;  CoV-Contact Cohort§;  Amsterdam UMC Covid-19 Biobank§;  COVID Human Genetic Effort§;  John S. Tsang;  Raphaela Goldbach-Mansky;  Kai Kisand;  Michail S. Lionakis;  Anne Puel;  Shen-Ying Zhang;  Steven M. Holland;  Guy Gorochov;  Emmanuelle Jouanguy;  Charles M. Rice;  Aurélie Cobat;  Luigi D. Notarangelo;  Laurent Abel;  Helen C. Su;  Jean-Laurent Casanova
收藏  |  浏览/下载：14/0  |  提交时间：2020/10/26
FACT caught in the act of manipulating the nucleosome 期刊论文
NATURE, 2020, 577 (7790) : 426-+
作者:  Shen, Helen
收藏  |  浏览/下载：4/0  |  提交时间：2020/07/03

The organization of genomic DNA into nucleosomes profoundly affects all DNA-related processes in eukaryotes. The histone chaperone known as '  facilitates chromatin transcription'  (FACT(1)) (consisting of subunits SPT16 and SSRP1) promotes both disassembly and reassembly of nucleosomes during gene transcription, DNA replication and DNA repair(2). However, the mechanism by which FACT causes these opposing outcomes is unknown. Here we report two cryo-electron-microscopic structures of human FACT in complex with partially assembled subnucleosomes, with supporting biochemical and hydrogen-deuterium exchange data. We find that FACT is engaged in extensive interactions with nucleosomal DNA and all histone variants. The large DNA-binding surface on FACT appears to be protected by the carboxy-terminal domains of both of its subunits, and this inhibition is released by interaction with H2A-H2B, allowing FACT-H2A-H2B to dock onto a complex containing DNA and histones H3 and H4 (ref. (3)). SPT16 binds nucleosomal DNA and tethers H2A-H2B through its carboxy-terminal domain by acting as a placeholder for DNA. SSRP1 also contributes to DNA binding, and can assume two conformations, depending on whether a second H2A-H2B dimer is present. Our data suggest a compelling mechanism for how FACT maintains chromatin integrity during polymerase passage, by facilitating removal of the H2A-H2B dimer, stabilizing intermediate subnucleosomal states and promoting nucleosome reassembly. Our findings reconcile discrepancies regarding the many roles of FACT and underscore the dynamic interactions between histone chaperones and nucleosomes.


  
The histone methyltransferase Setd2 is indispensable for V(D)J recombination 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Ji, Zhongzhong;  Sheng, Yaru;  Miao, Juju;  Li, Xiaoxia;  Zhao, Huifang;  Wang, Jinming;  Cheng, Chaping;  Wang, Xue;  Liu, Kaiyuan;  Zhang, Kai;  Xu, Longmei;  Yao, Jufang;  Shen, Lijing;  Hou, Jian;  Zhou, Wenhao;  Sun, Jinqiao;  Li, Li;  Gao, Wei-Qiang;  Zhu, Helen He
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
How domosquitoes smell us? The answers could help eradicate disease 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (9) : 2096-2098
作者:  Shen, Helen H.
收藏  |  浏览/下载：0/0  |  提交时间：2019/11/27