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The chain of chirality transfer in tellurium nanocrystals 期刊论文
Science, 2021
作者:  Assaf Ben-Moshe;  Alessandra da Silva;  Alexander Müller;  Anas Abu-Odeh;  Patrick Harrison;  Jacob Waelder;  Farnaz Niroui;  Colin Ophus;  Andrew M. Minor;  Mark Asta;  Wolfgang Theis;  Peter Ercius;  A. Paul Alivisatos
收藏  |  浏览/下载:21/0  |  提交时间:2021/05/21
Haplotype-resolved diverse human genomes and integrated analysis of structural variation 期刊论文
Science, 2021
作者:  Peter Ebert;  Peter A. Audano;  Qihui Zhu;  Bernardo Rodriguez-Martin;  David Porubsky;  Marc Jan Bonder;  Arvis Sulovari;  Jana Ebler;  Weichen Zhou;  Rebecca Serra Mari;  Feyza Yilmaz;  Xuefang Zhao;  PingHsun Hsieh;  Joyce Lee;  Sushant Kumar;  Jiadong Lin;  Tobias Rausch;  Yu Chen;  Jingwen Ren;  Martin Santamarina;  Wolfram Höps;  Hufsah Ashraf;  Nelson T. Chuang;  Xiaofei Yang;  Katherine M. Munson;  Alexandra P. Lewis;  Susan Fairley;  Luke J. Tallon;  Wayne E. Clarke;  Anna O. Basile;  Marta Byrska-Bishop;  André Corvelo;  Uday S. Evani;  Tsung-Yu Lu;  Mark J. P. Chaisson;  Junjie Chen;  Chong Li;  Harrison Brand;  Aaron M. Wenger;  Maryam Ghareghani;  William T. Harvey;  Benjamin Raeder;  Patrick Hasenfeld;  Allison A. Regier;  Haley J. Abel;  Ira M. Hall;  Paul Flicek;  Oliver Stegle;  Mark B. Gerstein;  Jose M. C. Tubio;  Zepeng Mu;  Yang I. Li;  Xinghua Shi;  Alex R. Hastie;  Kai Ye;  Zechen Chong;  Ashley D. Sanders;  Michael C. Zody;  Michael E. Talkowski;  Ryan E. Mills;  Scott E. Devine;  Charles Lee;  Jan O. Korbel;  Tobias Marschall;  Evan E. Eichler
收藏  |  浏览/下载:26/0  |  提交时间:2021/04/06
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:37/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Translating Marine Animal Tracking Data into Conservation Policy and Management 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2019, 34 (5) : 459-473
作者:  Hays, Graeme C.;  Bailey, Helen;  Bograd, Steven J.;  Bowen, W. Don;  Campagna, Claudio;  Carmichael, Ruth H.;  Casale, Paolo;  Chiaradia, Andre;  Costa, Daniel P.;  Cuevas, Eduardo;  de Bruyn, P. J. Nico;  Dias, Maria P.;  Duarte, Carlos M.;  Dunn, Daniel C.;  Dutton, Peter H.;  Esteban, Nicole;  Friedlaender, Ari;  Goetz, Kimberly T.;  Godley, Brendan J.;  Halpin, Patrick N.;  Hamann, Mark;  Hammerschlag, Neil;  Harcourt, Robert;  Harrison, Autumn-Lynn;  Hazen, Elliott L.;  Heupel, Michelle R.;  Hoyt, Erich;  Humphries, Nicolas E.;  Kot, Connie Y.;  Lea, James S. E.;  Marsh, Helene;  Maxwell, Sara M.;  McMahon, Clive R.;  di Sciara, Giuseppe Notarbartolo;  Palacios, Daniel M.;  Phillips, Richard A.;  Righton, David;  Schofield, Gail;  Seminoff, Jeffrey A.;  Simpfendorfer, Colin A.;  Sims, David W.;  Takahashi, Akinori;  Tetley, Michael J.;  Thums, Michele;  Trathan, Philip N.;  Villegas-Amtmann, Stella;  Wells, Randall S.;  Whiting, Scott D.;  Wildermann, Natalie E.;  Msequeira, Ana M. M.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/26
Underlying causes of Eurasian midcontinental aridity in simulations of mid-Holocene climate 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (17)
作者:  Bartlein, Patrick J.;  Harrison, Sandy P.;  Izumi, Kenji
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09