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Untangling local and remote influences in two major petrel habitats in the oligotrophic Southern Ocean 期刊论文
Global Change Biology, 2021
作者:  Daniel C. Jones;  Filipe R. Ceia;  Eugene Murphy;  Karine Delord;  Robert W. Furness;  Ariane Verdy;  Matthew Mazloff;  Richard A. Phillips;  Paul M. Sagar;  Jean-Baptiste Sallé;  e;  Ben Schreiber;  David R. Thompson;  Leigh G. Torres;  Philip J. Underwood;  Henri Weimerskirch;  José;  C. Xavier
收藏  |  浏览/下载:8/0  |  提交时间:2021/08/30
Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts 期刊论文
Science, 2021
作者:  Jeffrey J. Quinn;  Matthew G. Jones;  Ross A. Okimoto;  Shigeki Nanjo;  Michelle M. Chan;  Nir Yosef;  Trever G. Bivona;  Jonathan S. Weissman
收藏  |  浏览/下载:9/0  |  提交时间:2021/03/02
Temporary reduction in daily global CO2 emissions during the COVID-19 forced confinement 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (7) : 647-+
作者:  Le Quere, Corinne;  Jackson, Robert B.;  Jones, Matthew W.;  Smith, Adam J. P.;  Abernethy, Sam;  Andrew, Robbie M.;  De-Gol, Anthony J.;  Willis, David R.;  Shan, Yuli;  Canadell, Josep G.;  Friedlingstein, Pierre;  Creutzig, Felix;  Peters, Glen P.
收藏  |  浏览/下载:22/0  |  提交时间:2020/05/20
Neuronal programming by microbiota regulates intestinal physiology 期刊论文
NATURE, 2020, 578 (7794) : 284-+
作者:  Li, Yilong;  Roberts, Nicola D.;  Wala, Jeremiah A.;  Shapira, Ofer;  Schumacher, Steven E.;  Kumar, Kiran;  Khurana, Ekta;  Waszak, Sebastian;  Korbel, Jan O.;  Haber, James E.;  Imielinski, Marcin;  Weischenfeldt, Joachim;  Beroukhim, Rameen;  Campbell, Peter J.;  Akdemir, Kadir C.;  Alvarez, Eva G.;  Baez-Ortega, Adrian;  Boutros, Paul C.;  Bowtell, David D. L.;  Brors, Benedikt;  Burns, Kathleen H.;  Chan, Kin;  Chen, Ken;  Cortes-Ciriano, Isidro;  Dueso-Barroso, Ana;  Dunford, Andrew J.;  Edwards, Paul A.;  Estivill, Xavier;  Etemadmoghadam, Dariush;  Feuerbach, Lars;  Fink, J. Lynn;  Frenkel-Morgenstern, Milana;  Garsed, Dale W.;  Gerstein, Mark;  Gordenin, Dmitry A.;  Haan, David;  Hess, Julian M.;  Hutter, Barbara;  Jones, David T. W.;  Ju, Young Seok;  Kazanov, Marat D.;  Klimczak, Leszek J.;  Koh, Youngil;  Lee, Eunjung Alice;  Lee, Jake June-Koo;  Lynch, Andy G.;  Macintyre, Geoff;  Markowetz, Florian;  Martincorena, Inigo;  Martinez-Fundichely, Alexander;  Meyerson, Matthew;  Miyano, Satoru;  Nakagawa, Hidewaki;  Navarro, Fabio C. P.;  Ossowski, Stephan;  Park, Peter J.;  Pearson, John, V;  Puiggros, Montserrat;  Rippe, Karsten;  Roberts, Steven A.;  Rodriguez-Martin, Bernardo;  Scully, Ralph;  Shackleton, Mark;  Sidiropoulos, Nikos;  Sieverling, Lina;  Stewart, Chip;  Torrents, David;  Tubio, Jose M. C.;  Villasante, Izar;  Waddell, Nicola;  Yang, Lixing;  Yao, Xiaotong;  Yoon, Sung-Soo;  Zamora, Jorge;  Zhang, Cheng-Zhong
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/03

Neural control of the function of visceral organs is essential for homeostasis and health. Intestinal peristalsis is critical for digestive physiology and host defence, and is often dysregulated in gastrointestinal disorders(1). Luminal factors, such as diet and microbiota, regulate neurogenic programs of gut motility(2-5), but the underlying molecular mechanisms remain unclear. Here we show that the transcription factor aryl hydrocarbon receptor (AHR) functions as a biosensor in intestinal neural circuits, linking their functional output to the microbial environment of the gut lumen. Using nuclear RNA sequencing of mouse enteric neurons that represent distinct intestinal segments and microbiota states, we demonstrate that the intrinsic neural networks of the colon exhibit unique transcriptional profiles that are controlled by the combined effects of host genetic programs and microbial colonization. Microbiota-induced expression of AHR in neurons of the distal gastrointestinal tract enables these neurons to respond to the luminal environment and to induce expression of neuron-specific effector mechanisms. Neuron-specific deletion of Ahr, or constitutive overexpression of its negative feedback regulator CYP1A1, results in reduced peristaltic activity of the colon, similar to that observed in microbiota-depleted mice. Finally, expression of Ahr in the enteric neurons of mice treated with antibiotics partially restores intestinal motility. Together, our experiments identify AHR signalling in enteric neurons as a regulatory node that integrates the luminal environment with the physiological output of intestinal neural circuits to maintain gut homeostasis and health.


In a mouse model, aryl hydrocarbon receptor signalling in enteric neurons is revealed as a mechanism that helps to maintain gut homeostasis by integrating the luminal environment with the physiology of intestinal neural circuits.


  
Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids 期刊论文
NATURE, 2020
作者:  Nixon, Christopher C.;  Mavigner, Maud;  Sampey, Gavin C.;  Brooks, Alyssa D.;  Spagnuolo, Rae Ann;  Irlbeck, David M.;  Mattingly, Cameron;  Ho, Phong T.;  Schoof, Nils;  Cammon, Corinne G.;  Tharp, Greg K.;  Kanke, Matthew;  Wang, Zhang;  Cleary, Rachel A.;  Upadhyay, Amit A.;  De, Chandrav;  Wills, Saintedym R.;  Falcinelli, Shane D.;  Galardi, Cristin;  Walum, Hasse;  Schramm, Nathaniel J.;  Deutsch, Jennifer;  Lifson, Jeffrey D.;  Fennessey, Christine M.;  Keele, Brandon F.;  Jean, Sherrie;  Maguire, Sean;  Liao, Baolin;  Browne, Edward P.;  Ferris, Robert G.;  Brehm, Jessica H.;  Favre, David;  Vanderford, Thomas H.;  Bosinger, Steven E.;  Jones, Corbin D.;  Routy, Jean-Pierre;  Archin, Nancie M.;  Margolis, David M.;  Wahl, Angela;  Dunham, Richard M.;  Silvestri, Guido;  Chahroudi, Ann;  Garcia, J. Victor
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

Single-cell RNA sequencing and spatial transcriptomics reveal that the somitogenesis clock is active in mouse gastruloids, which can be induced to generate somites with the correct rostral-caudal patterning.


Gastruloids are three-dimensional aggregates of embryonic stem cells that display key features of mammalian development after implantation, including germ-layer specification and axial organization(1-3). To date, the expression pattern of only a small number of genes in gastruloids has been explored with microscopy, and the extent to which genome-wide expression patterns in gastruloids mimic those in embryos is unclear. Here we compare mouse gastruloids with mouse embryos using single-cell RNA sequencing and spatial transcriptomics. We identify various embryonic cell types that were not previously known to be present in gastruloids, and show that key regulators of somitogenesis are expressed similarly between embryos and gastruloids. Using live imaging, we show that the somitogenesis clock is active in gastruloids and has dynamics that resemble those in vivo. Because gastruloids can be grown in large quantities, we performed a small screen that revealed how reduced FGF signalling induces a short-tail phenotype in embryos. Finally, we demonstrate that embedding in Matrigel induces gastruloids to generate somites with the correct rostral-caudal patterning, which appear sequentially in an anterior-to-posterior direction over time. This study thus shows the power of gastruloids as a model system for exploring development and somitogenesis in vitro in a high-throughput manner.


  
Embryonal precursors of Wilms tumor 期刊论文
SCIENCE, 2019, 366 (6470) : 1247-+
作者:  Coorens, Tim H. H.;  Treger, Taryn D.;  Al-Saadi, Reem;  Moore, Luiza;  Tran, Maxine G. B.;  Mitchell, Thomas J.;  Tugnait, Suzanne;  Thevanesan, Christine;  Young, Matthew D.;  Oliver, Thomas R. W.;  Oostveen, Minou;  Collord, Grace;  Tarpey, Patrick S.;  Cagan, Alex;  Hooks, Yvette;  Brougham, Mark;  Reynolds, Ben C.;  Barone, Giuseppe;  Anderson, John;  Jorgensen, Mette;  Burke, G. A. Amos;  Visser, Johannes;  Nicholson, James C.;  Smeulders, Naima;  Mushtaq, Imran;  Stewart, Grant D.;  Campbell, Peter J.;  Wedge, David C.;  Martincorena, Inigo;  Rampling, Dyanne;  Hook, Liz;  Warren, Anne Y.;  Coleman, Nicholas;  Chowdhury, Tanzina;  Sebire, Neil;  Drost, Jarno;  Saeb-Parsy, Kourosh;  Stratton, Michael R.;  Straathof, Karin;  Pritchard-Jones, Kathy;  Behjati, Sam
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
Functional interpretation of single cell similarity maps 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  De Tomaso, David;  Jones, Matthew G.;  Subramaniam, Meena;  Ashuach, Tal;  Ye, Chun J.;  Yosef, Nir
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
Quantifying the contribution of recessive coding variation to developmental disorders 期刊论文
SCIENCE, 2018, 362 (6419) : 1161-+
作者:  Martin, Hilary C.;  Jones, Wendy D.;  McIntyre, Rebecca;  Sanchez-Andrade, Gabriela;  Sanderson, Mark;  Stephenson, James D.;  Jones, Carla P.;  Handsaker, Juliet;  Gallone, Giuseppe;  Bruntraeger, Michaela;  McRae, Jeremy F.;  Prigmore, Elena;  Short, Patrick;  Niemi, Mari;  Kaplanis, Joanna;  Radford, Elizabeth J.;  Akavvi, Nadia;  Balasubramanian, Meena;  Dean, John;  Horton, Rachel;  Hulbert, Alice;  Johnson, Diana S.;  Johnson, Katie;  Kumar, Dhavendra;  Lynch, Sally Ann;  Mehta, Sarju G.;  Morton, Jenny;  Parker, Michael J.;  Splitt, Miranda;  Turnpenny, Peter D.;  Vasudevan, Pradeep C.;  Wright, Michael;  Bassett, Andrew;  Gerety, Sebastian S.;  Wright, Caroline F.;  FitzPatrick, David R.;  Firth, Helen, V;  Hurles, Matthew E.;  Barrett, Jeffrey C.
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Daytime HONO, NO2 and aerosol distributions from MAX-DOAS observations in Melbourne 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (19) : 13969-13985
作者:  Ryan, Robert G.;  Rhodes, Steve;  Tully, Matthew;  Wilson, Stephen;  Jones, Nicholas;  Friess, Udo;  Schofield, Robyn
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Latitudinal limits to the predicted increase of the peatland carbon sink with warming 期刊论文
NATURE CLIMATE CHANGE, 2018, 8 (10) : 907-+
作者:  Gallego-Sala, Angela, V;  Charman, Dan J.;  Brewer, Simon;  Page, Susan E.;  Prentice, I. Colin;  Friedlingstein, Pierre;  Moreton, Steve;  Amesbury, Matthew J.;  Beilman, David W.;  Bjorck, Svante;  Blyakharchuk, Tatiana;  Bochicchio, Christopher;  Booth, Robert K.;  Bunbury, Joan;  Camill, Philip;  Carless, Donna;  Chimner, Rodney A.;  Clifford, Michael;  Cressey, Elizabeth;  Courtney-Mustaphi, Colin;  De Vleeschouwer, Francois;  de Jong, Rixt;  Fialkiewicz-Koziel, Barbara;  Finkelstein, Sarah A.;  Garneau, Michelle;  Githumbi, Esther;  Hribjlan, John;  Holmquist, James;  Hughes, Paul D. M.;  Jones, Chris;  Jones, Miriam C.;  Karofeld, Edgar;  Klein, Eric S.;  Kokfelt, Ulla;  Korhola, Atte;  Lacourse, Terri;  Le Roux, Gael;  Lamentowicz, Mariusz;  Large, David;  Lavoie, Martin;  Loisel, Julie;  Mackay, Helen;  MacDonald, Glen M.;  Makila, Markku;  Magnan, Gabriel;  Marchant, Robert;  Marcisz, Katarzyna;  Martinez Cortizas, Antonio;  Massa, Charly;  Mathijssen, Paul;  Mauquoy, Dmitri;  Mighall, Timothy;  Mitchell, Fraser J. G.;  Moss, Patrick;  Nichols, Jonathan;  Oksanen, Pirita O.;  Orme, Lisa;  Packalen, Maara S.;  Robinson, Stephen;  Roland, Thomas P.;  Sanderson, Nicole K.;  Sannel, A. Britta K.;  Silva-Sanchez, Noemi;  Steinberg, Natascha;  Swindles, Graeme T.;  Turner, T. Edward;  Uglow, Joanna;  Valiranta, Minna;  van Bellen, Simon;  van der Linden, Marjolein;  van Geel, Bas;  Wang, Guoping;  Yu, Zicheng;  Zaragoza-Castells, Joana;  Zhao, Yan
收藏  |  浏览/下载:16/0  |  提交时间:2019/04/09