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The hepatocyte clock and feeding control chronophysiology of multiple liver cell types 期刊论文
Science, 2020
作者:  Dongyin Guan;  Ying Xiong;  Trang Minh Trinh;  Yang Xiao;  Wenxiang Hu;  Chunjie Jiang;  Pieterjan Dierickx;  Cholsoon Jang;  Joshua D. Rabinowitz;  Mitchell A. Lazar
收藏  |  浏览/下载:7/0  |  提交时间:2020/09/14
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic 期刊论文
Science, 2020
作者:  Emily N. Chin;  Chenguang Yu;  Vincent F. Vartabedian;  Ying Jia;  Manoj Kumar;  Ana M. Gamo;  William Vernier;  Sabrina H. Ali;  Mildred Kissai;  Daniel C. Lazar;  Nhan Nguyen;  Laura E. Pereira;  Brent Benish;  Ashley K. Woods;  Sean B. Joseph;  Alan Chu;  Kristen A. Johnson;  Philipp N. Sander;  Francisco Martínez-Peña;  Eric N. Hampton;  Travis S. Young;  Dennis W. Wolan;  Arnab K. Chatterjee;  Peter G. Schultz;  H. Michael Petrassi;  John R. Teijaro;  Luke L. Lairson
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/25
Premature mortality related to United States cross-state air pollution 期刊论文
NATURE, 2020, 578 (7794) : 261-+
作者:  Helmink, Beth A.;  Reddy, Sangeetha M.;  Gao, Jianjun;  Zhang, Shaojun;  Basar, Rafet;  Thakur, Rohit;  Yizhak, Keren;  Sade-Feldman, Moshe;  Blando, Jorge;  Han, Guangchun;  Gopalakrishnan, Vancheswaran;  Xi, Yuanxin;  Zhao, Hao;  Amaria, Rodabe N.;  Tawbi, Hussein A.;  Cogdill, Alex P.;  Liu, Wenbin;  LeBleu, Valerie S.;  Kugeratski, Fernanda G.;  Patel, Sapna;  Davies, Michael A.;  Hwu, Patrick;  Lee, Jeffrey E.;  Gershenwald, Jeffrey E.;  Lucci, Anthony;  Arora, Reetakshi;  Woodman, Scott;  Keung, Emily Z.;  Gaudreau, Pierre-Olivier;  Reuben, Alexandre;  Spencer, Christine N.;  Burton, Elizabeth M.;  Haydu, Lauren E.;  Lazar, Alexander J.;  Zapassodi, Roberta;  Hudgens, Courtney W.;  Ledesma, Deborah A.;  Ong, SuFey;  Bailey, Michael;  Warren, Sarah;  Rao, Disha;  Krijgsman, Oscar;  Rozeman, Elisa A.;  Peeper, Daniel;  Blank, Christian U.;  Schumacher, Ton N.;  Butterfield, Lisa H.;  Zelazowska, Monika A.;  McBride, Kevin M.;  Kalluri, Raghu;  Allison, James;  Petitprez, Florent;  Fridman, Wolf Herman;  Sautes-Fridman, Catherine;  Hacohen, Nir;  Rezvani, Katayoun;  Sharma, Padmanee;  Tetzlaff, Michael T.;  Wang, Linghua;  Wargo, Jennifer A.
收藏  |  浏览/下载:37/0  |  提交时间:2020/05/13

Outdoor air pollution adversely affects human health and is estimated to be responsible for five to ten per cent of the total annual premature mortality in the contiguous United States(1-3). Combustion emissions from a variety of sources, such as power generation or road traffic, make a large contribution to harmful air pollutants such as ozone and fine particulate matter (PM2.5)(4). Efforts to mitigate air pollution have focused mainly on the relationship between local emission sources and local air quality(2). Air quality can also be affected by distant emission sources, however, including emissions from neighbouring federal states(5,6). This cross-state exchange of pollution poses additional regulatory challenges. Here we quantify the exchange of air pollution among the contiguous United States, and assess its impact on premature mortality that is linked to increased human exposure to PM2.5 and ozone from seven emission sectors for 2005 to 2018. On average, we find that 41 to 53 per cent of air-quality-related premature mortality resulting from a state'  s emissions occurs outside that state. We also find variations in the cross-state contributions of different emission sectors and chemical species to premature mortality, and changes in these variations over time. Emissions from electric power generation have the greatest cross-state impacts as a fraction of their total impacts, whereas commercial/residential emissions have the smallest. However, reductions in emissions from electric power generation since 2005 have meant that, by 2018, cross-state premature mortality associated with the commercial/residential sector was twice that associated with power generation. In terms of the chemical species emitted, nitrogen oxides and sulfur dioxide emissions caused the most cross-state premature deaths in 2005, but by 2018 primary PM2.5 emissions led to cross-state premature deaths equal to three times those associated with sulfur dioxide emissions. These reported shifts in emission sectors and emission species that contribute to premature mortality may help to guide improvements to air quality in the contiguous United States.


  
First Evidence of Anoxia and Nitrogen Loss in the Southern Canary Upwelling System 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (5) : 2619-2627
作者:  Machu, E.;  Capet, X.;  Estrade, P. A.;  Ndoye, S.;  Brajard, J.;  Baurand, F.;  Auger, P. -A.;  Lazar, A.;  Brehmer, P.
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
oxygen  canary upwelling system  anoxia  denitrification  shallow continental shelf  
Rev-erb alpha dynamically modulates chromatin looping to control circadian gene transcription 期刊论文
SCIENCE, 2018, 359 (6381) : 1274-+
作者:  Kim, Yong Hoon;  Marhon, Sajid A.;  Zhang, Yuxiang;  Steger, David J.;  Won, Kyoung-Jae;  Lazar, Mitchell A.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients 期刊论文
SCIENCE, 2018, 359 (6371) : 97-103
作者:  Gopalakrishnan, V.;  Spencer, C. N.;  Nezi, L.;  Reuben, A.;  Andrews, M. C.;  Karpinets, T. V.;  Prieto, P. A.;  Vicente, D.;  Hoffman, K.;  Wei, S. C.;  Cogdill, A. P.;  Zhao, L.;  Hudgens, C. W.;  Hutchinson, D. S.;  Manzo, T.;  de Macedo, M. Petaccia;  Cotechini, T.;  Kumar, T.;  Chen, W. S.;  Reddy, S. M.;  Sloane, R. Szczepaniak;  Galloway-Pena, J.;  Jiang, H.;  Chen, P. L.;  Shpall, E. J.;  Rezvani, K.;  Alousi, A. M.;  Chemaly, R. F.;  Shelburne, S.;  Vence, L. M.;  Okhuysen, P. C.;  Jensen, V. B.;  Swennes, A. G.;  McAllister, F.;  Sanchez, E. Marcelo Riquelme;  Zhang, Y.;  Le Chatelier, E.;  Zitvogel, L.;  Pons, N.;  Austin-Breneman, J. L.;  Haydu, L. E.;  Burton, E. M.;  Gardner, J. M.;  Sirmans, E.;  Hu, J.;  Lazar, A. J.;  Tsujikawa, T.;  Diab, A.;  Tawbi, H.;  Glitza, I. C.;  Hwu, W. J.;  Patel, S. P.;  Woodman, S. E.;  Amaria, R. N.;  Davies, M. A.;  Gershenwald, J. E.;  Hwu, P.;  Lee, J. E.;  Zhang, J.;  Coussens, L. M.;  Cooper, Z. A.;  Futreal, P. A.;  Daniel, C. R.;  Ajami, N. J.;  Petrosino, J. F.;  Tetzlaff, M. T.;  Sharma, P.;  Allison, J. P.;  Jenq, R. R.;  Wargo, J. A.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge 期刊论文
NATURE, 2017, 546 (7659) : 544-+
作者:  Emmett, Matthew J.;  Lim, Hee-Woong;  Jager, Jennifer;  Richter, Hannah J.;  Adlanmerini, Marine;  Peed, Lindsey C.;  Briggs, Erika R.;  Steger, David J.;  Ma, Tao;  Sims, Carrie A.;  Baur, Joseph A.;  Pei, Liming;  Won, Kyoung-Jae;  Seale, Patrick;  Gerhart-Hines, Zachary;  Lazar, Mitchell A.
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Architecture of collapse: regime shift and recovery in an hierarchically structured marine ecosystem 期刊论文
GLOBAL CHANGE BIOLOGY, 2017, 23 (4)
作者:  Daskalov, Georgi M.;  Boicenco, Laura;  Grishin, Alexandre N.;  Lazar, Luminita;  Mihneva, Vesselina;  Shlyakhov, Vladislav A.;  Zengin, Mustafa
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
ecosystem hierarchy  ecosystem management  hierarchical incorporation  hypoxia  integrated ecosystem assessment  invasive species  overfishing  predator  regime shift  trophic cascade  
Regeneration of fat cells from myofibroblasts during wound healing 期刊论文
SCIENCE, 2017, 355 (6326) : 748-+
作者:  Plikus, Maksim V.;  Guerrero-Juarez, Christian F.;  Ito, Mayumi;  Li, Yun Rose;  Dedhia, Priya H.;  Zheng, Ying;  Shao, Mengle;  Gay, Denise L.;  Ramos, Raul;  Hsi, Tsai-Ching;  Oh, Ji Won;  Wang, Xiaojie;  Ramirez, Amanda;  Konopelski, Sara E.;  Elzein, Arijh;  Wang, Anne;  Supapannachart, Rarinthip June;  Lee, Hye-Lim;  Lim, Chae Ho;  Nace, Arben;  Guo, Amy;  Treffeisen, Elsa;  Andl, Thomas;  Ramirez, Ricardo N.;  Murad, Rabi;  Offermanns, Stefan;  Metzger, Daniel;  Chambon, Pierre;  Widgerow, Alan D.;  Tuan, Tai-Lan;  Mortazavi, Ali;  Gupta, Rana K.;  Hamilton, Bruce A.;  Millar, Sarah E.;  Seale, Patrick;  Pear, Warren S.;  Lazar, Mitchell A.;  Cotsarelis, George
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Department of Energy’s ARM Climate Research Facility External Data Center Operations Plan Located At Brookhaven National Laboratory 科技报告
来源:US Department of Energy (DOE). 出版年: 2015
作者:  Cialella, A.;  Gregory, L.;  Lazar, K.;  Liang, M.;  Ma, L.;  Tilp, A.;  Wagener, R.
收藏  |  浏览/下载:1/0  |  提交时间:2019/04/05