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Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract 期刊论文
Nature Communications, 2022
作者:  Zhang, Jianan;  Walker, Morgan E.;  Sanidad, Katherine Z.;  Zhang, Hongna;  Liang, Yanshan;  Zhao, Ermin;  Chacon-Vargas, Katherine;  Yeliseyev, Vladimir;  Parsonnet, Julie;  Haggerty, Thomas D.;  Wang, Guangqiang;  Simpson, Joshua B.;  Jariwala, Parth B.;  Beaty, Violet V.;  Yang, Jun;  Yang, Haixia;  Panigrahy, Anand;  Minter, Lisa M.;  Kim, Daeyoung;  Gibbons, John G.;  Liu, LinShu;  Li, Zhengze;  Xiao, Hang;  Borlandelli, Valentina;  Overkleeft, Hermen S.;  Cloer, Erica W.;  Major, Michael B.;  Goldfarb, Dennis;  Cai, Zongwei;  Redinbo, Matthew R.;  Zhang, Guodong
收藏  |  浏览/下载：17/0  |  提交时间：2022/01/29
De novo assembly, annotation, and comparative analysis of 26 diverse maize genomes 期刊论文
Science, 2021
作者:  Matthew B. Hufford;  Arun S. Seetharam;  Margaret R. Woodhouse;  Kapeel M. Chougule;  Shujun Ou;  Jianing Liu;  William A. Ricci;  Tingting Guo;  Andrew Olson;  Yinjie Qiu;  Rafael Della Coletta;  Silas Tittes;  Asher I. Hudson;  Alexandre P. Marand;  Sharon Wei;  Zhenyuan Lu;  Bo Wang;  Marcela K. Tello-Ruiz;  Rebecca D. Piri;  Na Wang;  Dong won Kim;  Yibing Zeng;  Christine H. O’Connor;  Xianran Li;  Amanda M. Gilbert;  Erin Baggs;  Ksenia V. Krasileva;  John L. Portwood;  Ethalinda K. S. Cannon;  Carson M. Andorf;  Nancy Manchanda;  Samantha J. Snodgrass;  David E. Hufnagel;  Qiuhan Jiang;  Sarah Pedersen;  Michael L. Syring;  David A. Kudrna;  Victor Llaca;  Kevin Fengler;  Robert J. Schmitz;  Jeffrey Ross-Ibarra;  Jianming Yu;  Jonathan I. Gent;  Candice N. Hirsch;  Doreen Ware;  R. Kelly Dawe
收藏  |  浏览/下载：18/0  |  提交时间：2021/08/10
Upper mantle structure of Mars from InSight seismic data 期刊论文
Science, 2021
作者:  Amir Khan;  Savas Ceylan;  Martin van Driel;  Domenico Giardini;  Philippe Lognonné;  Henri Samuel;  Nicholas C. Schmerr;  Simon C. Stähler;  Andrea C. Duran;  Quancheng Huang;  Doyeon Kim;  Adrien Broquet;  Constantinos Charalambous;  John F. Clinton;  Paul M. Davis;  Mélanie Drilleau;  Foivos Karakostas;  Vedran Lekic;  Scott M. McLennan;  Ross R. Maguire;  Chloé Michaut;  Mark P. Panning;  William T. Pike;  Baptiste Pinot;  Matthieu Plasman;  John-Robert Scholz;  Rudolf Widmer-Schnidrig;  Tilman Spohn;  Suzanne E. Smrekar;  William B. Banerdt
收藏  |  浏览/下载：17/0  |  提交时间：2021/07/27
Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events 期刊论文
Science, 2021
作者:  Jacob E. Lemieux;  Katherine J. Siddle;  Bennett M. Shaw;  Christine Loreth;  Stephen F. Schaffner;  Adrianne Gladden-Young;  Gordon Adams;  Timelia Fink;  Christopher H. Tomkins-Tinch;  Lydia A. Krasilnikova;  Katherine C. DeRuff;  Melissa Rudy;  Matthew R. Bauer;  Kim A. Lagerborg;  Erica Normandin;  Sinéad B. Chapman;  Steven K. Reilly;  Melis N. Anahtar;  Aaron E. Lin;  Amber Carter;  Cameron Myhrvold;  Molly E. Kemball;  Sushma Chaluvadi;  Caroline Cusick;  Katelyn Flowers;  Anna Neumann;  Felecia Cerrato;  Maha Farhat;  Damien Slater;  Jason B. Harris;  John A. Branda;  David Hooper;  Jessie M. Gaeta;  Travis P. Baggett;  James O’Connell;  Andreas Gnirke;  Tami D. Lieberman;  Anthony Philippakis;  Meagan Burns;  Catherine M. Brown;  Jeremy Luban;  Edward T. Ryan;  Sarah E. Turbett;  Regina C. LaRocque;  William P. Hanage;  Glen R. Gallagher;  Lawrence C. Madoff;  Sandra Smole;  Virginia M. Pierce;  Eric Rosenberg;  Pardis C. Sabeti;  Daniel J. Park;  Bronwyn L. MacInnis
收藏  |  浏览/下载：18/0  |  提交时间：2021/02/17
Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau 期刊论文
Science, 2020
作者:  Nabil F. Darwich;  Jessica M. Phan;  Boram Kim;  EunRan Suh;  John D. Papatriantafyllou;  Lakshmi Changolkar;  Aivi T. Nguyen;  Caroline M. O’Rourke;  Zhuohao He;  Sílvia Porta;  Garrett S. Gibbons;  Kelvin C. Luk;  Sokratis G. Papageorgiou;  Murray Grossman;  Lauren Massimo;  David J. Irwin;  Corey T. McMillan;  Ilya M. Nasrallah;  Camilo Toro;  Geoffrey K. Aguirre;  Vivianna M. Van Deerlin;  Edward B. Lee
收藏  |  浏览/下载：9/0  |  提交时间：2020/11/24
Spatial patterns and trends of summertime low cloudiness for the Pacific Northwest, 1996‐2017 期刊论文
Geophysical Research Letters, 2020
作者:  Alex W. Dye;  Bharat Rastogi;  Rachel E. S. Clemesha;  John B. Kim;  Roger M. Samelson;  Christopher J. Still;  A. Park Williams
收藏  |  浏览/下载：8/0  |  提交时间：2020/08/18
Agricultural acceleration of soil carbonate weathering 期刊论文
Global Change Biology, 2020
作者:  John H. Kim;  Esteban G. Jobbá;  gy;  Daniel D. Richter;  Susan E. Trumbore;  Robert B. Jackson
收藏  |  浏览/下载：21/0  |  提交时间：2020/08/09
Constraining remote oxidation capacity with ATom observations 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 7753-7781
作者:  Travis, Katherine R.;  Heald, Colette L.;  Allen, Hannah M.;  Apel, Eric C.;  Arnold, Stephen R.;  Blake, Donald R.;  Brune, William H.;  Chen, Xin;  Commane, Roisin;  Crounse, John D.;  Daube, Bruce C.;  Diskin, Glenn S.;  Elkins, James W.;  Evans, Mathew J.;  Hall, Samuel R.;  Hintsa, Eric J.;  Hornbrook, Rebecca S.;  Kasibhatla, Prasad S.;  Kim, Michelle J.;  Luo, Gan;  McKain, Kathryn;  Millet, Dylan B.;  Moore, Fred L.;  Peischl, Jeffrey;  Ryerson, Thomas B.;  Sherwen, Tomas;  Thames, Alexander B.;  Ullmann, Kirk;  Wang, Xuan;  Wennberg, Paul O.;  Wolfe, Glenn M.;  Yu, Fangqun
收藏  |  浏览/下载：48/0  |  提交时间：2020/08/18
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Missing OH reactivity in the global marine boundary layer 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 4013-4029
作者:  Thames, Alexander B.;  Brune, William H.;  Miller, David O.;  Allen, Hannah M.;  Apel, Eric C.;  Blake, Donald R.;  Bui, T. Paul;  Commane, Roisin;  Crounse, John D.;  Daube, Bruce C.;  Diskin, Glenn S.;  DiGangi, Joshua P.;  Elkins, JamesW.;  Hall, Samuel R.;  Hanisco, Thomas F.;  Hannun, Reem A.;  Hintsa, Eric;  Hornbrook, Rebecca S.;  Kim, Michelle J.;  McKain, Kathryn;  Moore, Fred L.;  Nicely, Julie M.;  Peischl, Jeffrey;  Ryerson, Thomas B.;  St Clair, Jason M.;  Sweeney, Colm;  Teng, Alex;  Thompson, Chelsea R.;  Ullmann, Kirk;  Wennberg, Paul O.;  Wolfe, Glenn M.
收藏  |  浏览/下载：14/0  |  提交时间：2020/07/02