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Microbial signatures in tumours and blood 期刊论文
NATURE, 2020, 579 (7800) : 502-503
作者:  Goodman, Russell P.;  Markhard, Andrew L.;  Shah, Hardik;  Sharma, Rohit;  Skinner, Owen S.;  Clish, Clary B.;  Deik, Amy;  Patgiri, Anupam;  Hsu, Yu-Han H.;  Masia, Ricard;  Noh, Hye Lim;  Suk, Sujin;  Goldberger, Olga;  Hirschhorn, Joel N.;  Yellen, Gary;  Kim, Jason K.;  Mootha, Vamsi K.
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

Microbiome signatures as putative cancer diagnostics.


Analysis of nucleic-acid sequences from human cancers, along with samples from adjacent tissue and blood, reveals the presence of microorganisms in tumours and blood across cancers.


  
Evaluation of methods for causal discovery in hydrometeorological systems 期刊论文
Water Resources Research, 2020
作者:  M. Ombadi;  P. Nguyen;  S. Sorooshian;  K. Hsu
收藏  |  浏览/下载:1/0  |  提交时间:2020/05/20
Origin of complexity in haemoglobin evolution 期刊论文
NATURE, 2020
作者:  Cheema, Suraj S.;  Kwon, Daewoong;  Shanker, Nirmaan;  dos Reis, Roberto;  Hsu, Shang-Lin;  Xiao, Jun;  Zhang, Haigang;  Wagner, Ryan;  Datar, Adhiraj;  McCarter, Margaret R.;  Serrao, Claudy R.;  Yadav, Ajay K.;  Karbasian, Golnaz;  Hsu, Cheng-Hsiang;  Tan, Ava J.;  Wang, Li-Chen;  Thakare, Vishal;  Zhang, Xiang;  Mehta, Apurva;  Karapetrova, Evguenia;  Chopdekar, Rajesh, V;  Shafer, Padraic;  Arenholz, Elke;  Hu, Chenming;  Proksch, Roger;  Ramesh, Ramamoorthy;  Ciston, Jim;  Salahuddin, Sayeef
收藏  |  浏览/下载:50/0  |  提交时间:2020/07/03

Most proteins associate into multimeric complexes with specific architectures(1,2), which often have functional properties such as cooperative ligand binding or allosteric regulation(3). No detailed knowledge is available about how any multimer and its functions arose during evolution. Here we use ancestral protein reconstruction and biophysical assays to elucidate the origins of vertebrate haemoglobin, a heterotetramer of paralogous alpha- and beta-subunits that mediates respiratory oxygen transport and exchange by cooperatively binding oxygen with moderate affinity. We show that modern haemoglobin evolved from an ancient monomer and characterize the historical '  missing link'  through which the modern tetramer evolved-a noncooperative homodimer with high oxygen affinity that existed before the gene duplication that generated distinct alpha- and beta-subunits. Reintroducing just two post-duplication historical substitutions into the ancestral protein is sufficient to cause strong tetramerization by creating favourable contacts with more ancient residues on the opposing subunit. These surface substitutions markedly reduce oxygen affinity and even confer cooperativity, because an ancient linkage between the oxygen binding site and the multimerization interface was already an intrinsic feature of the protein'  s structure. Our findings establish that evolution can produce new complex molecular structures and functions via simple genetic mechanisms that recruit existing biophysical features into higher-level architectures.


Experimental analysis of reconstructed ancestral globins reveals that haemoglobin'  s complex tetrameric structure and oxygen-binding functions evolved by simple genetic and biophysical mechanisms.


  
HO2 Generation Above Sprite-Producing Thunderstorms Derived from Low-Noise SMILES Observation Spectra 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (3)
作者:  Yamada, T.;  Sato, T. O.;  Adachi, T.;  Winkler, H.;  Kuribayashi, K.;  Larsson, R.;  Yoshida, N.;  Takahashi, Y.;  Sato, M.;  Chen, A. B.;  Hsu, R. R.;  Nakano, Y.;  Fujinawa, T.;  Nara, S.;  Uchiyama, Y.;  Kasai, Y.
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/02
Current-driven magnetic domain-wall logic 期刊论文
NATURE, 2020, 579 (7798) : 214-+
作者:  Culp, Elizabeth J.;  Waglechner, Nicholas;  Wang, Wenliang;  Fiebig-Comyn, Aline A.;  Hsu, Yen-Pang;  Koteva, Kalinka;  Sychantha, David;  Coombes, Brian K.;  Van Nieuwenhze, Michael S.;  Brun, Yves, V;  Wright, Gerard D.
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/03

Spin-based logic architectures provide nonvolatile data retention, near-zero leakage, and scalability, extending the technology roadmap beyond complementary metal-oxide-semiconductor logic(1-13). Architectures based on magnetic domain walls take advantage of the fast motion, high density, non-volatility and flexible design of domain walls to process and store information(1,3,14-16). Such schemes, however, rely on domain-wall manipulation and clocking using an external magnetic field, which limits their implementation in dense, large-scale chips. Here we demonstrate a method for performing all-electric logic operations and cascading using domain-wall racetracks. We exploit the chiral coupling between neighbouring magnetic domains induced by the interfacial Dzyaloshinskii-Moriya interaction(17-20), which promotes non-collinear spin alignment, to realize a domain-wall inverter, the essential basic building block in all implementations of Boolean logic. We then fabricate reconfigurable NAND and NOR logic gates, and perform operations with current-induced domain-wall motion. Finally, we cascade several NAND gates to build XOR and full adder gates, demonstrating electrical control of magnetic data and device interconnection in logic circuits. Our work provides a viable platform for scalable all-electric magnetic logic, paving the way for memory-in-logic applications.


  
On the Mechanisms of the Active 2018 Tropical Cyclone Season in the North Pacific 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Qian, Y.;  Morakami, H.;  Nakano, M.;  Hsu, P-C;  Delworth, T. L.;  Kapnick, S. B.;  Ramaswamy, V;  Mochizuki, T.;  Morioka, Y.;  Doi, T.;  Kataoka, T.;  Nasuno, T.;  Yoshida, K.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
tropical cyclones  North Pacific  Pacific Meridional Mode  central Pacific El Nino  future change  extreme events  
Close Cassini flybys of Saturn's ring moons Pan, Daphnis, Atlas, Pandora, and Epimetheus 期刊论文
SCIENCE, 2019, 364 (6445) : 1053-+
作者:  Buratti, B. J.;  Thomas, P. C.;  Roussos, E.;  Howett, C.;  Seiss, M.;  Hendrix, A. R.;  Helfenstein, P.;  Brown, R. H.;  Clark, R. N.;  Denk, T.;  Filacchione, G.;  Hoffmann, H.;  Jones, G. H.;  Khawaja, N.;  Kollmann, P.;  Krupp, N.;  Lunine, J.;  Momary, T. W.;  Paranicas, C.;  Postberg, F.;  Sachse, M.;  Spahn, F.;  Spencer, J.;  Srama, R.;  Albin, T.;  Baines, K. H.;  Ciarniello, M.;  Economou, T.;  Hsu, H. -W.;  Kempf, S.;  Krimigis, S. M.;  Mitchell, D.;  Moragas-Klostermeyer, G.;  Nicholson, P. D.;  Porco, C. C.;  Rosenberg, H.;  Simolka, J.;  Soderblom, L. A.
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Material Flux From the Rings of Saturn Into Its Atmosphere 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (19) : 10093-10100
作者:  Perry, M. E.;  Waite, J. H., Jr.;  Mitchell, D. G.;  Miller, K. E.;  Cravens, T. E.;  Perryman, R. S.;  Moore, L.;  Yelle, R. V.;  Hsu, H. -W.;  Hedman, M. M.;  Cuzzi, J. N.;  Strobel, D. F.;  Hamil, O. Q.;  Glein, C. R.;  Paxton, L. J.;  Teolis, B. D.;  McNutt, R. L., Jr.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Comparing the Performance of the NEEWS Earthquake Early Warning System Against the CWB System During the 6 February 2018 M(w)6.2 Hualien Earthquake 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (12) : 6001-6007
作者:  Hsu, T. Y.;  Lin, P. Y.;  Wang, H. H.;  Chiang, H. W.;  Chang, Y. W.;  Kuo, C. H.;  Lin, C. M.;  Wen, K. L.
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
Seasonality of the mass concentration and chemical composition of aerosols around an urbanized basin in East Asia 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2017, 122 (3)
作者:  Chou, C. C. -K.;  Hsu, W. -C.;  Chang, S. -Y.;  Chen, W. -N.;  Chen, M. -J.;  Huang, W. -R.;  Huang, S. -H.;  Tsai, C. -Y.;  Chang, S. -C.;  Lee, C. -T.;  Liu, S. -C.
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09