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A noncoding RNA modulator potentiates phenylalanine metabolism in mice 期刊论文
Science, 2021
作者:  Yajuan Li;  Zhi Tan;  Yaohua Zhang;  Zhao Zhang;  Qingsong Hu;  Ke Liang;  Yao Jun;  Youqiong Ye;  Yi-Chuan Li;  Chunlai Li;  Lan Liao;  Jianming Xu;  Zhen Xing;  Yinghong Pan;  Sujash S. Chatterjee;  Tina K. Nguyen;  Heidi Hsiao;  Sergey D. Egranov;  Nagireddy Putluri;  Cristian Coarfa;  David H. Hawke;  Preethi H. Gunaratne;  Kuang-Lei Tsai;  Leng Han;  Mien-Chie Hung;  George A. Calin;  Fares Namour;  Jean-Louis Guéant;  Ania C. Muntau;  Nenad Blau;  V. Reid Sutton;  Manuel Schiff;  François Feillet;  Shuxing Zhang;  Chunru Lin;  Liuqing Yang
收藏  |  浏览/下载:16/0  |  提交时间:2021/08/10
Electrical manipulation of a topological antiferromagnetic state 期刊论文
NATURE, 2020, 580 (7805) : 608-+
作者:  Chabon, Jacob J.;  Hamilton, Emily G.;  Kurtz, David M.;  Esfahani, Mohammad S.;  Moding, Everett J.;  Stehr, Henning;  Schroers-Martin, Joseph;  Nabet, Barzin Y.;  Chen, Binbin;  Chaudhuri, Aadel A.;  Liu, Chih Long;  Hui, Angela B.;  Jin, Michael C.;  Azad, Tej D.;  Almanza, Diego;  Jeon, Young-Jun;  Nesselbush, Monica C.;  Keh, Lyron Co Ting;  Bonilla, Rene F.;  Yoo, Christopher H.;  Ko, Ryan B.;  Chen, Emily L.;  Merriott, David J.;  Massion, Pierre P.;  Mansfield, Aaron S.;  Jen, Jin;  Ren, Hong Z.;  Lin, Steven H.;  Costantino, Christina L.;  Burr, Risa;  Tibshirani, Robert;  Gambhir, Sanjiv S.;  Berry, Gerald J.;  Jensen, Kristin C.;  West, Robert B.;  Neal, Joel W.;  Wakelee, Heather A.;  Loo, Billy W., Jr.;  Kunder, Christian A.;  Leung, Ann N.;  Lui, Natalie S.;  Berry, Mark F.;  Shrager, Joseph B.;  Nair, Viswam S.;  Haber, Daniel A.;  Sequist, Lecia V.;  Alizadeh, Ash A.;  Diehn, Maximilian
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

Room-temperature electrical switching of a topological antiferromagnetic state in polycrystalline Mn3Sn thin films is demonstrated using the same protocol as that used for conventional ferromagnetic metals.


Electrical manipulation of phenomena generated by nontrivial band topology is essential for the development of next-generation technology using topological protection. A Weyl semimetal is a three-dimensional gapless system that hosts Weyl fermions as low-energy quasiparticles(1-4). It has various exotic properties, such as a large anomalous Hall effect (AHE) and chiral anomaly, which are robust owing to the topologically protected Weyl nodes(1-16). To manipulate such phenomena, a magnetic version of Weyl semimetals would be useful for controlling the locations of Weyl nodes in the Brillouin zone. Moreover, electrical manipulation of antiferromagnetic Weyl metals would facilitate the use of antiferromagnetic spintronics to realize high-density devices with ultrafast operation(17,18). However, electrical control of a Weyl metal has not yet been reported. Here we demonstrate the electrical switching of a topological antiferromagnetic state and its detection by the AHE at room temperature in a polycrystalline thin film(19) of the antiferromagnetic Weyl metal Mn3Sn9,10,12,20, which exhibits zero-field AHE. Using bilayer devices composed of Mn3Sn and nonmagnetic metals, we find that an electrical current density of about 10(10) to 10(11) amperes per square metre induces magnetic switching in the nonmagnetic metals, with a large change in Hall voltage. In addition, the current polarity along the bias field and the sign of the spin Hall angle of the nonmagnetic metals-positive for Pt (ref. (21)), close to 0 for Cu and negative for W (ref. (22))-determines the sign of the Hall voltage. Notably, the electrical switching in the antiferromagnet is achieved with the same protocol as that used for ferromagnetic metals(23,24). Our results may lead to further scientific and technological advances in topological magnetism and antiferromagnetic spintronics.


  
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:34/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
A homing system targets therapeutic T cells to brain cancer (Retraction Article, vol 561, pg 331, 2018) (Retraction of Vol 561, Pg 331, 2018) 期刊论文
NATURE, 2019, 567 (7746) : 132-132
作者:  Samaha, Heba;  Pignata, Antonella;  Fousek, Kristen;  Ren, Jun;  Lam, Fong W.;  Stossi, Fabio;  Dubrulle, Julien;  Salsman, Vita S.;  Krishnan, Shanmugarajan;  Hong, Sung-Ha;  Baker, Matthew L.;  Shree, Ankita;  Gad, Ahmed Z.;  Shum, Thomas;  Fukumura, Dai;  Byrd, Tiara T.;  Mukherjee, Malini;  Marrelli, Sean P.;  Orange, Jordan S.;  Joseph, Sujith K.;  Sorensen, Poul H.;  Taylor, Michael D.;  Hegde, Meenakshi;  Mamonkin, Maksim;  Jain, Rakesh K.;  El-Naggar, Shahenda;  Ahmed, Nabil
收藏  |  浏览/下载:16/0  |  提交时间:2019/11/27
A sudden end-Permian mass extinction in South China 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2019, 131: 205-223
作者:  Shen, Shu-Zhong;  Ramezani, Jahandar;  Chen, Jun;  Cao, Chang-Qun;  Erwin, Douglas H.;  Zhang, Hua;  Xiang, Lei;  Schoepfer, Shane D.;  Henderson, Charles M.;  Zheng, Quan-Feng;  Bowring, Samuel A.;  Wang, Yue;  Li, Xian-Hua;  Wang, Xiang-Dong;  Yuan, Dong-Xun;  Zhang, Yi-Chun;  Mu, Lin;  Wang, Jun;  Wu, Ya-Sheng
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
The multiple merger assembly of a hyperluminous obscured quasar at redshift 4.6 期刊论文
SCIENCE, 2018, 362 (6418) : 1034-+
作者:  Diaz-Santos, T.;  Assef, R. J.;  Blain, A. W.;  Aravena, M.;  Stern, D.;  Tsai, C. -W.;  Eisenhardt, P.;  Wu, J.;  Jun, H. D.;  Dibert, K.;  Inami, H.;  Lansbury, G.;  Leclercq, F.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Regional Similarities and NOx-Related Increases in Biogenic Secondary Organic Aerosol in Summertime Southeastern United States 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (18) : 10620-10636
作者:  Liu, Jun;  Russell, Lynn M.;  Ruggeri, Giulia;  Takahama, Satoshi;  Claflin, Megan S.;  Ziemann, Paul J.;  Pye, Havala O. T.;  Murphy, Benjamin N.;  Xu, Lu;  Ng, Nga L.;  McKinney, Karena A.;  Budisulistiorini, Sri Hapsari;  Bertram, Timothy H.;  Nenes, Athanasios;  Surratt, Jason D.
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
biogenic organic aerosol  positive matrix factorization  aerosol mass spectrometer  Fourier transform infrared spectroscopy  NOx  
Discovery of 1Hz Range Modulation of Isolated Proton Aurora at Subauroral Latitudes 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2018, 45 (3) : 1209-1217
作者:  Ozaki, M.;  Shiokawa, K.;  Miyoshi, Y.;  Kataoka, R.;  Connors, M.;  Inoue, T.;  Yagitani, S.;  Ebihara, Y.;  Jun, C. -W.;  Nomura, R.;  Sakaguchi, K.;  Otsuka, Y.;  Uchida, H. A.;  Schofield, I.;  Danskin, D. W.
收藏  |  浏览/下载:14/0  |  提交时间:2019/04/09
isolated proton aurora  Pc1 geomagnetic pulsations  wave-particle interaction  
The Impact of Cross-track Infrared Sounder (CrIS) Cloud-Cleared Radiances on Hurricane Joaquin (2015) and Matthew (2016) Forecasts 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2017, 122 (24)
作者:  Wang, Pei;  Li, Jun;  Li, Zhenglong;  Lim, Agnes H. N.;  Li, Jinlong;  Schmit, Timothy J.;  Goldberg, Mitchell D.
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09
data assimilation  satellite radiance assimilation  cloud-clearing method  regional NWP  hurricane forecast  
Diagenetic silica enrichment and late-stage groundwater activity in Gale crater, Mars 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (10)
作者:  Frydenvang, J.;  Gasda, P. J.;  Hurowitz, J. A.;  Grotzinger, J. P.;  Wiens, R. C.;  Newsom, H. E.;  Edgett, K. S.;  Watkins, J.;  Bridges, J. C.;  Maurice, S.;  Fisk, M. R.;  Johnson, J. R.;  Rapin, W.;  Stein, N. T.;  Clegg, S. M.;  Schwenzer, S. P.;  Bedford, C. C.;  Edwards, P.;  Mangold, N.;  Cousin, A.;  Anderson, R. B.;  Payre, V.;  Vaniman, D.;  Blake, D. F.;  Lanza, N. L.;  Gupta, S.;  Van Beek, J.;  Sautter, V.;  Meslin, P. -Y.;  Rice, M.;  Milliken, R.;  Gellert, R.;  Thompson, L.;  Clark, B. C.;  Sumner, D. Y.;  Fraeman, A. A.;  Kinch, K. M.;  Madsen, M. B.;  Mitrofanov, I. G.;  Jun, I.;  Calef, F.;  Vasavada, A. R.
收藏  |  浏览/下载:13/0  |  提交时间:2019/04/09
Diagenesis  Silica  Groundwater  Gale crater  Mars  MSL