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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Genomic architecture and introgression shape a butterfly radiation 期刊论文
SCIENCE, 2019, 366 (6465) : 594-+
作者:  Edelman, Nathaniel B.;  Frandsen, Paul B.;  Miyagi, Michael;  Clavijo, Bernardo;  Davey, John;  Dikow, Rebecca B.;  Garcia-Accinelli, Gonzalo;  Van Belleghem, Steven M.;  Patterson, Nick;  Neafsey, Daniel E.;  Challis, Richard;  Kumar, Sujai;  Moreira, Gilson R. P.;  Salazar, Camilo;  Chouteau, Mathieu;  Counterman, Brian A.;  Papa, Riccardo;  Blaxter, Mark;  Reed, Robert D.;  Dasmahapatra, Kanchon K.;  Kronforst, Marcus;  Joron, Mathieu;  Jiggins, Chris D.;  McMillan, W. Owen;  Di Palma, Federica;  Blumberg, Andrew J.;  Wakeley, John;  Jaffe, David;  Mallet, James
收藏  |  浏览/下载：10/0  |  提交时间：2020/02/17
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate 期刊论文
SCIENCE, 2019, 363 (6432) : 1217-+
作者:  Chakraborty, Abhishek A.;  Laukka, Tuomas;  Myllykoski, Matti;  Ringel, Alison E.;  Booker, Matthew A.;  Tolstorukov, Michael Y.;  Meng, Yuzhong Jeff;  Meier, Samuel R.;  Jennings, Rebecca B.;  Creech, Amanda L.;  Herbert, Zachary T.;  McBrayer, Samuel K.;  Olenchock, Benjamin A.;  Jaffe, Jacob D.;  Haigis, Marcia C.;  Beroukhim, Rameen;  Signoretti, Sabina;  Koivunen, Peppi;  Kaelin, William G., Jr.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
US particulate matter air quality improves except in wildfire-prone areas 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (31) : 7901-7906
作者:  McClure, Crystal D.;  Jaffe, Daniel A.
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/27
PM2.5  wildfires  particulate matter  Kriging  Quantile Regression  
Impact of Biomass Burning Plumes on Photolysis Rates and Ozone Formation at the Mount Bachelor Observatory 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (4) : 2272-2284
作者:  Baylon, P.;  Jaffe, D. A.;  Hall, S. R.;  Ullmann, K.;  Alvarado, M. J.;  Lefer, B. L.
收藏  |  浏览/下载：5/0  |  提交时间：2019/04/09
Meteorological anomalies lead to elevated O-3 in the western U. S. in June 2015 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (4)
作者:  Jaffe, D. A.;  Zhang, L.
收藏  |  浏览/下载：0/0  |  提交时间：2019/04/09
Impacts of the July 2012 Siberian fire plume on air quality in the Pacific Northwest 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (4)
作者:  Teakles, Andrew D.;  So, Rita;  Ainslie, Bruce;  Nissen, Robert;  Schiller, Corinne;  Vingarzan, Roxanne;  McKendry, Ian;  Macdonald, Anne Marie;  Jaffe, Daniel A.;  Bertram, Allan K.;  Strawbridge, Kevin B.;  Leaitch, W. Richard;  Hanna, Sarah;  Toom, Desiree;  Baik, Jonathan;  Huang, Lin
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09