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Convergent evolution of pain-inducing defensive venom components in spitting cobras 期刊论文
Science, 2021
作者:  T. D. Kazandjian;  D. Petras;  S. D. Robinson;  J. van Thiel;  H. W. Greene;  K. Arbuckle;  A. Barlow;  D. A. Carter;  R. M. Wouters;  G. Whiteley;  S. C. Wagstaff;  A. S. Arias;  L.-O. Albulescu;  A. Plettenberg Laing;  C. Hall;  A. Heap;  S. Penrhyn-Lowe;  C. V. McCabe;  S. Ainsworth;  R. R. da Silva;  P. C. Dorrestein;  M. K. Richardson;  J. M. Gutiérrez;  J. J. Calvete;  R. A. Harrison;  I. Vetter;  E. A. B. Undheim;  W. Wüster;  N. R. Casewell
收藏  |  浏览/下载：12/0  |  提交时间：2021/01/28
Aberrant type 1 immunity drives susceptibility to mucosal fungal infections 期刊论文
Science, 2021
作者:  Timothy J. Break;  Vasileios Oikonomou;  Nicolas Dutzan;  Jigar V. Desai;  Marc Swidergall;  Tilo Freiwald;  Daniel Chauss;  Oliver J. Harrison;  Julie Alejo;  Drake W. Williams;  Stefania Pittaluga;  Chyi-Chia R. Lee;  Nicolas Bouladoux;  Muthulekha Swamydas;  Kevin W. Hoffman;  Teresa Greenwell-Wild;  Vincent M. Bruno;  Lindsey B. Rosen;  Wint Lwin;  Andy Renteria;  Sergio M. Pontejo;  John P. Shannon;  Ian A. Myles;  Peter Olbrich;  Elise M. N. Ferré;  Monica Schmitt;  Daniel Martin;  Genomics and Computational Biology Core16;  Daniel L. Barber;  Norma V. Solis;  Luigi D. Notarangelo;  David V. Serreze;  Mitsuru Matsumoto;  Heather D. Hickman;  Philip M. Murphy;  Mark S. Anderson;  Jean K. Lim;  Steven M. Holland;  Scott G. Filler;  Behdad Afzali;  Yasmine Belkaid;  Niki M. Moutsopoulos;  Michail S. Lionakis
收藏  |  浏览/下载：13/0  |  提交时间：2021/01/22
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth 期刊论文
Science, 2021
作者:  Ryan S. Roark;  Hui Li;  Wilton B. Williams;  Hema Chug;  Rosemarie D. Mason;  Jason Gorman;  Shuyi Wang;  Fang-Hua Lee;  Juliette Rando;  Mattia Bonsignori;  Kwan-Ki Hwang;  Kevin O. Saunders;  Kevin Wiehe;  M. Anthony Moody;  Peter T. Hraber;  Kshitij Wagh;  Elena E. Giorgi;  Ronnie M. Russell;  Frederic Bibollet-Ruche;  Weimin Liu;  Jesse Connell;  Andrew G. Smith;  Julia DeVoto;  Alexander I. Murphy;  Jessica Smith;  Wenge Ding;  Chengyan Zhao;  Neha Chohan;  Maho Okumura;  Christina Rosario;  Yu Ding;  Emily Lindemuth;  Anya M. Bauer;  Katharine J. Bar;  David Ambrozak;  Cara W. Chao;  Gwo-Yu Chuang;  Hui Geng;  Bob C. Lin;  Mark K. Louder;  Richard Nguyen;  Baoshan Zhang;  Mark G. Lewis;  Donald D. Raymond;  Nicole A. Doria-Rose;  Chaim A. Schramm;  Daniel C. Douek;  Mario Roederer;  Thomas B. Kepler;  Garnett Kelsoe;  John R. Mascola;  Peter D. Kwong;  Bette T. Korber;  Stephen C. Harrison;  Barton F. Haynes;  Beatrice H. Hahn;  George M. Shaw
收藏  |  浏览/下载：22/0  |  提交时间：2021/01/15
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Meteorological Source Variability in Atmospheric Gravity Wave Parameters Derived From a Tropical Infrasound Station 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (8) : 4352-4364
作者:  Marlton, G. J.;  Charlton-Perez, A. J.;  Harrison, R. G.;  Blanc, E.;  Evers, L.;  Le-Pichon, A.;  Smets, P. S. M.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/26
Electrical sensing of the dynamical structure of the planetary boundary layer 期刊论文
ATMOSPHERIC RESEARCH, 2018, 202: 81-95
作者:  Nicoll, K. A.;  Harrison, R. G.;  Silva, H. G.;  Salgado, R.;  Melgao, M.;  Bortoli, D.
收藏  |  浏览/下载：0/0  |  提交时间：2019/04/09
Solar-Driven Variation in the Atmosphere of Uranus 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2017, 44 (24)
作者:  Aplin, K. L.;  Harrison, R. G.
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/09
ionization  cosmic rays  aerosol  nucleation  
Illuminating gravitational waves: A concordant picture of photons from a neutron star merger 期刊论文
SCIENCE, 2017, 358 (6370) : 1559-+
作者:  Kasliwal, M. M.;  Nakar, E.;  Singer, L. P.;  Kaplan, D. L.;  Cook, D. O.;  Van Sistine, A.;  Lau, R. M.;  Fremling, C.;  Gottlieb, O.;  Jencson, J. E.;  Adams, S. M.;  Feindt, U.;  Hotokezaka, K.;  Ghosh, S.;  Perley, D. A.;  Yu, P-C.;  Piran, T.;  Allison, J. R.;  Anupama, G. C.;  Balasubramanian, A.;  WBannister, K.;  Bally, J.;  Barnes, J.;  Barway, S.;  Bellm, E.;  Bhalerao, V.;  Bhattacharya, D.;  Blagorodnova, N.;  Bloom, J. S.;  Brady, P. R.;  Cannella, C.;  Chatterjee, D.;  Cenko, S. B.;  Cobb, B. E.;  Copperwheat, C.;  Corsi, A.;  De, K.;  Dobie, D.;  Emery, S. W. K.;  Evans, P. A.;  Fox, O. D.;  Frail, D. A.;  Frohmaier, C.;  Goobar, A.;  Hallinan, G.;  Harrison, F.;  Helou, G.;  Hinderer, T.;  Ho, A. Y. Q.;  Horesh, A.;  Ip, W-H.;  Itoh, R.;  Kasen, D.;  Kim, H.;  Kuin, N. P. M.;  Kupfer, T.;  Lynch, C.;  Madsen, K.;  Mazzali, P. A.;  Miller, A. A.;  Mooley, K.;  Murphy, T.;  Ngeow, C-C.;  Nichols, D.;  Nissanke, S.;  Nugent, P.;  Ofek, E. O.;  Qi, H.;  Quimby, R. M.;  Rosswog, S.;  Rusu, F.;  Sadler, E. M.;  Schmidt, P.;  Sollerman, J.;  Steele, I.;  Williamson, A. R.;  Xu, Y.;  Yan, L.;  Yatsu, Y.;  Zhang, C.;  Zhao, W.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Global warming and recurrent mass bleaching of corals 期刊论文
NATURE, 2017, 543 (7645) : 373-+
作者:  Hughes, Terry P.;  Kerry, James T.;  Alvarez-Noriega, Mariana;  Alvarez-Romero, Jorge G.;  Anderson, Kristen D.;  Baird, Andrew H.;  Babcock, Russell C.;  Beger, Maria;  Bellwood, David R.;  Berkelmans, Ray;  Bridge, Tom C.;  Butler, Ian R.;  Byrne, Maria;  Cantin, Neal E.;  Comeau, Steeve;  Connolly, Sean R.;  Cumming, Graeme S.;  Dalton, Steven J.;  Diaz-Pulido, Guillermo;  Eakin, C. Mark;  Figueira, Will F.;  Gilmour, James P.;  Harrison, Hugo B.;  Heron, Scott F.;  Hoey, Andrew S.;  Hobbs, Jean-Paul A.;  Hoogenboom, Mia O.;  Kennedy, Emma V.;  Kuo, Chao-yang;  Lough, Janice M.;  Lowe, Ryan J.;  Liu, Gang;  Cculloch, Malcolm T. M.;  Malcolm, Hamish A.;  Mcwilliam, Michael J.;  Pandolfi, John M.;  Pears, Rachel J.;  Pratchett, Morgan S.;  Schoepf, Verena;  Simpson, Tristan;  Skirving, William J.;  Sommer, Brigitte;  Torda, Gergely;  Wachenfeld, David R.;  Willis, Bette L.;  Wilson, Shaun K.
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27