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Organizational principles of hyporheic exchange flow and biogeochemical cycling in river networks across scales 期刊论文
Water Resources Research, 2022
作者:  Stefan Krause;  Benjamin W. Abbott;  Viktor Baranov;  Susana Bernal;  Phillip Blaen;  Thibault Datry;  Jennifer Drummond;  Jan H. Fleckenstein;  Jesus Gomez Velez;  David M. Hannah;  Julia L. A. Knapp;  Marie Kurz;  ;  rg Lewandowski;  Eugè;  nia Martí;  Clara Mendoza-Lera;  Alexander Milner;  Aaron Packman;  Gilles Pinay;  Adam S. Ward;  Jay P. Zarnetzke
收藏  |  浏览/下载:14/0  |  提交时间:2022/02/23
Multilayer Network Clarifies Prevailing Water Consumption Telecouplings in the United States 期刊论文
Water Resources Research, 2021
作者:  S. Garcia;  M. Gomez;  R. Rushforth;  B. L. Ruddell;  A. Mejia
收藏  |  浏览/下载:9/0  |  提交时间:2021/07/27
Multipoint Density Measurements of Geocoronal Pickup Ions 期刊论文
Geophysical Research Letters, 2021
作者:  R. G. Gomez;  S. A. Fuselier;  J. M. Sokó;  ł;  J. L. Burch;  D. M. Malaspina;  K. J. Trattner;  C. A. Gonzalez;  J. Mukherjee;  R. J. Strangeway
收藏  |  浏览/下载:15/0  |  提交时间:2021/06/24
Evidence for Non‐adiabatic Oxygen Energization in the near‐Earth Magnetotail from MMS 期刊论文
Geophysical Research Letters, 2020
作者:  S. T. Bingham;  R. Nikoukar;  I. J. Cohen;  B. H. Mauk;  D. L. Turner;  D. G. Mitchell;  J. L. Burch;  R. G. Gomez;  S. A. Fuselier;  R. B. Torbert
收藏  |  浏览/下载:11/0  |  提交时间:2021/01/22
Global CO2 emissions from dry inland waters share common drivers across ecosystems 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Keller, P. S.;  Catalan, N.;  von Schiller, D.;  Grossart, H-P;  Koschorreck, M.;  Obrador, B.;  Frassl, M. A.;  Karakaya, N.;  Barros, N.;  Howitt, J. A.;  Mendoza-Lera, C.;  Pastor, A.;  Flaim, G.;  Aben, R.;  Riis, T.;  Arce, M., I;  Onandia, G.;  Paranaiba, J. R.;  Linkhorst, A.;  del Campo, R.;  Amado, A. M.;  Cauvy-Fraunie, S.;  Brothers, S.;  Condon, J.;  Mendonca, R. F.;  Reverey, F.;  Room, E-, I;  Datry, T.;  Roland, F.;  Laas, A.;  Obertegger, U.;  Park, J-H;  Wang, H.;  Kosten, S.;  Gomez, R.;  Feijoo, C.;  Elosegi, A.;  Sanchez-Montoya, M. M.;  Finlayson, C. M.;  Melita, M.;  Oliveira Junior, E. S.;  Muniz, C. C.;  Gomez-Gener, L.;  Leigh, C.;  Zhang, Q.;  Marce, R.
收藏  |  浏览/下载:14/0  |  提交时间:2020/05/13
Pharmacologic fibroblast reprogramming into photoreceptors restores vision 期刊论文
NATURE, 2020, 581 (7806) : 83-+
作者:  Jiang, Mingkai;  Medlyn, Belinda E.;  Drake, John E.;  Duursma, Remko A.;  Anderson, Ian C.;  Barton, Craig V. M.;  Boer, Matthias M.;  Carrillo, Yolima;  Castaneda-Gomez, Laura;  Collins, Luke;  Crous, Kristine Y.;  De Kauwe, Martin G.;  dos Santos, Bruna M.;  Emmerson, Kathryn M.;  Facey, Sarah L.;  Gherlenda, Andrew N.;  Gimeno, Teresa E.;  Hasegawa, Shun;  Johnson, Scott N.;  Kannaste, Astrid;  Macdonald, Catriona A.;  Mahmud, Kashif;  Moore, Ben D.;  Nazaries, Loic;  Neilson, Elizabeth H. J.;  Nielsen, Uffe N.;  Niinemets, Ulo;  Noh, Nam Jin;  Ochoa-Hueso, Raul;  Pathare, Varsha S.;  Pendall, Elise;  Pihlblad, Johanna;  Pineiro, Juan;  Powell, Jeff R.;  Power, Sally A.;  Reich, Peter B.;  Renchon, Alexandre A.;  Riegler, Markus;  Rinnan, Riikka;  Rymer, Paul D.;  Salomon, Roberto L.;  Singh, Brajesh K.;  Smith, Benjamin;  Tjoelker, Mark G.;  Walker, Jennifer K. M.;  Wujeska-Klause, Agnieszka;  Yang, Jinyan;  Zaehle, Soenke;  Ellsworth, David S.
收藏  |  浏览/下载:45/0  |  提交时间:2020/07/03

Photoreceptor loss is the final common endpoint in most retinopathies that lead to irreversible blindness, and there are no effective treatments to restore vision(1,2). Chemical reprogramming of fibroblasts offers an opportunity to reverse vision loss  however, the generation of sensory neuronal subtypes such as photoreceptors remains a challenge. Here we report that the administration of a set of five small molecules can chemically induce the transformation of fibroblasts into rod photoreceptor-like cells. The transplantation of these chemically induced photoreceptor-like cells (CiPCs) into the subretinal space of rod degeneration mice (homozygous for rd1, also known as Pde6b) leads to partial restoration of the pupil reflex and visual function. We show that mitonuclear communication is a key determining factor for the reprogramming of fibroblasts into CiPCs. Specifically, treatment with these five compounds leads to the translocation of AXIN2 to the mitochondria, which results in the production of reactive oxygen species, the activation of NF-kappa B and the upregulation of Ascl1. We anticipate that CiPCs could have therapeutic potential for restoring vision.


A set of five small molecules can induce the transformation of fibroblasts into rod photoreceptor-like cells, which can partially restore pupil reflex and visual function when transplanted into a rod degeneration mouse model.


  
Jupiter's Gravity Field Halfway Through the Juno Mission 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (4)
作者:  Durante, D.;  Parise, M.;  Serra, D.;  Zannoni, M.;  Notaro, V;  Racioppa, P.;  Buccino, D. R.;  Lari, G.;  Casajus, L. Gomez;  Iess, L.;  Folkner, W. M.;  Tommei, G.;  Tortora, P.;  Bolton, S. J.
收藏  |  浏览/下载:7/0  |  提交时间:2020/07/02
Acceleration of Interstellar Pickup He+ at Earth's Perpendicular Bow Shock 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019
作者:  Starkey, M. J.;  Fuselier, S. A.;  Desai, M., I;  Burch, J. L.;  Gomez, R. G.;  Mukherjee, J.;  Russell, C. T.;  Lai, H.;  Schwartz, S. J.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
pickup ions  shock acceleration  bow shock  
Forecasting species range dynamics with process-explicit models: matching methods to applications 期刊论文
ECOLOGY LETTERS, 2019, 22 (11) : 1940-1956
作者:  Briscoe, Natalie J.;  Elith, Jane;  Salguero-Gomez, Roberto;  Lahoz-Monfort, Jose J.;  Camac, James S.;  Giljohann, Katherine M.;  Holden, Matthew H.;  Hradsky, Bronwyn A.;  Kearney, Michael R.;  McMahon, Sean M.;  Phillips, Ben L.;  Regan, Tracey J.;  Rhodes, Jonathan R.;  Vesk, Peter A.;  Wintle, Brendan A.;  Yen, Jian D. L.;  Guillera-Arroita, Gurutzeta
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Demography  mechanistic  population dynamics  process-based models  species distribution model  
Simulating rewetting events in intermittent rivers and ephemeral streams: A global analysis of leached nutrients and organic matter 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (5) : 1591-1611
作者:  Shumilova, Oleksandra;  Zak, Dominik;  Datry, Thibault;  von Schiller, Daniel;  Corti, Roland;  Foulquier, Arnaud;  Obrador, Biel;  Tockner, Klement;  Allan, Daniel C.;  Altermatt, Florian;  Isabel Arce, Maria;  Arnon, Shai;  Banas, Damien;  Banegas-Medina, Andy;  Beller, Erin;  Blanchette, Melanie L.;  Blanco-Libreros, Juan F.;  Blessing, Joanna;  Boechat, Iola Goncalves;  Boersma, Kate;  Bogan, Michael T.;  Bonada, Nuria;  Bond, Nick R.;  Brintrup, Kate;  Bruder, Andreas;  Burrows, Ryan;  Cancellario, Tommaso;  Carlson, Stephanie M.;  Cauvy-Fraunie, Sophie;  Cid, Nuria;  Danger, Michael;  de Freitas Terra, Bianca;  De Girolamo, Anna Maria;  del Campo, Ruben;  Dyer, Fiona;  Elosegi, Arturo;  Faye, Emile;  Febria, Catherine;  Figueroa, Ricardo;  Four, Brian;  Gessner, Mark O.;  Gnohossou, Pierre;  Cerezo, Rosa Gomez;  Gomez-Gener, Lluis;  Graca, Manuel A. S.;  Guareschi, Simone;  Guecker, Bjoern;  Hwan, Jason L.;  Kubheka, Skhumbuzo;  Langhans, Simone Daniela;  Leigh, Catherine;  Little, Chelsea J.;  Lorenz, Stefan;  Marshall, Jonathan;  McIntosh, Angus;  Mendoza-Lera, Clara;  Meyer, Elisabeth Irmgard;  Milisa, Marko;  Mlambo, Musa C.;  Moleon, Marcos;  Negus, Peter;  Niyogi, Dev;  Papatheodoulou, Athina;  Pardo, Isabel;  Paril, Petr;  Pesic, Vladimir;  Rodriguez-Lozano, Pablo;  Rolls, Robert J.;  Sanchez-Montoya, Maria Mar;  Savic, Ana;  Steward, Alisha;  Stubbington, Rachel;  Taleb, Amina;  Vander Vorste, Ross;  Waltham, Nathan;  Zoppini, Annamaria;  Zarfl, Christiane
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/26
biofilms  leaching  leaf litter  rewetting  sediments  temporary rivers