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Stepwise pathogenic evolution of Mycobacterium abscessus 期刊论文
Science, 2021
作者:  Josephine M. Bryant;  Karen P. Brown;  Sophie Burbaud;  Isobel Everall;  Juan M. Belardinelli;  Daniela Rodriguez-Rincon;  Dorothy M. Grogono;  Chelsea M. Peterson;  Deepshikha Verma;  Ieuan E. Evans;  Christopher Ruis;  Aaron Weimann;  Divya Arora;  Sony Malhotra;  Bridget Bannerman;  Charlotte Passemar;  Kerra Templeton;  Gordon MacGregor;  Kasim Jiwa;  Andrew J. Fisher;  Tom L. Blundell;  Diane J. Ordway;  Mary Jackson;  Julian Parkhill;  R. Andres Floto
收藏  |  浏览/下载：14/0  |  提交时间：2021/05/07
Cobenefits and Regulatory Impact Analysis: Theory and Evidence from Federal Air Quality Regulations 科技报告
来源：Resources for the Future. 出版年： 2021
作者:  Joseph E. Aldy;  Matthew J. Kotchen;  Mary Evans;  Meredith Fowlie;  Arik Levinson;  and Karen Palmer
收藏  |  浏览/下载：9/0  |  提交时间：2021/02/17
Co-Benefits and Regulatory Impact Analysis: Theory and Evidence from Federal Air Quality Regulations 科技报告
来源：Resources for the Future. 出版年： 2020
作者:  Joseph E. Aldy;  Matthew Kotchen;  Mary Evans;  Meredith Fowlie;  Arik Levinson;  and Karen Palmer
收藏  |  浏览/下载：6/0  |  提交时间：2020/08/25
We need a global movement to transform ocean science for a better world 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (18) : 9652-9655
作者:  Pendleton, Linwood;  Evans, Karen;  Visbeck, Martin
收藏  |  浏览/下载：1/0  |  提交时间：2020/05/13
Deep Flaws in a Mercury Regulatory Analysis 科技报告
来源：Resources for the Future. 出版年： 2020
作者:  Joseph E. Aldy;  Matthew Kotchen;  Mary Evans;  Meredith Fowlie;  Arik Levinson;  and Karen Palmer
收藏  |  浏览/下载：5/0  |  提交时间：2020/06/16
Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy 期刊论文
NATURE, 2020, 578 (7794) : 273-+
作者:  Senior, Andrew W.;  Evans, Richard;  Jumper, John;  Kirkpatrick, James;  Sifre, Laurent;  Green, Tim;  Qin, Chongli;  Zidek, Augustin;  Nelson, Alexander W. R.;  Bridgland, Alex;  Penedones, Hugo;  Petersen, Stig;  Simonyan, Karen;  Crossan, Steve;  Kohli, Pushmeet;  Jones, David T.;  Silver, David;  Kavukcuoglu, Koray;  Hassabis, Demis
收藏  |  浏览/下载：40/0  |  提交时间：2020/07/03

Synucleinopathies are neurodegenerative diseases that are associated with the misfolding and aggregation of alpha-synuclein, including Parkinson'  s disease, dementia with Lewy bodies and multiple system atrophy(1). Clinically, it is challenging to differentiate Parkinson'  s disease and multiple system atrophy, especially at the early stages of disease(2). Aggregates of alpha-synuclein in distinct synucleinopathies have been proposed to represent different conformational strains of alpha-synuclein that can self-propagate and spread from cell to cell(3-6). Protein misfolding cyclic amplification (PMCA) is a technique that has previously been used to detect alpha-synuclein aggregates in samples of cerebrospinal fluid with high sensitivity and specificity(7,8). Here we show that the alpha-synuclein-PMCA assay can discriminate between samples of cerebrospinal fluid from patients diagnosed with Parkinson'  s disease and samples from patients with multiple system atrophy, with an overall sensitivity of 95.4%. We used a combination of biochemical, biophysical and biological methods to analyse the product of alpha-synuclein-PMCA, and found that the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid could be used to readily distinguish between Parkinson'  s disease and multiple system atrophy. We also found that the properties of aggregates that were amplified from the cerebrospinal fluid were similar to those of aggregates that were amplified from the brain. These findings suggest that alpha-synuclein aggregates that are associated with Parkinson'  s disease and multiple system atrophy correspond to different conformational strains of alpha-synuclein, which can be amplified and detected by alpha-synuclein-PMCA. Our results may help to improve our understanding of the mechanism of alpha-synuclein misfolding and the structures of the aggregates that are implicated in different synucleinopathies, and may also enable the development of a biochemical assay to discriminate between Parkinson'  s disease and multiple system atrophy.


Protein misfolding cyclic amplification (PMCA) technology can discriminate between patients with Parkinson'  s disease and patients with multiple system atrophy on the basis of the characteristics of the alpha-synuclein aggregates in the cerebrospinal fluid.


  
Pile age age and burn season influence fuelbed properties, combustion dynamics, fuel consumption, and charcoal formation when burning hand piles 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 439: 146-158
作者:  Wright, Clinton S.;  Evans, Alexander M.;  Grove, Sara;  Haubensak, Karen A.
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/26
Charcoal  Dry conifer forest  Flame height  Flaming duration  Fuel treatment  Pile burning