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Characterizing the hygroscopicity of growing particles in the Canadian Arctic summer 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Rachel Y.-W. Chang, Jonathan P. D. Abbatt, Matthew C. Boyer, Jai Prakash Chaubey, and Douglas B. Collins
收藏  |  浏览/下载:10/0  |  提交时间:2022/06/24
Sequence diversity analyses of an improved rhesus macaque genome enhance its biomedical utility 期刊论文
Science, 2020
作者:  Wesley C. Warren;  R. Alan Harris;  Marina Haukness;  Ian T. Fiddes;  Shwetha C. Murali;  Jason Fernandes;  Philip C. Dishuck;  Jessica M. Storer;  Muthuswamy Raveendran;  LaDeana W. Hillier;  David Porubsky;  Yafei Mao;  David Gordon;  Mitchell R. Vollger;  Alexandra P. Lewis;  Katherine M. Munson;  Elizabeth DeVogelaere;  Joel Armstrong;  Mark Diekhans;  Jerilyn A. Walker;  Chad Tomlinson;  Tina A. Graves-Lindsay;  Milinn Kremitzki;  Sofie R. Salama;  Peter A. Audano;  Merly Escalona;  Nicholas W. Maurer;  Francesca Antonacci;  Ludovica Mercuri;  Flavia A. M. Maggiolini;  Claudia Rita Catacchio;  Jason G. Underwood;  David H. O’Connor;  Ashley D. Sanders;  Jan O. Korbel;  Betsy Ferguson;  H. Michael Kubisch;  Louis Picker;  Ned H. Kalin;  Douglas Rosene;  Jon Levine;  David H. Abbott;  Stanton B. Gray;  Mar M. Sanchez;  Zsofia A. Kovacs-Balint;  Joseph W. Kemnitz;  Sara M. Thomasy;  Jeffrey A. Roberts;  Erin L. Kinnally;  John P. Capitanio;  J. H. Pate Skene;  Michael Platt;  Shelley A. Cole;  Richard E. Green;  Mario Ventura;  Roger W. Wiseman;  Benedict Paten;  Mark A. Batzer;  Jeffrey Rogers;  Evan E. Eichler
收藏  |  浏览/下载:19/0  |  提交时间:2020/12/22
Nitrogen cycling microbiomes are structured by plant mycorrhizal associations with consequences for nitrogen oxide fluxes in forests 期刊论文
Global Change Biology, 2020
作者:  Ryan M. Mushinski;  Zachary C. Payne;  Jonathan D. Raff;  Matthew E. Craig;  Sally E. Pusede;  Douglas B. Rusch;  Jeffrey R. White;  Richard P. Phillips
收藏  |  浏览/下载:9/0  |  提交时间:2020/12/22
Parental benefits and offspring costs reflect parent–offspring conflict over the age of fledging among songbirds 期刊论文
Proceedings of the National Academy of Sciences, 2020
作者:  Todd M. Jones;  Jeffrey D. Brawn;  Ian J. Ausprey;  Andrew C. Vitz;  Amanda D. Rodewald;  Douglas W. Raybuck;  Than J. Boves;  Cameron J. Fiss;  Darin J. McNeil;  Scott H. Stoleson;  Jeffery L. Larkin;  W. Andrew Cox;  Amy C. Schwarzer;  Noah P. Horsley;  Evalynn M. Trumbo;  Michael P. Ward
收藏  |  浏览/下载:10/0  |  提交时间:2020/11/24
Low-impact land use pathways to deep decarbonization of electricity 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (7)
作者:  Wu, Grace C.;  Leslie, Emily;  Sawyerr, Oluwafemi;  Cameron, D. Richard;  Brand, Erica;  Cohen, Brian;  Allen, Douglas;  Ochoa, Marcela;  Olson, Arne
收藏  |  浏览/下载:9/0  |  提交时间:2020/08/18
renewable energy  deep decarbonization  land use  conservation  solar energy  wind energy  siting  
Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease 期刊论文
NATURE, 2020, 577 (7790) : 399-+
作者:  Gate, David;  Saligrama, Naresha;  Leventhal, Olivia;  Yang, Andrew C.;  Unger, Michael S.;  Middeldorp, Jinte;  Chen, Kelly;  Lehallier, Benoit;  Channappa, Divya;  De Los Santos, Mark B.;  McBride, Alisha;  Pluvinage, John;  Elahi, Fanny;  Tam, Grace Kyin-Ye;  Kim, Yongha;  Greicius, Michael;  Wagner, Anthony D.;  Aigner, Ludwig;  Galasko, Douglas R.;  Davis, Mark M.;  Wyss-Coray, Tony
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/03

Alzheimer'  s disease is an incurable neurodegenerative disorder in which neuroinflammation has a critical function(1). However, little is known about the contribution of the adaptive immune response in Alzheimer'  s disease(2). Here, using integrated analyses of multiple cohorts, we identify peripheral and central adaptive immune changes in Alzheimer'  s disease. First, we performed mass cytometry of peripheral blood mononuclear cells and discovered an immune signature of Alzheimer'  s disease that consists of increased numbers of CD8(+) T effector memory CD45RA(+) (T-EMRA) cells. In a second cohort, we found that CD8(+) T-EMRA cells were negatively associated with cognition. Furthermore, single-cell RNA sequencing revealed that T cell receptor (TCR) signalling was enhanced in these cells. Notably, by using several strategies of single-cell TCR sequencing in a third cohort, we discovered clonally expanded CD8(+) T-EMRA cells in the cerebrospinal fluid of patients with Alzheimer'  s disease. Finally, we used machine learning, cloning and peptide screens to demonstrate the specificity of clonally expanded TCRs in the cerebrospinal fluid of patients with Alzheimer'  s disease to two separate Epstein-Barr virus antigens. These results reveal an adaptive immune response in the blood and cerebrospinal fluid in Alzheimer'  s disease and provide evidence of clonal, antigen-experienced T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration.


  
Long-term thermal sensitivity of Earth’s tropical forests 期刊论文
Science, 2020
作者:  Martin J. P. Sullivan;  Simon L. Lewis;  Kofi Affum-Baffoe;  Carolina Castilho;  Flávia Costa;  Aida Cuni Sanchez;  Corneille E. N. Ewango;  Wannes Hubau;  Beatriz Marimon;  Abel Monteagudo-Mendoza;  Lan Qie;  Bonaventure Sonké;  Rodolfo Vasquez Martinez;  Timothy R. Baker;  Roel J. W. Brienen;  Ted R. Feldpausch;  David Galbraith;  Manuel Gloor;  Yadvinder Malhi;  Shin-Ichiro Aiba;  Miguel N. Alexiades;  Everton C. Almeida;  Edmar Almeida de Oliveira;  Esteban Álvarez Dávila;  Patricia Alvarez Loayza;  Ana Andrade;  Simone Aparecida Vieira;  Luiz E. O. C. Aragão;  Alejandro Araujo-Murakami;  Eric J. M. M. Arets;  Luzmila Arroyo;  Peter Ashton;  Gerardo Aymard C.;  Fabrício B. Baccaro;  Lindsay F. Banin;  Christopher Baraloto;  Plínio Barbosa Camargo;  Jos Barlow;  Jorcely Barroso;  Jean-François Bastin;  Sarah A. Batterman;  Hans Beeckman;  Serge K. Begne;  Amy C. Bennett;  Erika Berenguer;  Nicholas Berry;  Lilian Blanc;  Pascal Boeckx;  Jan Bogaert;  Damien Bonal;  Frans Bongers;  Matt Bradford;  Francis Q. Brearley;  Terry Brncic;  Foster Brown;  Benoit Burban;  José Luís Camargo;  Wendeson Castro;  Carlos Céron;  Sabina Cerruto Ribeiro;  Victor Chama Moscoso;  Jerôme Chave;  Eric Chezeaux;  Connie J. Clark;  Fernanda Coelho de Souza;  Murray Collins;  James A. Comiskey;  Fernando Cornejo Valverde;  Massiel Corrales Medina;  Lola da Costa;  Martin Dančák;  Greta C. Dargie;  Stuart Davies;  Nallaret Davila Cardozo;  Thales de Haulleville;  Marcelo Brilhante de Medeiros;  Jhon del Aguila Pasquel;  Géraldine Derroire;  Anthony Di Fiore;  Jean-Louis Doucet;  Aurélie Dourdain;  Vincent Droissant;  Luisa Fernanda Duque;  Romeo Ekoungoulou;  Fernando Elias;  Terry Erwin;  Adriane Esquivel-Muelbert;  Sophie Fauset;  Joice Ferreira;  Gerardo Flores Llampazo;  Ernest Foli;  Andrew Ford;  Martin Gilpin;  Jefferson S. Hall;  Keith C. Hamer;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Radim Hédl;  Bruno Herault;  Rafael Herrera;  Niro Higuchi;  Annette Hladik;  Eurídice Honorio Coronado;  Isau Huamantupa-Chuquimaco;  Walter Huaraca Huasco;  Kathryn J. Jeffery;  Eliana Jimenez-Rojas;  Michelle Kalamandeen;  Marie Noël Kamdem Djuikouo;  Elizabeth Kearsley;  Ricardo Keichi Umetsu;  Lip Khoon Kho;  Timothy Killeen;  Kanehiro Kitayama;  Bente Klitgaard;  Alexander Koch;  Nicolas Labrière;  William Laurance;  Susan Laurance;  Miguel E. Leal;  Aurora Levesley;  Adriano J. N. Lima;  Janvier Lisingo;  Aline P. Lopes;  Gabriela Lopez-Gonzalez;  Tom Lovejoy;  Jon C. Lovett;  Richard Lowe;  William E. Magnusson;  Jagoba Malumbres-Olarte;  Ângelo Gilberto Manzatto;  Ben Hur Marimon;  Andrew R. Marshall;  Toby Marthews;  Simone Matias de Almeida Reis;  Colin Maycock;  Karina Melgaço;  Casimiro Mendoza;  Faizah Metali;  Vianet Mihindou;  William Milliken;  Edward T. A. Mitchard;  Paulo S. Morandi;  Hannah L. Mossman;  Laszlo Nagy;  Henrique Nascimento;  David Neill;  Reuben Nilus;  Percy Núñez Vargas;  Walter Palacios;  Nadir Pallqui Camacho;  Julie Peacock;  Colin Pendry;  Maria Cristina Peñuela Mora;  Georgia C. Pickavance;  John Pipoly;  Nigel Pitman;  Maureen Playfair;  Lourens Poorter;  John R. Poulsen;  Axel Dalberg Poulsen;  Richard Preziosi;  Adriana Prieto;  Richard B. Primack;  Hirma Ramírez-Angulo;  Jan Reitsma;  Maxime Réjou-Méchain;  Zorayda Restrepo Correa;  Thaiane Rodrigues de Sousa;  Lily Rodriguez Bayona;  Anand Roopsind;  Agustín Rudas;  Ervan Rutishauser;  Kamariah Abu Salim;  Rafael P. Salomão;  Juliana Schietti;  Douglas Sheil;  Richarlly C. Silva;  Javier Silva Espejo;  Camila Silva Valeria;  Marcos Silveira;  Murielle Simo-Droissart;  Marcelo Fragomeni Simon;  James Singh;  Yahn Carlos Soto Shareva;  Clement Stahl;  Juliana Stropp;  Rahayu Sukri;  Terry Sunderland;  Martin Svátek;  Michael D. Swaine;  Varun Swamy;  Hermann Taedoumg;  Joey Talbot;  James Taplin;  David Taylor;  Hans ter Steege;  John Terborgh;  Raquel Thomas;  Sean C. Thomas;  Armando Torres-Lezama;  Peter Umunay;  Luis Valenzuela Gamarra;  Geertje van der Heijden;  Peter van der Hout;  Peter van der Meer;  Mark van Nieuwstadt;  Hans Verbeeck;  Ronald Vernimmen;  Alberto Vicentini;  Ima Célia Guimarães Vieira;  Emilio Vilanova Torre;  Jason Vleminckx;  Vincent Vos;  Ophelia Wang;  Lee J. T. White;  Simon Willcock;  John T. Woods;  Verginia Wortel;  Kenneth Young;  Roderick Zagt;  Lise Zemagho;  Pieter A. Zuidema;  Joeri A. Zwerts;  Oliver L. Phillips
收藏  |  浏览/下载:28/0  |  提交时间:2020/05/25
Observation of Bose-Einstein condensates in an Earth-orbiting research lab 期刊论文
NATURE, 2020, 582 (7811) : 103-+
作者:  Yamamoto, Keisuke;  Venida, Anthony;  Yano, Julian;  Biancur, Douglas E.;  Kakiuchi, Miwako;  Gupta, Suprit;  Sohn, Albert S. W.;  Mukhopadhyay, Subhadip;  Lin, Elaine Y.;  Parker, Seth J.;  Banh, Robert S.;  Paulo, Joao A.;  Wen, Kwun Wah;  Debnath, Jayanta;  Kim, Grace E.;  Mancias, Joseph D.;  Fearon, Douglas T.;  Perera, Rushika M.;  Kimmelman, Alec C.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Quantum mechanics governs the microscopic world, where low mass and momentum reveal a natural wave-particle duality. Magnifying quantum behaviour to macroscopic scales is a major strength of the technique of cooling and trapping atomic gases, in which low momentum is engineered through extremely low temperatures. Advances in this field have achieved such precise control over atomic systems that gravity, often negligible when considering individual atoms, has emerged as a substantial obstacle. In particular, although weaker trapping fields would allow access to lower temperatures(1,2), gravity empties atom traps that are too weak. Additionally, inertial sensors based on cold atoms could reach better sensitivities if the free-fall time of the atoms after release from the trap could be made longer(3). Planetary orbit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such terrestrial limitations. Here we report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laboratory, the Cold Atom Lab. We observe subnanokelvin BECs in weak trapping potentials with free-expansion times extending beyond one second, providing an initial demonstration of the advantages offered by a microgravity environment for cold-atom experiments and verifying the successful operation of this facility. With routine BEC production, continuing operations will support long-term investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physics(7,8)and pathfinding techniques for atom-wave interferometry(9-12).


  
Characterization of organic aerosol across the global remote troposphere: a comparison of ATom measurements and global chemistry models 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (8) : 4607-4635
作者:  Hodzic, Alma;  Campuzano-Jost, Pedro;  Bian, Huisheng;  Chin, Mian;  Colarco, Peter R.;  Day, Douglas A.;  Froyd, Karl D.;  Heinold, Bernd;  Jo, Duseong S.;  Katich, Joseph M.;  Kodros, John K.;  Nault, Benjamin A.;  Pierce, Jeffrey R.;  Ray, Eric;  Schacht, Jacob;  Schill, Gregory P.;  Schroder, Jason C.;  Schwarz, Joshua P.;  Sueper, Donna T.;  Tegen, Ina;  Tilmes, Simone;  Tsigaridis, Kostas;  Yu, Pengfei;  Jimenez, Jose L.
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/02
Asynchronous carbon sink saturation in African and Amazonian tropical forests 期刊论文
NATURE, 2020, 579 (7797) : 80-+
作者:  Wannes Hubau;  Simon L. Lewis;  Oliver L. Phillips;  Kofi Affum-Baffoe;  Hans Beeckman;  Aida Cuní;  -Sanchez;  Armandu K. Daniels;  Corneille E. N. Ewango;  Sophie Fauset;  Jacques M. Mukinzi;  Douglas Sheil;  Bonaventure Sonké;  Martin J. P. Sullivan;  Terry C. H. Sunderland;  Hermann Taedoumg;  Sean C. Thomas;  Lee J. T. White;  Katharine A. Abernethy;  Stephen Adu-Bredu;  Christian A. Amani;  Timothy R. Baker;  Lindsay F. Banin;  Fidè;  le Baya;  Serge K. Begne;  Amy C. Bennett;  Fabrice Benedet;  Robert Bitariho;  Yannick E. Bocko;  Pascal Boeckx;  Patrick Boundja;  Roel J. W. Brienen;  Terry Brncic;  Eric Chezeaux;  George B. Chuyong;  Connie J. Clark;  Murray Collins;  James A. Comiskey;  David A. Coomes;  Greta C. Dargie;  Thales de Haulleville;  Marie Noel Djuikouo Kamdem;  Jean-Louis Doucet;  Adriane Esquivel-Muelbert;  Ted R. Feldpausch;  Alusine Fofanah;  Ernest G. Foli;  Martin Gilpin;  Emanuel Gloor;  Christelle Gonmadje;  Sylvie Gourlet-Fleury;  Jefferson S. Hall;  Alan C. Hamilton;  David J. Harris;  Terese B. Hart;  Mireille B. N. Hockemba;  Annette Hladik;  Suspense A. Ifo;  Kathryn J. Jeffery;  Tommaso Jucker;  Emmanuel Kasongo Yakusu;  Elizabeth Kearsley;  David Kenfack;  Alexander Koch;  Miguel E. Leal;  Aurora Levesley;  Jeremy A. Lindsell;  Janvier Lisingo;  Gabriela Lopez-Gonzalez;  Jon C. Lovett;  Jean-Remy Makana;  Yadvinder Malhi;  Andrew R. Marshall;  Jim Martin;  Emanuel H. Martin;  Faustin M. Mbayu;  Vincent P. Medjibe;  Vianet Mihindou;  Edward T. A. Mitchard;  Sam Moore;  Pantaleo K. T. Munishi;  Natacha Nssi Bengone;  Lucas Ojo;  Fidè;  le Evouna Ondo;  Kelvin S.-H. Peh;  Georgia C. Pickavance;  Axel Dalberg Poulsen;  John R. Poulsen;  Lan Qie;  Jan Reitsma;  Francesco Rovero;  Michael D. Swaine;  Joey Talbot;  James Taplin;  David M. Taylor;  Duncan W. Thomas;  Benjamin Toirambe;  John Tshibamba Mukendi;  Darlington Tuagben;  Peter M. Umunay;  Geertje M. F. van der Heijden;  Hans Verbeeck;  Jason Vleminckx;  Simon Willcock;  Hannsjö;  rg Wö;  ll;  John T. Woods;  Lise Zemagho
收藏  |  浏览/下载:23/0  |  提交时间:2020/05/13

Structurally intact tropical forests sequestered about half of the global terrestrial carbon uptake over the 1990s and early 2000s, removing about 15 per cent of anthropogenic carbon dioxide emissions(1-3). Climate-driven vegetation models typically predict that this tropical forest '  carbon sink'  will continue for decades(4,5). Here we assess trends in the carbon sink using 244 structurally intact African tropical forests spanning 11 countries, compare them with 321 published plots from Amazonia and investigate the underlying drivers of the trends. The carbon sink in live aboveground biomass in intact African tropical forests has been stable for the three decades to 2015, at 0.66 tonnes of carbon per hectare per year (95 per cent confidence interval 0.53-0.79), in contrast to the long-term decline in Amazonian forests(6). Therefore the carbon sink responses of Earth'  s two largest expanses of tropical forest have diverged. The difference is largely driven by carbon losses from tree mortality, with no detectable multi-decadal trend in Africa and a long-term increase in Amazonia. Both continents show increasing tree growth, consistent with the expected net effect of rising atmospheric carbon dioxide and air temperature(7-9). Despite the past stability of the African carbon sink, our most intensively monitored plots suggest a post-2010 increase in carbon losses, delayed compared to Amazonia, indicating asynchronous carbon sink saturation on the two continents. A statistical model including carbon dioxide, temperature, drought and forest dynamics accounts for the observed trends and indicates a long-term future decline in the African sink, whereas the Amazonian sink continues to weaken rapidly. Overall, the uptake of carbon into Earth'  s intact tropical forests peaked in the 1990s. Given that the global terrestrial carbon sink is increasing in size, independent observations indicating greater recent carbon uptake into the Northern Hemisphere landmass(10) reinforce our conclusion that the intact tropical forest carbon sink has already peaked. This saturation and ongoing decline of the tropical forest carbon sink has consequences for policies intended to stabilize Earth'  s climate.