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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches 期刊论文
SCIENCE, 2019, 363 (6432) : 1190-+
作者:  Chakarov, Svetoslav;  Lim, Hwee Ying;  Tan, Leonard;  Lim, Sheau Yng;  See, Peter;  Lum, Josephine;  Zhang, Xiao-Meng;  Foo, Shihui;  Nakamizo, Satoshi;  Duan, Kaibo;  Kong, Wan Ting;  Gentek, Rebecca;  Balachander, Akhila;  Carbajo, Daniel;  Bleriot, Camille;  Malleret, Benoit;  Tam, John Kit Chung;  Baig, Sonia;  Shabeer, Muhammad;  Toh, Sue-Anne Ee Shiow;  Schlitzer, Andreas;  Larbi, Anis;  Marichal, Thomas;  Malissen, Bernard;  Chen, Jinmiao;  Poidinger, Michael;  Kabashima, Kenji;  Bajenoff, Marc;  Ng, Lai Guan;  Angeli, Veronique;  Ginhoux, Florent
收藏  |  浏览/下载：20/0  |  提交时间：2019/11/27
Stratospheric Injection of Brominated Very Short-Lived Substances: Aircraft Observations in the Western Pacific and Representation in Global Models 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (10) : 5690-5719
作者:  Wales, Pamela A.;  Salawitch, Ross J.;  Nicely, Julie M.;  Anderson, Daniel C.;  Canty, Timothy P.;  Baidar, Sunil;  Dix, Barbara;  Koenig, Theodore K.;  Volkamer, Rainer;  Chen, Dexian;  Huey, L. Gregory;  Tanner, David J.;  Cuevas, Carlos A.;  Fernandez, Rafael P.;  Kinnison, Douglas E.;  Lamarque, Jean-Francois;  Saiz-Lopez, Alfonso;  Atlas, Elliot L.;  Hall, Samuel R.;  Navarro, Maria A.;  Pan, Laura L.;  Schauffler, Sue M.;  Stell, Meghan;  Tilmes, Simone;  Ullmann, Kirk;  Weinheimer, Andrew J.;  Akiyoshi, Hideharu;  Chipperfield, Martyn P.;  Deushi, Makoto;  Dhomse, Sandip S.;  Feng, Wuhu;  Graf, Phoebe;  Hossaini, Ryan;  Joeckel, Patrick;  Mancini, Eva;  Michou, Martine;  Morgenstern, Olaf;  Oman, Luke D.;  Pitari, Giovanni;  Plummer, David A.;  Revell, Laura E.;  Rozanov, Eugene;  Saint-Martin, David;  Schofield, Robyn;  Stenke, Andrea;  Stone, Kane A.;  Visioni, Daniele;  Yamashita, Yousuke;  Zeng, Guang
收藏  |  浏览/下载：16/0  |  提交时间：2019/04/09
bromine  CONTRAST  CCMI  VSLS  
BrO and inferred Br-y profiles over the western Pacific: relevance of inorganic bromine sources and a Br-y minimum in the aged tropical tropopause layer 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (24)
作者:  Koenig, Theodore K.;  Volkamer, Rainer;  Baidar, Sunil;  Dix, Barbara;  Wang, Siyuan;  Anderson, Daniel C.;  Salawitch, Ross J.;  Wales, Pamela A.;  Cuevas, Carlos A.;  Fernandez, Rafael P.;  Saiz-Lopez, Alfonso;  Evans, Mathew J.;  Sherwen, Tomas;  Jacob, Daniel J.;  Schmidt, Johan;  Kinnison, Douglas;  Lamarque, Jean-Francois;  Apel, Eric C.;  Bresch, James C.;  Campos, Teresa;  Flocke, Frank M.;  Hall, Samuel R.;  Honomichl, Shawn B.;  Hornbrook, Rebecca;  Jensen, Jorgen B.;  Lueb, Richard;  Montzka, Denise D.;  Pan, Laura L.;  Reeves, J. Michael;  Schauffler, Sue M.;  Ullmann, Kirk;  Weinheimer, Andrew J.;  Atlas, Elliot L.;  Donets, Valeria;  Navarro, Maria A.;  Riemer, Daniel;  Blake, Nicola J.;  Chen, Dexian;  Huey, L. Gregory;  Tanner, David J.;  Hanisco, Thomas F.;  Wolfe, Glenn M.
收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09
Modeling Interaction of a Tropical Cyclone with Its Cold Wake 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2017, 74 (12)
作者:  Chen, Sue;  Elsberry, Russell L.;  Harr, Patrick A.
收藏  |  浏览/下载：0/0  |  提交时间：2019/04/09