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Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants 期刊论文
Science, 2021
作者:  Lingshu Wang;  Tongqing Zhou;  Yi Zhang;  Eun Sung Yang;  Chaim A. Schramm;  Wei Shi;  Amarendra Pegu;  Olamide K. Oloniniyi;  Amy R. Henry;  Samuel Darko;  Sandeep R. Narpala;  Christian Hatcher;  David R. Martinez;  Yaroslav Tsybovsky;  Emily Phung;  Olubukola M. Abiona;  Avan Antia;  Evan M. Cale;  Lauren A. Chang;  Misook Choe;  Kizzmekia S. Corbett;  Rachel L. Davis;  Anthony T. DiPiazza;  Ingelise J. Gordon;  Sabrina Helmold Hait;  Tandile Hermanus;  Prudence Kgagudi;  Farida Laboune;  Kwanyee Leung;  Tracy Liu;  Rosemarie D. Mason;  Alexandra F. Nazzari;  Laura Novik;  Sarah O’Connell;  Sijy O’Dell;  Adam S. Olia;  Stephen D. Schmidt;  Tyler Stephens;  Christopher D. Stringham;  Chloe Adrienna Talana;  I-Ting Teng;  Danielle A. Wagner;  Alicia T. Widge;  Baoshan Zhang;  Mario Roederer;  Julie E. Ledgerwood;  Tracy J. Ruckwardt;  Martin R. Gaudinski;  Penny L. Moore;  Nicole A. Doria-Rose;  Ralph S. Baric;  Barney S. Graham;  Adrian B. McDermott;  Daniel C. Douek;  Peter D. Kwong;  John R. Mascola;  Nancy J. Sullivan;  John Misasi
收藏  |  浏览/下载:21/0  |  提交时间:2021/08/17
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling 期刊论文
Science, 2021
作者:  Evan W. Weber;  Kevin R. Parker;  Elena Sotillo;  Rachel C. Lynn;  Hima Anbunathan;  John Lattin;  Zinaida Good;  Julia A. Belk;  Bence Daniel;  Dorota Klysz;  Meena Malipatlolla;  Peng Xu;  Malek Bashti;  Sabine Heitzeneder;  Louai Labanieh;  Panayiotis Vandris;  Robbie G. Majzner;  Yanyan Qi;  Katalin Sandor;  Ling-Chun Chen;  Snehit Prabhu;  Andrew J. Gentles;  Thomas J. Wandless;  Ansuman T. Satpathy;  Howard Y. Chang;  Crystal L. Mackall
收藏  |  浏览/下载:16/0  |  提交时间:2021/04/06
Global reconstruction reduces the uncertainty of oceanic nitrous oxide emissions and reveals a vigorous seasonal cycle 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (22) : 11954-11960
作者:  Yang, Simon;  Chang, Bonnie X.;  Warner, Mark J.;  Weber, Thomas S.;  Bourbonnais, Annie M.;  Santoro, Alyson E.;  Kock, Annette;  Sonnerup, Rolf E.;  Bullister, John L.;  Wilson, Samuel T.;  Bianchi, Daniele
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/20
nitrous oxide  air-sea gas exchange  seasonal variability  nitrogen cycle  greenhouse gases  
Highly porous nature of a primitive asteroid revealed by thermal imaging 期刊论文
NATURE, 2020, 579 (7800) : 518-522
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:47/0  |  提交时间:2020/05/13

Carbonaceous (C-type) asteroids(1) are relics of the early Solar System that have preserved primitive materials since their formation approximately 4.6 billion years ago. They are probably analogues of carbonaceous chondrites(2,3) and are essential for understanding planetary formation processes. However, their physical properties remain poorly known because carbonaceous chondrite meteoroids tend not to survive entry to Earth'  s atmosphere. Here we report on global one-rotation thermographic images of the C-type asteroid 162173 Ryugu, taken by the thermal infrared imager (TIR)(4) onboard the spacecraft Hayabusa2(5), indicating that the asteroid'  s boulders and their surroundings have similar temperatures, with a derived thermal inertia of about 300 J m(-2) s(-0.5) K-1 (300 tiu). Contrary to predictions that the surface consists of regolith and dense boulders, this low thermal inertia suggests that the boulders are more porous than typical carbonaceous chondrites(6) and that their surroundings are covered with porous fragments more than 10 centimetres in diameter. Close-up thermal images confirm the presence of such porous fragments and the flat diurnal temperature profiles suggest a strong surface roughness effect(7,8). We also observed in the close-up thermal images boulders that are colder during the day, with thermal inertia exceeding 600 tiu, corresponding to dense boulders similar to typical carbonaceous chondrites(6). These results constrain the formation history of Ryugu: the asteroid must be a rubble pile formed from impact fragments of a parent body with microporosity(9) of approximately 30 to 50 per cent that experienced a low degree of consolidation. The dense boulders might have originated from the consolidated innermost region or they may have an exogenic origin. This high-porosity asteroid may link cosmic fluffy dust to dense celestial bodies(10).


Thermal imaging data obtained from the spacecraft Hayabusa2 reveal that the carbonaceous asteroid 162173 Ryugu is an object of unusually high porosity.


  
Experimental demonstration of memory-enhanced quantum communication 期刊论文
NATURE, 2020
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/03

The ability to communicate quantum information over long distances is of central importance in quantum science and engineering(1). Although some applications of quantum communication such as secure quantum key distribution(2,3) are already being successfully deployed(4-7), their range is currently limited by photon losses and cannot be extended using straightforward measure-and-repeat strategies without compromising unconditional security(8). Alternatively, quantum repeaters(9), which utilize intermediate quantum memory nodes and error correction techniques, can extend the range of quantum channels. However, their implementation remains an outstanding challenge(10-16), requiring a combination of efficient and high-fidelity quantum memories, gate operations, and measurements. Here we use a single solid-state spin memory integrated in a nanophotonic diamond resonator(17-19) to implement asynchronous photonic Bell-state measurements, which are a key component of quantum repeaters. In a proof-of-principle experiment, we demonstrate high-fidelity operation that effectively enables quantum communication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz clock speeds. These results represent a crucial step towards practical quantum repeaters and large-scale quantum networks(20,21).


A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.


  
Mechanical regulation of glycolysis via cytoskeleton architecture 期刊论文
NATURE, 2020, 578 (7796) : 621-+
作者:  Faivre, Emily J.;  McDaniel, Keith F.;  Albert, Daniel H.;  Mantena, Srinivasa R.;  Plotnik, Joshua P.;  Wilcox, Denise;  Zhang, Lu;  Bui, Mai H.;  Sheppard, George S.;  Wang, Le;  Sehgal, Vasudha;  Lin, Xiaoyu;  Huang, Xiaoli;  Lu, Xin;  Uziel, Tamar;  Hessler, Paul;  Lam, Lloyd T.;  Bellin, Richard J.;  Mehta, Gaurav;  Fidanze, Steve;  Pratt, John K.;  Liu, Dachun;  Hasvold, Lisa A.;  Sun, Chaohong;  Panchal, Sanjay C.;  Nicolette, John J.;  Fossey, Stacey L.;  Park, Chang H.;  Longenecker, Kenton;  Bigelow, Lance;  Torrent, Maricel;  Rosenberg, Saul H.;  Kati, Warren M.;  Shen, Yu
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility(1-3). Although all of these processes consume energy(4,5), it is unknown whether and how cells adapt their metabolic activity to variable mechanical cues. Here we report that the transfer of human bronchial epithelial cells from stiff to soft substrates causes a downregulation of glycolysis via proteasomal degradation of the rate-limiting metabolic enzyme phosphofructokinase (PFK). PFK degradation is triggered by the disassembly of stress fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TRIM21). Transformed non-small-cell lung cancer cells, which maintain high glycolytic rates regardless of changing environmental mechanics, retain PFK expression by downregulating TRIM21, and by sequestering residual TRIM21 on a stress-fibre subset that is insensitive to substrate stiffness. Our data reveal a mechanism by which glycolysis responds to architectural features of the actomyosin cytoskeleton, thus coupling cell metabolism to the mechanical properties of the surrounding tissue. These processes enable normal cells to tune energy production in variable microenvironments, whereas the resistance of the cytoskeleton in response to mechanical cues enables the persistence of high glycolytic rates in cancer cells despite constant alterations of the tumour tissue.


Glycolysis in normal epithelial cells responds to microenvironmental mechanics via the modulation of actin bundles that sequester the phosphofructokinase-targeting ubiquitin ligase TRIM21, a process superseded by persistent actin bundles in cancer cells.


  
A proof of concept for structure-based vaccine design targeting RSV in humans 期刊论文
SCIENCE, 2019, 365 (6452) : 505-+
作者:  Crank, Michelle C.;  Ruckwardt, Tracy J.;  Chen, Man;  Morabito, Kaitlyn M.;  Phung, Emily;  Costner, Pamela J.;  Holman, LaSonji A.;  Hickman, Somia P.;  Berkowitz, Nina M.;  Gordon, Ingelise J.;  Yamshchikov, Galina V.;  Gaudinski, Martin R.;  Kumar, Azad;  Chang, Lauren A.;  Moin, Syed M.;  Hill, Juliane P.;  DiPiazza, Anthony T.;  Schwartz, Richard M.;  Kueltzo, Lisa;  Cooper, Jonathan W.;  Chen, Peifeng;  Stein, Judith A.;  Carlton, Kevin;  Gall, Jason G.;  Nason, Martha C.;  Kwong, Peter D.;  Chen, Grace L.;  Mascola, John R.;  McLellan, Jason S.;  Ledgerwood, Julie E.;  Graham, Barney S.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Carbon dioxide sources from Alaska driven by increasing early winter respiration from Arctic tundra 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (21) : 5361-5366
作者:  Commane, Roisin;  Lindaas, Jakob;  Benmergui, Joshua;  Luus, Kristina A.;  Chang, Rachel Y. -W.;  Daube, Bruce C.;  Euskirchen, Eugenie S.;  Henderson, John M.;  Karion, Anna;  Miller, John B.;  Miller, Scot M.;  Parazoo, Nicholas C.;  Randerson, James T.;  Sweeney, Colm;  Tans, Pieter;  Thoning, Kirk;  Veraverbeke, Sander;  Miller, Charles E.;  Wofsy, Steven C.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
carbon dioxide  Arctic  early winter respiration  Alaska  tundra  
Aging increases cell-to-cell transcriptional variability upon immune stimulation 期刊论文
SCIENCE, 2017, 355 (6332) : 1433-+
作者:  Martinez-Jimenez, Celia Pilar;  Eling, Nils;  Chen, Hung-Chang;  Vallejos, Catalina A.;  Kolodziejczyk, Aleksandra A.;  Connor, Frances;  Stojic, Lovorka;  Rayner, Timothy F.;  Stubbington, Michael J. T.;  Teichmann, Sarah A.;  de la Roche, Maike;  Marioni, John C.;  Odom, Duncan T.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27