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Annual cycle observations of aerosols capable of ice formation in central Arctic clouds 期刊论文
Nature Communications, 2022
作者:  Creamean, Jessie M.;  Barry, Kevin;  Hill, Thomas C. J.;  Hume, Carson;  DeMott, Paul J.;  Shupe, Matthew D.;  Dahlke, Sandro;  Willmes, Sascha;  Schmale, Julia;  Beck, Ivo;  Hoppe, Clara J. M.;  Fong, Allison;  Chamberlain, Emelia;  Bowman, Jeff;  Scharien, Randall;  Persson, Ola
收藏  |  浏览/下载:15/0  |  提交时间:2022/06/24
The biogeographic differentiation of algal microbiomes in the upper ocean from pole to pole 期刊论文
Nature Communications, 2021
作者:  Martin, Kara;  Schmidt, Katrin;  Toseland, Andrew;  Boulton, Chris A.;  Barry, Kerrie;  Beszteri, Bá;  nk;  Brussaard, Corina P. D.;  Clum, Alicia;  Daum, Chris G.;  Eloe-Fadrosh, Emiley;  Fong, Allison;  Foster, Brian;  Foster, Bryce;  Ginzburg, Michael;  Huntemann, Marcel;  Ivanova, Natalia N.;  Kyrpides, Nikos C.;  Lindquist, Erika;  Mukherjee, Supratim;  Palaniappan, Krishnaveni;  Reddy, T. B. K.;  Rizkallah, Mariam R.;  Roux, Simon;  Timmermans, Klaas;  Tringe, Susannah G.;  van de Poll, Willem H.;  Varghese, Neha;  Valentin, Klaus U.;  Lenton, Timothy M.;  Grigoriev, Igor V.;  Leggett, Richard M.;  Moulton, Vincent;  Mock, Thomas
收藏  |  浏览/下载:17/0  |  提交时间:2021/10/07
Summer warmth of the past six interglacials on Greenland 期刊论文
Proceedings of the National Academy of Science, 2021
作者:  Allison A. Cluett;  Elizabeth K. Thomas
收藏  |  浏览/下载:10/0  |  提交时间:2021/05/21
The biophysical climate mitigation potential of boreal peatlands during the growing season 期刊论文
Environmental Research Letters, 2020
作者:  Manuel Helbig;  James M Waddington;  Pavel Alekseychik;  Brian Amiro;  Mika Aurela;  Alan G Barr;  T Andrew Black;  Sean K Carey;  Jiquan Chen;  Jinshu Chi;  Ankur R Desai;  Allison Dunn;  Eugenie S Euskirchen;  Lawrence B Flanagan;  Thomas Friborg;  Michelle Garneau;  Achim Grelle;  Silvie Harder;  Michal Heliasz;  Elyn R Humphreys;  Hiroki Ikawa;  Pierre-Erik Isabelle;  Hiroki Iwata;  Rachhpal Jassal;  Mika Korkiakoski;  Juliya Kurbatova;  Lars Kutzbach;  Elena Lapshina;  Anders Lindroth;  Mikaell Ottosson Löfvenius;  Annalea Lohila;  Ivan Mammarella;  Philip Marsh;  Paul A Moore;  Trofim Maximov;  Daniel F Nadeau;  Erin M Nicholls;  Mats B Nilsson;  Takeshi Ohta;  Matthias Peichl;  Richard M Petrone;  Anatoly Prokushkin;  William L Quinton;  Nigel Roulet;  Benjamin R K Runkle;  Oliver Sonnentag;  Ian B Strachan;  Pierre Taillardat;  Eeva-Stiina Tuittila;  Juha-Pekka Tuovinen;  Jessica Turner;  Masahito Ueyama;  Andrej Varlagin;  Timo Vesala;  Martin Wilmking;  Vyacheslav Zyrianov;  Christopher Schulze
收藏  |  浏览/下载:24/0  |  提交时间:2020/10/20
Rate of mass loss from the Greenland Ice Sheet will exceed Holocene values this century 期刊论文
Nature, 2020
作者:  Jason P. Briner;  Joshua K. Cuzzone;  Jessica A. Badgeley;  Nicolá;  s E. Young;  Eric J. Steig;  Mathieu Morlighem;  Nicole-Jeanne Schlegel;  Gregory J. Hakim;  Joerg M. Schaefer;  Jesse V. Johnson;  Alia J. Lesnek;  Elizabeth K. Thomas;  Estelle Allan;  Ole Bennike;  Allison A. Cluett;  Beata Csatho;  Anne de Vernal;  Jacob Downs;  Eric Larour;  Sophie Nowicki
收藏  |  浏览/下载:10/0  |  提交时间:2020/10/12
The structure of human CST reveals a decameric assembly bound to telomeric DNA 期刊论文
Science, 2020
作者:  Ci Ji Lim;  Alexandra T. Barbour;  Arthur J. Zaug;  Karen J. Goodrich;  Allison E. McKay;  Deborah S. Wuttke;  Thomas R. Cech
收藏  |  浏览/下载:5/0  |  提交时间:2020/06/09
Increasing contribution of peatlands to boreal evapotranspiration in a warming climate 期刊论文
NATURE CLIMATE CHANGE, 2020, 10 (6) : 555-+
作者:  Helbig, Manuel;  Waddington, James Michael;  Alekseychik, Pavel;  Amiro, Brian D.;  Aurela, Mika;  Barr, Alan G.;  Black, T. Andrew;  Blanken, Peter D.;  Carey, Sean K.;  Chen, Jiquan;  Chi, Jinshu;  Desai, Ankur R.;  Dunn, Allison;  Euskirchen, Eugenie S.;  Flanagan, Lawrence B.;  Forbrich, Inke;  Friborg, Thomas;  Grelle, Achim;  Harder, Silvie;  Heliasz, Michal;  Humphreys, Elyn R.;  Ikawa, Hiroki;  Isabelle, Pierre-Erik;  Iwata, Hiroki;  Jassal, Rachhpal;  Korkiakoski, Mika;  Kurbatova, Juliya;  Kutzbach, Lars;  Lindroth, Anders;  Lofvenius, Mikaell Ottosson;  Lohila, Annalea;  Mammarella, Ivan;  Marsh, Philip;  Maximov, Trofim;  Melton, Joe R.;  Moore, Paul A.;  Nadeau, Daniel F.;  Nicholls, Erin M.;  Nilsson, Mats B.;  Ohta, Takeshi;  Peichl, Matthias;  Petrone, Richard M.;  Petrov, Roman;  Prokushkin, Anatoly;  Quinton, William L.;  Reed, David E.;  Roulet, Nigel T.;  Runkle, Benjamin R. K.;  Sonnentag, Oliver;  Strachan, Ian B.;  Taillardat, Pierre;  Tuittila, Eeva-Stiina;  Tuovinen, Juha-Pekka;  Turner, Jessica;  Ueyama, Masahito;  Varlagin, Andrej;  Wilmking, Martin;  Wofsy, Steven C.;  Zyrianov, Vyacheslav
收藏  |  浏览/下载:17/0  |  提交时间:2020/05/13
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:40/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition 期刊论文
SCIENCE, 2019, 363 (6426) : 498-+
作者:  Ballinger, Elaine;  Mosior, John;  Hartman, Travis;  Burns-Huang, Kristin;  Gold, Ben;  Morris, Roxanne;  Goullieux, Laurent;  Blanc, Isabelle;  Vaubourgeix, Julien;  Lagrange, Sophie;  Fraisse, Laurent;  Sans, Stephanie;  Couturier, Cedric;  Bacque, Eric;  Rhee, Kyu;  Scarry, Sarah M.;  Aube, Jeffrey;  Yang, Guangbin;  Ouerfelli, Ouathek;  Schnappinger, Dirk;  Ioerger, Thomas R.;  Engelhart, Curtis A.;  McConnell, Jennifer A.;  McAulay, Kathrine;  Fay, Allison;  Roubert, Christine;  Sacchettini, James;  Nathan, Carl
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Simulations of Vertical Water Vapor Transport for TC Ingrid (2013) 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2018, 123 (15) : 8255-8282
作者:  Allison, Thomas;  Fuelberg, Henry;  Heath, Nicholas
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
tropical cyclones  water vapor  transport