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Fine particle characterization in a coastal city in China: composition, sources, and impacts of industrial emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (5) : 2877-2890
作者:  Lei, Lu;  Xie, Conghui;  Wang, Dawei;  He, Yao;  Wang, Qingqing;  Zhou, Wei;  Hu, Wei;  Fu, Pingqing;  Chen, Yong;  Pan, Xiaole;  Wang, Zifa;  Worsnop, Douglas;  Sun, Yele
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
Mutational signature in colorectal cancer caused by genotoxic pks(+)E. coli 期刊论文
NATURE, 2020, 580 (7802) : 269-+
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu;  Guo, Shimeng;  Han, Gye-Won;  Li, Shaobai;  Yue, Yang;  Wei, Xiaohu;  Xie, Xin;  Chen, Yong;  Zhao, Suwen;  Wu, Jian;  Lei, Ming;  Xu, Fei
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes that synthesize colibactin(3). This compound is believed to alkylate DNA on adenine residues(4,5) and induces double-strand breaks in cultured cells(3). Here we expose human intestinal organoids to genotoxic pks(+)E. coli by repeated luminal injection over five months. Whole-genome sequencing of clonal organoids before and after this exposure revealed a distinct mutational signature that was absent from organoids injected with isogenic pks-mutant bacteria. The same mutational signature was detected in a subset of 5,876 human cancer genomes from two independent cohorts, predominantly in colorectal cancer. Our study describes a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.


Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks(+) island develop a distinct mutational signature associated with colorectal cancer.


  
A High-Resolution Simulation of Roll Convection Over the Yellow Sea During a Cold Air Outbreak 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Chen, Yong;  Yuan, Huiling;  Gao, Shanhong
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
roll convection  cloud street  cold air outbreak  planetary boundary layer  Obukhov length  
China fortifies its marine conservation 期刊论文
NATURE, 2019, 573 (7774) : 346-346
作者:  Li, Yunzhou;  Ren, Yiping;  Chen, Yong
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Vertical observations of the atmospheric boundary layer structure over Beijing urban area during air pollution episodes 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (10) : 6949-6967
作者:  Wang, Linlin;  Liu, Junkai;  Gao, Zhiqiu;  Li, Yubin;  Huang, Meng;  Fan, Sihui;  Zhang, Xiaoye;  Yang, Yuanjian;  Miao, Shiguang;  Zou, Han;  Sun, Yele;  Chen, Yong;  Yang, Ting
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/26
单个烃类包裹体组分及成熟度紫外拉曼光谱定量表征 项目
项目编号:41873070; 经费:680000(CNY); 起止日期:2019 / dc_date_end
项目负责人:  陈勇
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/27
新型人工震源在资源探查的潜在应用 项目
项目编号:41842042; 经费:300000(CNY); 起止日期:2019 / dc_date_end
项目负责人:  陈颙
收藏  |  浏览/下载:2/0  |  提交时间:2019/11/27
典型沙漠化逆转区的生态承载力与脆弱性评价 项目
项目编号:41601587; 经费:220000(CNY); 起止日期:2017 / dc_date_end
项目负责人:  陈勇
收藏  |  浏览/下载:2/0  |  提交时间:2019/04/11
新型绿色人工震源探测(中浅部)地壳结构的研究 项目
项目编号:41674058; 经费:1180000(CNY); 起止日期:2017 / dc_date_end
项目负责人:  陈顒
收藏  |  浏览/下载:2/0  |  提交时间:2019/04/11
塔里木盆地沙尘辐射反馈对天气、沙尘浓度及沉降量的影响研究 项目
项目编号:41505091; 经费:210000(CNY); 起止日期:2016 / dc_date_end
项目负责人:  陈勇
收藏  |  浏览/下载:1/0  |  提交时间:2019/04/11