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Disentangling dynamical and thermodynamical contributions to the record-breaking heatwave over Central Europe in June 2019 期刊论文
Atmospheric Research, 2020
作者:  Peiqiang Xu, Lin Wang, Ping Huang, Wen Chen
收藏  |  浏览/下载:13/0  |  提交时间:2021/01/15
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Abandonment lead to structural degradation and changes in carbon allocation patterns in Moso bamboo forests 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 449
作者:  Yin, Jiayang;  Ge, Zhipeng;  Deng, Xu;  Shi, Yongjun;  Xu, Lin;  Zhou, Guomo;  Ye, Yuzhu;  Zhang, Fagen;  Zhou, Yufeng;  Li, Chong;  Niu, Zhengwen
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Phyllostachys pubescens  Structure degradation  Carbon allocation pattern  Abandoned bamboo forests  
基于自协方差最小二乘的组合自适应抗差Kalman滤波方法研究 项目
项目编号:41801389; 经费:250000(CNY); 起止日期:2019 / dc_date_end
项目负责人:  林旭
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
Quantifying driving factors of vegetation carbon stocks of Moso bamboo forests using machine learning algorithm combined with structural equation model 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 429: 406-413
作者:  Shi, Yongjun;  Xu, Lin;  Zhou, Yufeng;  Ji, Biyong;  Zhou, Guomo;  Fang, Huiyun;  Yin, Jiayang;  Deng, Xu
收藏  |  浏览/下载:8/0  |  提交时间:2019/04/09
Vegetation carbon stocks  Carbon sequestration  Driving factors  Machine learning method  Structural equation modeling  Phyllostachys pubescens  
Dirac-source field-effect transistors as energy-efficient, high-performance electronic switches 期刊论文
SCIENCE, 2018, 361 (6400) : 387-391
作者:  Qiu, Chenguang;  Liu, Fei;  Xu, Lin;  Deng, Bing;  Xiao, Mengmeng;  Si, Jia;  Lin, Li;  Zhang, Zhiyong;  Wang, Jian;  Guo, Hong;  Peng, Hailin;  Peng, Lian-Mao
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Structural development and carbon dynamics of Moso bamboo forests in Zhejiang Province, China 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2018, 409: 479-488
作者:  Xu, Lin;  Shi, Yongjun;  Zhou, Guomo;  Xu, Xiaojun;  Liu, Enbing;  Zhou, Yufeng;  Zhang, Feng;  Li, Chong;  Fang, Huiyun;  Chen, Liang
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/09
Carbon dynamics  Structural development  Carbon sequestration  Aboveground carbon stock  Phyllostachys pubescent  
青海南山新生代隆升与黄河龙羊峡下切时间的低温热年代学研究 项目
项目编号:41702178; 经费:250000(CNY); 起止日期:2018 / dc_date_end
项目负责人:  林旭
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
中国北方自然植物春季物候模拟研究 项目
项目编号:41401048; 经费:260000(CNY); 起止日期:2015 / dc_date_end
项目负责人:  徐琳
收藏  |  浏览/下载:2/0  |  提交时间:2019/04/11