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Regional impacts of black carbon morphologies on shortwave aerosol–radiation interactions: a comparative study between the US and China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Jie Luo, Zhengqiang Li, Chenchong Zhang, Qixing Zhang, Yongming Zhang, Ying Zhang, Gabriele Curci, and Rajan K. Chakrabarty
收藏  |  浏览/下载：14/0  |  提交时间：2022/06/24
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).


  
Assessing Noah-MP Parameterization Sensitivity and Uncertainty Interval Across Snow Climates 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (4)
作者:  You, Yuanhong;  Huang, Chunlin;  Yang, Zongliang;  Zhang, Ying;  Bai, Yulong;  Gu, Juan
收藏  |  浏览/下载：5/0  |  提交时间：2020/07/02
Reply to Comment by Peng and Bi on "Retrieval of Atmospheric Fine Particulate Density Based on Merging Particle Size Distribution Measurements: Multi-instrument Observation and Quality Control at Shouxian" 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (2)
作者:  Li, Zhengqiang;  Wei, Yuanyuan;  Zhang, Ying
收藏  |  浏览/下载：10/0  |  提交时间：2020/07/02
Role of SST feedback in the prediction of the boreal summer monsoon intraseasonal oscillation 期刊论文
CLIMATE DYNAMICS, 2019, 53: 3861-3875
作者:  Zhang, Ying;  Hung, Meng-Pai;  Wang, Wanqiu;  Kumar, Arun
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Interannual to Decadal Variability of Upper-Ocean Salinity in the Southern Indian Ocean and the Role of the Indonesian Throughflow 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (19) : 6403-6421
作者:  Hu, Shijian;  Zhang, Ying;  Feng, Ming;  Du, Yan;  Sprintall, Janet;  Wang, Fan;  Hu, Dunxin;  Xie, Qiang;  Chai, Fei
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27
Indian Ocean  Advection  Atmosphere-ocean interaction  ENSO  Ocean circulation  Thermocline  
Constraining the Large-Scale Analysis of a Regional Rapid-Update-Cycle System for Short-Term Convective Precipitation Forecasting 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (13) : 6949-6965
作者:  Tang, Xiaowen;  Sun, Juanzhen;  Zhang, Ying;  Tong, Wenxue
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/27
The Fundamental Aerosol Models Over China Region: A Cluster Analysis of the Ground-Based Remote Sensing Measurements of Total Columnar Atmosphere 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (9) : 4924-4932
作者:  Li, Zhengqiang;  Zhang, Ying;  Xu, Hua;  Li, Kaitao;  Dubovik, Oleg;  Goloub, Philippe
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/26
Copulas-based risk analysis for inter-seasonal combinations of wet and dry conditions under a changing climate 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (4) : 2005-2021
作者:  Fang, Wei;  Huang, Shengzhi;  Huang, Guohe;  Huang, Qiang;  Wang, Hao;  Wang, Lu;  Zhang, Ying;  Li, Pei;  Ma, Lan
收藏  |  浏览/下载：11/0  |  提交时间：2019/11/26
climate change  copula-based framework  dryness-wetness combination  dynamic risk  joint return period  
Crustal Structure in Alaska From Receiver Function Analysis 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (3) : 1284-1292
作者:  Zhang, Ying;  Li, Aibing;  Hui, Hao
收藏  |  浏览/下载：4/0  |  提交时间：2019/11/26