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Coherent Interannual Variations of Springtime Surface Temperature and Temperature Extremes Between Central-Northern Europe and Northeast Asia 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (11)
作者:  Chen, Shangfeng;  Wu, Renguang;  Chen, Wen;  Yao, Shuailei;  Yu, Bin
收藏  |  浏览/下载:11/0  |  提交时间:2020/08/18
spring temperature  coherent variation  central-northern Europe and Northeast Asia  atmospheric teleconnection  synoptic-scale eddy forcing  North Atlantic SST forcing  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Influence of winter Arctic sea ice concentration change on the El Nino-Southern Oscillation in the following winter 期刊论文
CLIMATE DYNAMICS, 2019
作者:  Chen, Shangfeng;  Wu, Renguang;  Chen, Wen;  Yu, Bin
收藏  |  浏览/下载:8/0  |  提交时间:2020/02/17
Arctic sea ice  ENSO  Atmospheric wave train  Westerly winds  
Interannual variations of the rainy season withdrawal of the monsoon transitional zone in China 期刊论文
CLIMATE DYNAMICS, 2019, 53: 2031-2046
作者:  Zhao, Wei;  Chen, Shangfeng;  Chen, Wen;  Yao, Shuailei;  Nath, Debashis;  Yu, Bin
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Monsoon transitional zone  Withdrawal of rainy season  Northern tropical Atlantic SST  WNP anticyclone  Eurasian atmospheric teleconnection  
Modification of the wintertime Pacific-North American pattern related North American climate anomalies by the Asian-Bering-North American teleconnection 期刊论文
CLIMATE DYNAMICS, 2019, 53: 313-328
作者:  Yu, Bin;  Lin, Hai
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/26
海冰中六水合碳酸钙的形成对海冰碳循环和磷酸盐移除作用的研究 项目
项目编号:41806094; 经费:240000(CNY); 起止日期:2019 / dc_date_end
项目负责人:  胡玉斌
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27
The Asian-Bering-North American teleconnection: seasonality, maintenance, and climate impact on North America 期刊论文
CLIMATE DYNAMICS, 2018, 50: 2023-2038
作者:  Yu, Bin;  Lin, H.;  Wu, Z. W.;  Merryfield, W. J.
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
对流层中高层非绝热加热对我国近海热带气旋突然增强影响的机理研究 项目
项目编号:41775048; 经费:680000(CNY); 起止日期:2018 / dc_date_end
项目负责人:  于玉斌
收藏  |  浏览/下载:0/0  |  提交时间:2019/11/27
The influence of boreal spring Arctic Oscillation on the subsequent winter ENSO in CMIP5 models 期刊论文
CLIMATE DYNAMICS, 2017, 48
作者:  Chen, Shangfeng;  Chen, Wen;  Yu, Bin
收藏  |  浏览/下载:1/0  |  提交时间:2019/04/09
AO  ENSO  CMIP5  Synoptic-scale eddy