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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Receptor modelling of both particle composition and size distribution from a background site in London, UK - a two-step approach 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (7) : 4863-4876
作者:  Beddows, David C. S.;  Harrison, Roy M.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/26
Aliphatic carbonyl compounds (C-8-C-26) in wintertime atmospheric aerosol in London, UK 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (4) : 2233-2246
作者:  Lyu, Ruihe;  Alam, Mohammed S.;  Stark, Christopher;  Xu, Ruixin;  Shi, Zongbo;  Feng, Yinchang;  Harrison, Roy M.
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09
Interpretation of particle number size distributions measured across an urban area during the FASTER campaign 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (1) : 39-55
作者:  Harrison, Roy M.;  Beddows, David C. S.;  Alam, Mohammed S.;  Singh, Ajit;  Brean, James;  Xu, Ruixin;  Kotthaus, Simone;  Grimmond, Sue
收藏  |  浏览/下载：24/0  |  提交时间：2019/04/09
Secondary magnetite in ancient zircon precludes analysis of a Hadean geodynamo 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (2) : 407-412
作者:  Tang, Fengzai;  Taylor, Richard J. M.;  Einsle, Josh F.;  Borlina, Caue S.;  Fu, Roger R.;  Weiss, Benjamin P.;  Williams, Helen M.;  Williams, Wyn;  Nagy, Lesleis;  Midgley, Paul A.;  Lima, Eduardo A.;  Bell, Elizabeth A.;  Harrison, T. Mark;  Alexander, Ellen W.;  Harrison, Richard J.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Hadean  paleomagnetism  Jack Hills  zircon  correlative microscopy  
Vertical and horizontal distribution of regional new particle formation events in Madrid 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (22) : 16601-16618
作者:  Carnerero, Cristina;  Perez, Noemi;  Reche, Cristina;  Ealo, Marina;  Titos, Gloria;  Lee, Hong-Ku;  Eun, Hee-Ram;  Park, Yong-Hee;  Dada, Lubna;  Paasonen, Pauli;  Kerminen, Veli-Matti;  Mantilla, Enrique;  Escudero, Miguel;  Gomez-Moreno, Francisco J.;  Alonso-Blanco, Elisabeth;  Coz, Esther;  Saiz-Lopez, Alfonso;  Temime-Roussel, Brice;  Marchand, Nicolas;  Beddows, David C. S.;  Harrison, Roy M.;  Petaja, Tuukka;  Kulmala, Markku;  Ahn, Kang-Ho;  Alastuey, Andres;  Querol, Xavier
收藏  |  浏览/下载：8/0  |  提交时间：2019/04/09
Technical note: Use of an atmospheric simulation chamber to investigate the effect of different engine conditions on unregulated VOC-IVOC diesel exhaust emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (15) : 11073-11096
作者:  Pereira, Kelly L.;  Dunmore, Rachel;  Whitehead, James;  Alfarra, M. Rami;  Allan, James D.;  Alam, Mohammed S.;  Harrison, Roy M.;  McFiggans, Gordon;  Hamilton, Jacqueline F.
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
Spatial and temporal patterns of mass bleaching of corals in the Anthropocene 期刊论文
SCIENCE, 2018, 359 (6371) : 80-+
作者:  Hughes, Terry P.;  Anderson, Kristen D.;  Connolly, Sean R.;  Heron, Scott F.;  Kerry, James T.;  Lough, Janice M.;  Baird, Andrew H.;  Baum, Julia K.;  Berumen, Michael L.;  Bridge, Tom C.;  Claar, Danielle C.;  Eakin, C. Mark;  Gilmour, James P.;  Graham, Nicholas A. J.;  Harrison, Hugo;  Hobbs, Jean-Paul A.;  Hoey, Andrew S.;  Hoogenboom, Mia;  Lowe, Ryan J.;  McCulloch, Malcolm T.;  Pandolfi, John M.;  Pratchett, Morgan;  Schoepf, Verena;  Torda, Gergely;  Wilson, Shaun K.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Illuminating gravitational waves: A concordant picture of photons from a neutron star merger 期刊论文
SCIENCE, 2017, 358 (6370) : 1559-+
作者:  Kasliwal, M. M.;  Nakar, E.;  Singer, L. P.;  Kaplan, D. L.;  Cook, D. O.;  Van Sistine, A.;  Lau, R. M.;  Fremling, C.;  Gottlieb, O.;  Jencson, J. E.;  Adams, S. M.;  Feindt, U.;  Hotokezaka, K.;  Ghosh, S.;  Perley, D. A.;  Yu, P-C.;  Piran, T.;  Allison, J. R.;  Anupama, G. C.;  Balasubramanian, A.;  WBannister, K.;  Bally, J.;  Barnes, J.;  Barway, S.;  Bellm, E.;  Bhalerao, V.;  Bhattacharya, D.;  Blagorodnova, N.;  Bloom, J. S.;  Brady, P. R.;  Cannella, C.;  Chatterjee, D.;  Cenko, S. B.;  Cobb, B. E.;  Copperwheat, C.;  Corsi, A.;  De, K.;  Dobie, D.;  Emery, S. W. K.;  Evans, P. A.;  Fox, O. D.;  Frail, D. A.;  Frohmaier, C.;  Goobar, A.;  Hallinan, G.;  Harrison, F.;  Helou, G.;  Hinderer, T.;  Ho, A. Y. Q.;  Horesh, A.;  Ip, W-H.;  Itoh, R.;  Kasen, D.;  Kim, H.;  Kuin, N. P. M.;  Kupfer, T.;  Lynch, C.;  Madsen, K.;  Mazzali, P. A.;  Miller, A. A.;  Mooley, K.;  Murphy, T.;  Ngeow, C-C.;  Nichols, D.;  Nissanke, S.;  Nugent, P.;  Ofek, E. O.;  Qi, H.;  Quimby, R. M.;  Rosswog, S.;  Rusu, F.;  Sadler, E. M.;  Schmidt, P.;  Sollerman, J.;  Steele, I.;  Williamson, A. R.;  Xu, Y.;  Yan, L.;  Yatsu, Y.;  Zhang, C.;  Zhao, W.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Sources of sub-micrometre particles near a major international airport 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2017, 17 (20)
作者:  Masiol, Mauro;  Harrison, Roy M.;  Vu, Tuan V.;  Beddows, David C. S.
收藏  |  浏览/下载：6/0  |  提交时间：2019/04/09