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A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Tao Su;  Robert A. Spicer;  Fei-Xiang Wu;  Alexander Farnsworth;  Jian Huang;  Cédric Del Rio;  Tao Deng;  Lin Ding;  Wei-Yu-Dong Deng;  Yong-Jiang Huang;  Alice Hughes;  Lin-Bo Jia;  Jian-Hua Jin;  Shu-Feng Li;  Shui-Qing Liang;  Jia Liu;  Xiao-Yan Liu;  Sarah Sherlock;  Teresa Spicer;  Gaurav Srivastava;  He Tang;  Paul Valdes;  Teng-Xiang Wang;  Mike Widdowson;  Meng-Xiao Wu;  Yao-Wu Xing;  Cong-Li Xu;  Jian Yang;  Cong Zhang;  Shi-Tao Zhang;  Xin-Wen Zhang;  Fan Zhao;  Zhe-Kun Zhou
收藏  |  浏览/下载:11/0  |  提交时间:2020/12/22
Sources of nitrous acid (HONO) in the upper boundary layer and lower free troposphere of North China Plain: insights from the Mount Tai Observatory 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Ying Jiang, Likun Xue, Rongrong Gu, Mengwei Jia, Yingnan Zhang, Liang Wen, Penggang Zheng, Tianshu Chen, Hongyong Li, Ye Shan, Yong Zhao, Zhaoxin Guo, Yujian Bi, Hengde Liu, Aijun Ding, Qingzhu Zhang, and Wenxing Wang
收藏  |  浏览/下载:11/0  |  提交时间:2020/06/01
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Estimating global surface ammonia concentrations inferred from satellite retrievals 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (18) : 12051-12066
作者:  Liu, Lei;  Zhang, Xiuying;  Wong, Anthony Y. H.;  Xu, Wen;  Liu, Xuejun;  Li, Yi;  Mi, Huan;  Lu, Xuehe;  Zhao, Limin;  Wang, Zhen;  Wu, Xiaodi;  Wei, Jing
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Device-independent quantum random-number generation 期刊论文
NATURE, 2018, 562 (7728) : 548-+
作者:  Liu, Yang;  Zhao, Qi;  Li, Ming-Han;  Guan, Jian-Yu;  Zhang, Yanbao;  Bai, Bing;  Zhang, Weijun;  Liu, Wen-Zhao;  Wu, Cheng;  Yuan, Xiao;  Li, Hao;  Munro, W. J.;  Wang, Zhen;  You, Lixing;  Zhang, Jun;  Ma, Xiongfeng;  Fan, Jingyun;  Zhang, Qiang;  Pan, Jian-Wei
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits 期刊论文
SCIENCE, 2019, 364 (6446) : 1152-+
作者:  Chen, Lei;  Qin, Qiang;  Jiang, Yu;  Wang, Kun;  Lin, Zeshan;  Li, Zhipeng;  Bibi, Faysal;  Yang, Yongzhi;  Wang, Jinhuan;  Nie, Wenhui;  Su, Weiting;  Liu, Guichun;  Li, Qiye;  Fu, Weiwei;  Pan, Xiangyu;  Liu, Chang;  Yang, Jie;  Zhang, Chenzhou;  Yin, Yuan;  Wang, Yu;  Zhao, Yue;  Zhang, Chen;  Wang, Zhongkai;  Qin, Yanli;  Liu, Wei;  Wang, Bao;  Ren, Yandong;  Zhang, Ru;  Zeng, Yan;  da Fonseca, Rute R.;  Wei, Bin;  Li, Ran;  Wan, Wenting;  Zhao, Ruoping;  Zhu, Wenbo;  Wang, Yutao;  Duan, Shengchang;  Gao, Yun;  Zhang, Yong E.;  Chen, Chunyan;  Hvilsom, Christina;  Epps, Clinton W.;  Chemnick, Leona G.;  Doug, Yang;  Mirarab, Siavash;  Siegismund, Hans Redlef;  Ryder, Oliver A.;  Gilbert, M. Thomas P.;  Lewin, Harris A.;  Zhang, Guojie;  Heller, Rasmus;  Wang, Wen
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
Genetic basis of ruminant headgear and rapid antler regeneration 期刊论文
SCIENCE, 2019, 364 (6446) : 1153-+
作者:  Wang, Yu;  Zhang, Chenzhou;  Wang, Nini;  Li, Zhipeng;  Heller, Rasmus;  Liu, Rong;  Zhao, Yue;  Han, Jiangang;  Pan, Xiangyu;  Zheng, Zhuqing;  Dai, Xueqin;  Chen, Ceshi;  Dou, Mingle;  Peng, Shujun;  Chen, Xianqing;  Liu, Jing;  Li, Ming;  Wang, Kun;  Liu, Chang;  Lin, Zeshan;  Chen, Lei;  Hao, Fei;  Zhu, Wenbo;  Song, Chengchuang;  Zhao, Chen;  Zheng, Chengli;  Wang, Jianming;  Hu, Shengwei;  Li, Cunyuan;  Yang, Hui;  Jiang, Lin;  Li, Guangyu;  Liu, Mingjun;  Sonstegard, Tad S.;  Zhang, Guojie;  Jiang, Yu;  Wang, Wen;  Qiu, Qiang
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Modeling study on three-dimensional distribution of dust aerosols during a dust storm over the Tarim Basin, Northwest China 期刊论文
ATMOSPHERIC RESEARCH, 2019, 218: 285-295
作者:  Meng, Lu;  Yang, Xinghua;  Zhao, Tianliang;  He, Qing;  Lu, Hui;  Mamtimin, Ali;  Huo, Wen;  Yang, Fan;  Liu, Chong
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
Tarim Basin  WRF-Chem  Dust aerosols  Taldamalcan Desert  Dust storm  
Spatial-temporal patterns of inorganic nitrogen air concentrations and deposition in eastern China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (15) : 10931-10954
作者:  Xu, Wen;  Liu, Lei;  Cheng, Miaomiao;  Zhao, Yuanhong;  Zhang, Lin;  Pan, Yuepeng;  Zhang, Xiuming;  Gu, Baojing;  Li, Yi;  Zhang, Xiuying;  Shen, Jianlin;  Lu, Li;  Luo, Xiaosheng;  Zhao, Yu;  Feng, Zhaozhong;  Collett, Jeffrey L., Jr.;  Zhang, Fusuo;  Liu, Xuejun
收藏  |  浏览/下载:11/0  |  提交时间:2019/04/09