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Strong anthropogenic control of secondary organic aerosol formation from isoprene in Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7531-7552
作者:  Bryant, Daniel J.;  Dixon, William J.;  Hopkins, James R.;  Dunmore, Rachel E.;  Pereira, Kelly;  Shaw, Marvin;  Squires, Freya A.;  Bannan, Thomas J.;  Mehra, Archit;  Worrall, Stephen D.;  Bacak, Asan;  Coe, Hugh;  Percival, Carl J.;  Whalley, Lisa K.;  Heard, Dwayne E.;  Slater, Eloise J.;  Ouyang, Bin;  Cui, Tianqu;  Surratt, Jason D.;  Liu, Di;  Shi, Zongbo;  Harrison, Roy;  Sun, Yele;  Xu, Weiqi;  Lewis, Alastair C.;  Lee, James D.;  Rickard, Andrew R.;  Hamilton, Jacqueline F.
收藏  |  浏览/下载:15/0  |  提交时间:2020/08/18
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载:35/0  |  提交时间:2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
The ice-nucleating ability of quartz immersed in water and its atmospheric importance compared to K-feldspar 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (17) : 11343-11361
作者:  Harrison, Alexander D.;  Lever, Katherine;  Sanchez-Marroquin, Alberto;  Holden, Mark A.;  Whale, Thomas F.;  Tarn, Mark D.;  McQuaid, James B.;  Murray, Benjamin J.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Secondary magnetite in ancient zircon precludes analysis of a Hadean geodynamo 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (2) : 407-412
作者:  Tang, Fengzai;  Taylor, Richard J. M.;  Einsle, Josh F.;  Borlina, Caue S.;  Fu, Roger R.;  Weiss, Benjamin P.;  Williams, Helen M.;  Williams, Wyn;  Nagy, Lesleis;  Midgley, Paul A.;  Lima, Eduardo A.;  Bell, Elizabeth A.;  Harrison, T. Mark;  Alexander, Ellen W.;  Harrison, Richard J.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Hadean  paleomagnetism  Jack Hills  zircon  correlative microscopy  
Technical note: Use of an atmospheric simulation chamber to investigate the effect of different engine conditions on unregulated VOC-IVOC diesel exhaust emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (15) : 11073-11096
作者:  Pereira, Kelly L.;  Dunmore, Rachel;  Whitehead, James;  Alfarra, M. Rami;  Allan, James D.;  Alam, Mohammed S.;  Harrison, Roy M.;  McFiggans, Gordon;  Hamilton, Jacqueline F.
收藏  |  浏览/下载:7/0  |  提交时间:2019/04/09
Spatial and temporal patterns of mass bleaching of corals in the Anthropocene 期刊论文
SCIENCE, 2018, 359 (6371) : 80-+
作者:  Hughes, Terry P.;  Anderson, Kristen D.;  Connolly, Sean R.;  Heron, Scott F.;  Kerry, James T.;  Lough, Janice M.;  Baird, Andrew H.;  Baum, Julia K.;  Berumen, Michael L.;  Bridge, Tom C.;  Claar, Danielle C.;  Eakin, C. Mark;  Gilmour, James P.;  Graham, Nicholas A. J.;  Harrison, Hugo;  Hobbs, Jean-Paul A.;  Hoey, Andrew S.;  Hoogenboom, Mia;  Lowe, Ryan J.;  McCulloch, Malcolm T.;  Pandolfi, John M.;  Pratchett, Morgan;  Schoepf, Verena;  Torda, Gergely;  Wilson, Shaun K.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Illuminating gravitational waves: A concordant picture of photons from a neutron star merger 期刊论文
SCIENCE, 2017, 358 (6370) : 1559-+
作者:  Kasliwal, M. M.;  Nakar, E.;  Singer, L. P.;  Kaplan, D. L.;  Cook, D. O.;  Van Sistine, A.;  Lau, R. M.;  Fremling, C.;  Gottlieb, O.;  Jencson, J. E.;  Adams, S. M.;  Feindt, U.;  Hotokezaka, K.;  Ghosh, S.;  Perley, D. A.;  Yu, P-C.;  Piran, T.;  Allison, J. R.;  Anupama, G. C.;  Balasubramanian, A.;  WBannister, K.;  Bally, J.;  Barnes, J.;  Barway, S.;  Bellm, E.;  Bhalerao, V.;  Bhattacharya, D.;  Blagorodnova, N.;  Bloom, J. S.;  Brady, P. R.;  Cannella, C.;  Chatterjee, D.;  Cenko, S. B.;  Cobb, B. E.;  Copperwheat, C.;  Corsi, A.;  De, K.;  Dobie, D.;  Emery, S. W. K.;  Evans, P. A.;  Fox, O. D.;  Frail, D. A.;  Frohmaier, C.;  Goobar, A.;  Hallinan, G.;  Harrison, F.;  Helou, G.;  Hinderer, T.;  Ho, A. Y. Q.;  Horesh, A.;  Ip, W-H.;  Itoh, R.;  Kasen, D.;  Kim, H.;  Kuin, N. P. M.;  Kupfer, T.;  Lynch, C.;  Madsen, K.;  Mazzali, P. A.;  Miller, A. A.;  Mooley, K.;  Murphy, T.;  Ngeow, C-C.;  Nichols, D.;  Nissanke, S.;  Nugent, P.;  Ofek, E. O.;  Qi, H.;  Quimby, R. M.;  Rosswog, S.;  Rusu, F.;  Sadler, E. M.;  Schmidt, P.;  Sollerman, J.;  Steele, I.;  Williamson, A. R.;  Xu, Y.;  Yan, L.;  Yatsu, Y.;  Zhang, C.;  Zhao, W.
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Global warming and recurrent mass bleaching of corals 期刊论文
NATURE, 2017, 543 (7645) : 373-+
作者:  Hughes, Terry P.;  Kerry, James T.;  Alvarez-Noriega, Mariana;  Alvarez-Romero, Jorge G.;  Anderson, Kristen D.;  Baird, Andrew H.;  Babcock, Russell C.;  Beger, Maria;  Bellwood, David R.;  Berkelmans, Ray;  Bridge, Tom C.;  Butler, Ian R.;  Byrne, Maria;  Cantin, Neal E.;  Comeau, Steeve;  Connolly, Sean R.;  Cumming, Graeme S.;  Dalton, Steven J.;  Diaz-Pulido, Guillermo;  Eakin, C. Mark;  Figueira, Will F.;  Gilmour, James P.;  Harrison, Hugo B.;  Heron, Scott F.;  Hoey, Andrew S.;  Hobbs, Jean-Paul A.;  Hoogenboom, Mia O.;  Kennedy, Emma V.;  Kuo, Chao-yang;  Lough, Janice M.;  Lowe, Ryan J.;  Liu, Gang;  Cculloch, Malcolm T. M.;  Malcolm, Hamish A.;  Mcwilliam, Michael J.;  Pandolfi, John M.;  Pears, Rachel J.;  Pratchett, Morgan S.;  Schoepf, Verena;  Simpson, Tristan;  Skirving, William J.;  Sommer, Brigitte;  Torda, Gergely;  Wachenfeld, David R.;  Willis, Bette L.;  Wilson, Shaun K.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Satellite observations of stratospheric hydrogen fluoride andcomparisons with SLIMCAT calculations 期刊论文
Atmospheric Chemistry and Physics, 2016
作者:  Jeremy J. Harrison, Martyn P. Chipperfield, Christopher D. Boone, Sandip S. Dhomse, Peter F. Bernath, Lucien Froidevaux, John Anderson, and James Russell III
收藏  |  浏览/下载:8/0  |  提交时间:2020/08/18
ACE-FTS observations of acetonitrile in the lower stratosphere 期刊论文
Atmospheric Chemistry and Physics, 2013
作者:  J. J. Harrison and P. F. Bernath
收藏  |  浏览/下载:6/0  |  提交时间:2020/08/18