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CAN THE WORLD MAKE ENOUGH CORONAVIRUS VACCINE? 期刊论文
NATURE, 2020, 580 (7805) : 578-580
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Liu, Mingjie;  Jiang, Lei
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


Researchers warn production constraints and hoarding could limit SARS-CoV-2 vaccine supplies.


  
Very regular high-frequency pulsation modes in young intermediate-mass stars 期刊论文
NATURE, 2020, 581 (7807) : 147-+
作者:  Zhao, Chuangqi;  Zhang, Pengchao;  Zhou, Jiajia;  Qi, Shuanhu;  Yamauchi, Yoshihiro;  Shi, Ruirui;  Fang, Ruochen;  Ishida, Yasuhiro;  Wang, Shutao;  Tomsia, Antoni P.;  Jiang, Lei;  Liu, Mingjie
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Asteroseismology probes the internal structures of stars by using their natural pulsation frequencies(1). It relies on identifying sequences of pulsation modes that can be compared with theoretical models, which has been done successfully for many classes of pulsators, including low-mass solar-type stars(2), red giants(3), high-mass stars(4) and white dwarfs(5). However, a large group of pulsating stars of intermediate mass-the so-called delta Scuti stars-have rich pulsation spectra for which systematic mode identification has not hitherto been possible(6,7). This arises because only a seemingly random subset of possible modes are excited and because rapid rotation tends to spoil regular patterns(8-10). Here we report the detection of remarkably regular sequences of high-frequency pulsation modes in 60 intermediate-mass main-sequence stars, which enables definitive mode identification. The space motions of some of these stars indicate that they are members of known associations of young stars, as confirmed by modelling of their pulsation spectra.


The pulsation spectra of intermediate-mass stars (so-called delta Scuti stars) have been challenging to analyse, but new observations of 60 such stars reveal remarkably regular sequences of high-frequency pulsation modes.


  
Mutational signature in colorectal cancer caused by genotoxic pks(+)E. coli 期刊论文
NATURE, 2020, 580 (7802) : 269-+
作者:  Lin, Xi;  Li, Mingyue;  Wang, Niandong;  Wu, Yiran;  Luo, Zhipu;  Guo, Shimeng;  Han, Gye-Won;  Li, Shaobai;  Yue, Yang;  Wei, Xiaohu;  Xie, Xin;  Chen, Yong;  Zhao, Suwen;  Wu, Jian;  Lei, Ming;  Xu, Fei
收藏  |  浏览/下载:22/0  |  提交时间:2020/07/03

Various species of the intestinal microbiota have been associated with the development of colorectal cancer(1,2), but it has not been demonstrated that bacteria have a direct role in the occurrence of oncogenic mutations. Escherichia coli can carry the pathogenicity island pks, which encodes a set of enzymes that synthesize colibactin(3). This compound is believed to alkylate DNA on adenine residues(4,5) and induces double-strand breaks in cultured cells(3). Here we expose human intestinal organoids to genotoxic pks(+)E. coli by repeated luminal injection over five months. Whole-genome sequencing of clonal organoids before and after this exposure revealed a distinct mutational signature that was absent from organoids injected with isogenic pks-mutant bacteria. The same mutational signature was detected in a subset of 5,876 human cancer genomes from two independent cohorts, predominantly in colorectal cancer. Our study describes a distinct mutational signature in colorectal cancer and implies that the underlying mutational process results directly from past exposure to bacteria carrying the colibactin-producing pks pathogenicity island.


Organoids derived from human intestinal cells that are co-cultured with bacteria carrying the genotoxic pks(+) island develop a distinct mutational signature associated with colorectal cancer.


  
CRISPR-mediated live imaging of genome editing and transcription 期刊论文
SCIENCE, 2019, 365 (6459) : 1301-+
作者:  Wang, Haifeng;  Nakamura, Muneaki;  Abbott, Timothy R.;  Zhao, Dehua;  Luo, Kaiwen;  Yu, Cordelia;  Nguyen, Cindy M.;  Lo, Albert;  Daley, Timothy P.;  La Russa, Marie;  Liu, Yanxia;  Qi, Lei S.
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27
Ice nucleation by aerosols from anthropogenic pollution 期刊论文
NATURE GEOSCIENCE, 2019, 12 (8) : 602-+
作者:  Zhao, Bin;  Wang, Yuan;  Gu, Yu;  Liou, Kuo-Nan;  Jiang, Jonathan H.;  Fan, Jiwen;  Liu, Xiaohong;  Huang, Lei;  Yung, Yuk L.
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits 期刊论文
SCIENCE, 2019, 364 (6446) : 1152-+
作者:  Chen, Lei;  Qin, Qiang;  Jiang, Yu;  Wang, Kun;  Lin, Zeshan;  Li, Zhipeng;  Bibi, Faysal;  Yang, Yongzhi;  Wang, Jinhuan;  Nie, Wenhui;  Su, Weiting;  Liu, Guichun;  Li, Qiye;  Fu, Weiwei;  Pan, Xiangyu;  Liu, Chang;  Yang, Jie;  Zhang, Chenzhou;  Yin, Yuan;  Wang, Yu;  Zhao, Yue;  Zhang, Chen;  Wang, Zhongkai;  Qin, Yanli;  Liu, Wei;  Wang, Bao;  Ren, Yandong;  Zhang, Ru;  Zeng, Yan;  da Fonseca, Rute R.;  Wei, Bin;  Li, Ran;  Wan, Wenting;  Zhao, Ruoping;  Zhu, Wenbo;  Wang, Yutao;  Duan, Shengchang;  Gao, Yun;  Zhang, Yong E.;  Chen, Chunyan;  Hvilsom, Christina;  Epps, Clinton W.;  Chemnick, Leona G.;  Doug, Yang;  Mirarab, Siavash;  Siegismund, Hans Redlef;  Ryder, Oliver A.;  Gilbert, M. Thomas P.;  Lewin, Harris A.;  Zhang, Guojie;  Heller, Rasmus;  Wang, Wen
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
Genetic basis of ruminant headgear and rapid antler regeneration 期刊论文
SCIENCE, 2019, 364 (6446) : 1153-+
作者:  Wang, Yu;  Zhang, Chenzhou;  Wang, Nini;  Li, Zhipeng;  Heller, Rasmus;  Liu, Rong;  Zhao, Yue;  Han, Jiangang;  Pan, Xiangyu;  Zheng, Zhuqing;  Dai, Xueqin;  Chen, Ceshi;  Dou, Mingle;  Peng, Shujun;  Chen, Xianqing;  Liu, Jing;  Li, Ming;  Wang, Kun;  Liu, Chang;  Lin, Zeshan;  Chen, Lei;  Hao, Fei;  Zhu, Wenbo;  Song, Chengchuang;  Zhao, Chen;  Zheng, Chengli;  Wang, Jianming;  Hu, Shengwei;  Li, Cunyuan;  Yang, Hui;  Jiang, Lin;  Li, Guangyu;  Liu, Mingjun;  Sonstegard, Tad S.;  Zhang, Guojie;  Jiang, Yu;  Wang, Wen;  Qiu, Qiang
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Anti-parity-time symmetry in diffusive systems 期刊论文
SCIENCE, 2019, 364 (6436) : 170-+
作者:  Li, Ying;  Peng, Yu-Gui;  Han, Lei;  Miri, Mohammad-Ali;  Li, Wei;  Xiao, Meng;  Zhu, Xue-Feng;  Zhao, Jianlin;  Alu, Andrea;  Fan, Shanhui;  Qiu, Cheng-Wei
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Double-negative-index ceramic aerogels for thermal superinsulation 期刊论文
SCIENCE, 2019, 363 (6428) : 723-+
作者:  Xu, Xiang;  Zhang, Qiangqiang;  Hao, Menglong;  Hu, Yuan;  Lin, Zhaoyang;  Peng, Lele;  Wang, Tao;  Ren, Xuexin;  Wang, Chen;  Zhao, Zipeng;  Wan, Chengzhang;  Fei, Huilong;  Wang, Lei;  Zhu, Jian;  Sun, Hongtao;  Chen, Wenli;  Du, Tao;  Deng, Biwei;  Cheng, Gary J.;  Shakir, Imran;  Dames, Chris;  Fisher, Timothy S.;  Zhang, Xiang;  Li, Hui;  Huang, Yu;  Duan, Xiangfeng
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Inland water bodies in China: Features discovered in the long-term satellite data 期刊论文
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (51) : 25491-25496
作者:  Shuailong Feng;  Shuguang Liu;  Zhihong Huang;  Lei Jing;  Meifang Zhao;  Xi Peng;  Wende Yan;  Yiping Wu;  Yihe Lv;  Andrew R. Smith;  Morag A. McDonald;  Sopan D. Patil;  Arbi J. Sarkissian;  Zhihua Shi;  Jun Xia;  and U. S. Ogbodo
收藏  |  浏览/下载:22/0  |  提交时间:2020/04/16
inland water bodies  size-abundance  land use change  climate change