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Isolated boron in zeolite for oxidative dehydrogenation of propane 期刊论文
Science, 2021
作者:  Hang Zhou;  Xianfeng Yi;  Yu Hui;  Liang Wang;  Wei Chen;  Yucai Qin;  Ming Wang;  Jiabi Ma;  Xuefeng Chu;  Yeqing Wang;  Xin Hong;  Zifeng Chen;  Xiangju Meng;  Hai Wang;  Qiuyan Zhu;  Lijuan Song;  Anmin Zheng;  Feng-Shou Xiao
收藏  |  浏览/下载:15/0  |  提交时间:2021/04/06
Physiological determinants of biogeography: The importance of metabolic depression to heat tolerance 期刊论文
Global Change Biology, 2021
作者:  Ming‐;  ling Liao;  Gao‐;  yang Li;  Jie Wang;  David J. Marshall;  Tin Yan Hui;  Shu‐;  yang Ma;  Yi‐;  min Zhang;  Brian Helmuth;  Yun‐;  wei Dong
收藏  |  浏览/下载:11/0  |  提交时间:2021/03/29
Active methanogenesis during the melting of Marinoan snowball Earth 期刊论文
Nature Communications, 2021
作者:  Zhouqiao Zhao;  Bing Shen;  Jian-Ming Zhu;  Xianguo Lang;  Guangliang Wu;  Decan Tan;  Haoxiang Pei;  Tianzheng Huang;  Meng Ning;  Haoran Ma
收藏  |  浏览/下载:8/0  |  提交时间:2021/02/17
Chemical vapor deposition of layered two-dimensional MoSi2N4 materials 期刊论文
Science, 2020
作者:  Yi-Lun Hong;  Zhibo Liu;  Lei Wang;  Tianya Zhou;  Wei Ma;  Chuan Xu;  Shun Feng;  Long Chen;  Mao-Lin Chen;  Dong-Ming Sun;  Xing-Qiu Chen;  Hui-Ming Cheng;  Wencai Ren
收藏  |  浏览/下载:27/0  |  提交时间:2020/08/18
Notch signalling drives synovial fibroblast identity and arthritis pathology 期刊论文
NATURE, 2020, 582 (7811) : 259-+
作者:  Han, Xiaoping;  Zhou, Ziming;  Fei, Lijiang;  Sun, Huiyu;  Wang, Renying;  Chen, Yao;  Chen, Haide;  Wang, Jingjing;  Tang, Huanna;  Ge, Wenhao;  Zhou, Yincong;  Ye, Fang;  Jiang, Mengmeng;  Wu, Junqing;  Xiao, Yanyu;  Jia, Xiaoning;  Zhang, Tingyue;  Ma, Xiaojie;  Zhang, Qi;  Bai, Xueli;  Lai, Shujing;  Yu, Chengxuan;  Zhu, Lijun;  Lin, Rui;  Gao, Yuchi;  Wang, Min;  Wu, Yiqing;  Zhang, Jianming;  Zhan, Renya;  Zhu, Saiyong;  Hu, Hailan;  Wang, Changchun;  Chen, Ming;  Huang, He;  Liang, Tingbo;  Chen, Jianghua;  Wang, Weilin;  Zhang, Dan;  Guo, Guoji
收藏  |  浏览/下载:43/0  |  提交时间:2020/07/03

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.


The synovium is a mesenchymal tissue composed mainly of fibroblasts, with a lining and sublining that surround the joints. In rheumatoid arthritis the synovial tissue undergoes marked hyperplasia, becomes inflamed and invasive, and destroys the joint(1,2). It has recently been shown that a subset of fibroblasts in the sublining undergoes a major expansion in rheumatoid arthritis that is linked to disease activity(3-5)  however, the molecular mechanism by which these fibroblasts differentiate and expand is unknown. Here we identify a critical role for NOTCH3 signalling in the differentiation of perivascular and sublining fibroblasts that express CD90 (encoded by THY1). Using single-cell RNA sequencing and synovial tissue organoids, we found that NOTCH3 signalling drives both transcriptional and spatial gradients-emanating from vascular endothelial cells outwards-in fibroblasts. In active rheumatoid arthritis, NOTCH3 and Notch target genes are markedly upregulated in synovial fibroblasts. In mice, the genetic deletion of Notch3 or the blockade of NOTCH3 signalling attenuates inflammation and prevents joint damage in inflammatory arthritis. Our results indicate that synovial fibroblasts exhibit a positional identity that is regulated by endothelium-derived Notch signalling, and that this stromal crosstalk pathway underlies inflammation and pathology in inflammatory arthritis.


  
Nagaoka ferromagnetism observed in a quantum dot plaquette 期刊论文
NATURE, 2020, 579 (7800) : 528-533
作者:  Yu, Yong;  Ma, Fei;  Luo, Xi-Yu;  Jing, Bo;  Sun, Peng-Fei;  Fang, Ren-Zhou;  Yang, Chao-Wei;  Liu, Hui;  Zheng, Ming-Yang;  Xie, Xiu-Ping;  Zhang, Wei-Jun;  You, Li-Xing;  Wang, Zhen;  Chen, Teng-Yun;  Zhang, Qiang;  Bao, Xiao-Hui;  Pan, Jian-Wei
收藏  |  浏览/下载:31/0  |  提交时间:2020/07/03

A quantum dot device designed to host four electrons is used to demonstrate Nagaoka ferromagnetism-a model of itinerant magnetism that has so far been limited to theoretical investigation.


Engineered, highly controllable quantum systems are promising simulators of emergent physics beyond the simulation capabilities of classical computers(1). An important problem in many-body physics is itinerant magnetism, which originates purely from long-range interactions of free electrons and whose existence in real systems has been debated for decades(2,3). Here we use a quantum simulator consisting of a four-electron-site square plaquette of quantum dots(4) to demonstrate Nagaoka ferromagnetism(5). This form of itinerant magnetism has been rigorously studied theoretically(6-9) but has remained unattainable in experiments. We load the plaquette with three electrons and demonstrate the predicted emergence of spontaneous ferromagnetic correlations through pairwise measurements of spin. We find that the ferromagnetic ground state is remarkably robust to engineered disorder in the on-site potentials and we can induce a transition to the low-spin state by changing the plaquette topology to an open chain. This demonstration of Nagaoka ferromagnetism highlights that quantum simulators can be used to study physical phenomena that have not yet been observed in any experimental system. The work also constitutes an important step towards large-scale quantum dot simulators of correlated electron systems.


  
A genome-wide association study identifies six novel risk loci for primary biliary cholangitis 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Qiu, Fang;  Tang, Ruqi;  Zuo, Xianbo;  Shi, Xingjuan;  Wei, Yiran;  Zheng, Xiaodong;  Dai, Yaping;  Gong, Yuhua;  Wang, Lan;  Xu, Ping;  Zhu, Xiang;  Wu, Jian;  Han, Chongxu;  Gao, Yueqiu;  Zhang, Kui;  Jiang, Yuzhang;  Zhou, Jianbo;  Shao, Youlin;  Hu, Zhigang;  Tian, Ye;  Zhang, Haiyan;  Dai, Na;  Liu, Lei;  Wu, Xudong;  Zhao, Weifeng;  Zhang, Xiaomin;  Zang, Zhidong;  Nie, Jinshan;  Sun, Weihao;  Zhao, Yi;  Mao, Yuan;  Jiang, Po;  Ji, Hualiang;  Dong, Qing;  Li, Junming;  Li, Zhenzhong;  Bai, Xinli;  Li, Li;  Lin, Maosong;  Dong, Ming;  Li, Jinxin;  Zhu, Ping;  Wang, Chan;  Zhang, Yanqiu;  Jiang, Peng;  Wang, Yujue;  Jawed, Rohil;  Xu, Jing;  Zhang, Yu;  Wang, Qixia;  Yang, Yue;  Yang, Fan;  Lian, Min;  Jiang, Xiang;  Xiao, Xiao;  Li, Yanmei;  Fang, Jingyuan;  Qiu, Dekai;  Zhu, Zhen;  Qiu, Hong;  Zhang, Jianqiong;  Tian, Wenyan;  Chen, Sufang;  Jiang, Ling;  Ji, Bing;  Li, Ping;  Chen, Guochang;  Wu, Tianxue;  Sun, Yan;  Yu, Jianjiang;  Tang, Huijun;  He, Michun;  Xia, Min;  Pei, Hao;  Huang, Lihua;  Qing, Zhuye;  Wu, Jianfang;  Huang, Qinghai;  Han, Junhai;  Xie, Wei;  Sun, Zhongsheng;  Guo, Jian;  He, Gengsheng;  Gershwin, M. Eric;  Lian, Zhexiong;  Liu, Xiang;  Seldin, Michael F.;  Liu, Xiangdong;  Chen, Weichang;  Ma, Xiong
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
Device-independent quantum random-number generation 期刊论文
NATURE, 2018, 562 (7728) : 548-+
作者:  Liu, Yang;  Zhao, Qi;  Li, Ming-Han;  Guan, Jian-Yu;  Zhang, Yanbao;  Bai, Bing;  Zhang, Weijun;  Liu, Wen-Zhao;  Wu, Cheng;  Yuan, Xiao;  Li, Hao;  Munro, W. J.;  Wang, Zhen;  You, Lixing;  Zhang, Jun;  Ma, Xiongfeng;  Fan, Jingyun;  Zhang, Qiang;  Pan, Jian-Wei
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Structure and dynamics of the active human parathyroid hormone receptor-1 期刊论文
SCIENCE, 2019, 364 (6436) : 148-+
作者:  Zhao, Li-Hua;  Ma, Shanshan;  Sutkeviciute, Ieva;  Shen, Dan-Dan;  Zhou, X. Edward;  de Waal, Parker W.;  Li, Chen-Yao;  Kang, Yanyong;  Clark, Lisa J.;  Jean-Alphonse, Frederic G.;  White, Alex D.;  Yang, Dehua;  Dai, Antao;  Cai, Xiaoqing;  Chen, Jian;  Li, Cong;  Jiang, Yi;  Watanabe, Tomoyuki;  Gardella, Thomas J.;  Melcher, Karsten;  Wang, Ming-Wei;  Vilardaga, Jean-Pierre;  Xu, H. Eric;  Zhang, Yan
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Chiral expression from molecular to macroscopic level via pH modulation in terbium coordination polymers 期刊论文
NATURE COMMUNICATIONS, 2017, 8
作者:  Huang, Jian;  Ding, Hong-ming;  Xu, Yan;  Zeng, Dai;  Zhu, Hui;  Zang, Dong-Mian;  Bao, Song-Song;  Ma, Yu-qiang;  Zheng, Li-Min
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27