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Nanoplasma-enabled picosecond switches for ultrafast electronics (vol 579, pg 534, 2020) 期刊论文
NATURE, 2020, 580 (7803) : E8-E8
作者:  Li, Jing;  Xu, Chuanliang;  Lee, Hyung Joo;  Ren, Shancheng;  Zi, Xiaoyuan;  Zhang, Zhiming;  Wang, Haifeng;  Yu, Yongwei;  Yang, Chenghua;  Gao, Xiaofeng;  Hou, Jianguo;  Wang, Linhui;  Yang, Bo;  Yang, Qing;  Ye, Huamao;  Zhou, Tie;  Lu, Xin;  Wang, Yan;  Qu, Min;  Yang, Qingsong;  Zhang, Wenhui;  Shah, Nakul M.;  Pehrsson, Erica C.;  Wang, Shuo;  Wang, Zengjun;  Jiang, Jun;  Zhu, Yan;  Chen, Rui;  Chen, Huan;  Zhu, Feng;  Lian, Bijun;  Li, Xiaoyun;  Zhang, Yun;  Wang, Chao;  Wang, Yue;  Xiao, Guangan;  Jiang, Junfeng;  Yang, Yue;  Liang, Chaozhao;  Hou, Jianquan;  Han, Conghui;  Chen, Ming;  Jiang, Ning;  Zhang, Dahong;  Wu, Song;  Yang, Jinjian;  Wang, Tao;  Chen, Yongliang;  Cai, Jiantong;  Yang, Wenzeng;  Xu, Jun;  Wang, Shaogang;  Gao, Xu;  Wang, Ting;  Sun, Yinghao
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/03
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:142/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
High thermoelectric performance in low-cost SnS0.91Se0.09 crystals 期刊论文
SCIENCE, 2019, 365 (6460) : 1418-+
作者:  He, Wenke;  Wang, Dongyang;  Wu, Haijun;  Xiao, Yu;  Zhang, Yang;  He, Dongsheng;  Feng, Yue;  Hao, Yu-Jie;  Dong, Jin-Feng;  Chetty, Raju;  Hao, Lijie;  Chen, Dongfeng;  Qin, Jianfei;  Yang, Qiang;  Li, Xin;  Song, Jian-Ming;  Zhu, Yingcai;  Xu, Wei;  Niu, Changlei;  Li, Xin;  Wang, Guangtao;  Liu, Chang;  Ohta, Michibiro;  Pennycook, Stephen J.;  He, Jiaqing;  Li, Jing-Feng;  Zhao, Li-Dong
收藏  |  浏览/下载:22/0  |  提交时间:2019/11/27
Organic and solution-processed tandem solar cells with 17.3% efficiency 期刊论文
SCIENCE, 2018, 361 (6407) : 1094-+
作者:  Meng, Lingxian;  Zhang, Yamin;  Wan, Xiangjian;  Li, Chenxi;  Zhang, Xin;  Wang, Yanbo;  Ke, Xin;  Xiao, Zuo;  Ding, Liming;  Xia, Ruoxi;  Yip, Hin-Lap;  Cao, Yong;  Chen, Yongsheng
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Atmospheric new particle formation from sulfuric acid and amines in a Chinese megacity 期刊论文
SCIENCE, 2018, 361 (6399) : 278-+
作者:  Yao, Lei;  Garmash, Olga;  Bianchi, Federico;  Zheng, Jun;  Yan, Chao;  Kontkanen, Jenni;  Junninen, Heikki;  Mazon, Stephany Buenrostro;  Ehn, Mikael;  Paasonen, Pauli;  Sipila, Mikko;  Wang, Mingyi;  Wang, Xinke;  Xiao, Shan;  Chen, Hangfei;  Lu, Yiqun;  Zhang, Bowen;  Wang, Dongfang;  Fu, Qingyan;  Geng, Fuhai;  Li, Li;  Wang, Hongli;  Qiao, Liping;  Yang, Xin;  Chen, Jianmin;  Kerminen, Veli-Matti;  Petaja, Tuukka;  Worsnop, Douglas R.;  Kulmala, Markku;  Wang, Lin
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Urbanization prolongs hantavirus epidemics in cities 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (18) : 4707-4712
作者:  Tian, Huaiyu;  Hu, Shixiong;  Cazelles, Bernard;  Chowell, Gerardo;  Gao, Lidong;  Laine, Marko;  Li, Yapin;  Yang, Huisuo;  Li, Yidan;  Yang, Qiqi;  Tong, Xin;  Huang, Ru;  Bjornstad, Otter N.;  Xiao, Hong;  Stenseth, Nils Chr.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
urbanization  immigration  hantavirus  endemic turning point  China  
Chaos-assisted broadband momentum transformation in optical microresonators 期刊论文
SCIENCE, 2017, 358 (6361) : 344-+
作者:  Jiang, Xuefeng;  Shao, Linbo;  Zhang, Shu-Xin;  Yi, Xu;  Wiersig, Jan;  Wang, Li;  Gong, Qihuang;  Loncar, Marko;  Yang, Lan;  Xiao, Yun-Feng
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
"Perfect" designer chromosome V and behavior of a ring derivative 期刊论文
SCIENCE, 2017, 355 (6329)
作者:  Xie, Ze-Xiong;  Li, Bing-Zhi;  Mitchell, Leslie A.;  Wu, Yi;  Qi, Xin;  Jin, Zhu;  Jia, Bin;  Wang, Xia;  Zeng, Bo-Xuan;  Liu, Hui-Min;  Wu, Xiao-Le;  Feng, Qi;  Zhang, Wen-Zheng;  Liu, Wei;  Ding, Ming-Zhu;  Li, Xia;  Zhao, Guang-Rong;  Qiao, Jian-Jun;  Cheng, Jing-Sheng;  Zhao, Meng;  Kuang, Zheng;  Wang, Xuya;  Martin, J. Andrew;  Stracquadanio, Giovanni;  Yang, Kun;  Bai, Xue;  Zhao, Juan;  Hu, Meng-Long;  Lin, Qiu-Hui;  Zhang, Wen-Qian;  Shen, Ming-Hua;  Chen, Si;  etc
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27