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A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：37/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Torsional refrigeration by twisted, coiled, and supercoiled fibers 期刊论文
SCIENCE, 2019, 366 (6462) : 216-+
作者:  Wang, Run;  Fang, Shaoli;  Xiao, Yicheng;  Gao, Enlai;  Jiang, Nan;  Li, Yaowang;  Mou, Linlin;  Shen, Yanan;  Zhao, Wubin;  Li, Sitong;  Fonseca, Alexandre F.;  Galvao, Douglas S.;  Chen, Mengmeng;  He, Wenqian;  Yu, Kaiqing;  Lu, Hongbing;  Wang, Xuemin;  Qian, Dong;  Aliev, Ali E.;  Li, Na;  Haines, Carter S.;  Liu, Zhongsheng;  Mu, Jiuke;  Wang, Zhong;  Yin, Shougen;  Lima, Marcio D.;  An, Baigang;  Zhou, Xiang;  Liu, Zunfeng;  Baughman, Ray H.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
The human imperative of stabilizing global climate change at 1.5 degrees C 期刊论文
SCIENCE, 2019, 365 (6459) : 1263-+
作者:  Hoegh-Guldberg, O.;  Jacob, D.;  Taylor, M.;  Bolanos, T. Guillen;  Bindi, M.;  Brown, S.;  Camilloni, I. A.;  Diedhiou, A.;  Djalante, R.;  Ebi, K.;  Engelbrecht, F.;  Guiot, J.;  Hijioka, Y.;  Mehrotra, S.;  Hope, C. W.;  Payne, A. J.;  Poertner, H. -O.;  Seneviratne, S. I.;  Thomas, A.;  Warren, R.;  Zhou, G.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Giant thermal Hall conductivity in the pseudogap phase of cuprate superconductors 期刊论文
NATURE, 2019, 571 (7765) : 376-+
作者:  Grissonnanche, G.;  Legros, A.;  Badoux, S.;  Lefrancois, E.;  Zatko, V.;  Lizaire, M.;  Laliberte, F.;  Gourgout, A.;  Zhou, J. -S.;  Pyon, S.;  Takayama, T.;  Takagi, H.;  Ono, S.;  Doiron-Leyraud, N.;  Taillefer, L.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/27
Structure and dynamics of the active human parathyroid hormone receptor-1 期刊论文
SCIENCE, 2019, 364 (6436) : 148-+
作者:  Zhao, Li-Hua;  Ma, Shanshan;  Sutkeviciute, Ieva;  Shen, Dan-Dan;  Zhou, X. Edward;  de Waal, Parker W.;  Li, Chen-Yao;  Kang, Yanyong;  Clark, Lisa J.;  Jean-Alphonse, Frederic G.;  White, Alex D.;  Yang, Dehua;  Dai, Antao;  Cai, Xiaoqing;  Chen, Jian;  Li, Cong;  Jiang, Yi;  Watanabe, Tomoyuki;  Gardella, Thomas J.;  Melcher, Karsten;  Wang, Ming-Wei;  Vilardaga, Jean-Pierre;  Xu, H. Eric;  Zhang, Yan
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Multiphase reactivity of polycyclic aromatic hydrocarbons is driven by phase separation and diffusion limitations 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (24) : 11658-11663
作者:  Zhou, Shouming;  Hwang, Brian C. H.;  Lakey, Pascale S. J.;  Zuend, Andreas;  Abbatt, Jonathan P. D.;  Shiraiwa, Manabu
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
phase state  ozone  indoor chemistry  bulk diffusion  kinetic modeling  
Comprehensive functional genomic resource and integrative model for the human brain 期刊论文
SCIENCE, 2018, 362 (6420) : 1266-+
作者:  Wang, Daifeng;  Liu, Shuang;  Warrell, Jonathan;  Won, Hyejung;  Shi, Xu;  Navarro, Fabio C. P.;  Clarke, Declan;  Gu, Mengting;  Emani, Prashant;  Yang, Yucheng T.;  Xu, Min;  Gandal, Michael J.;  Lou, Shaoke;  Zhang, Jing;  Park, Jonathan J.;  Yan, Chengfei;  Rhie, Suhn Kyong;  Manakongtreecheep, Kasidet;  Zhou, Holly;  Nathan, Aparna;  Peters, Mette;  Mattei, Eugenio;  Fitzgerald, Dominic;  Brunetti, Tonya;  Moore, Jill;  Jiang, Yan;  Girdhar, Kiran;  Hoffman, Gabriel E.;  Kalayci, Selim;  Gumus, Zeynep H.;  Crawford, Gregory E.;  Roussos, Panos;  Akbarian, Schahram;  Jaffe, Andrew E.;  White, Kevin P.;  Weng, Zhiping;  Sestan, Nenad;  Geschwind, Daniel H.;  Knowles, James A.;  Gerstein, Mark B.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/27
The earliest human occupation of the high-altitude Tibetan Plateau 40 thousand to 30 thousand years ago 期刊论文
SCIENCE, 2018, 362 (6418) : 1049-+
作者:  Zhang, X. L.;  Ha, B. B.;  Wang, S. J.;  Chen, Z. J.;  Ge, J. Y.;  Long, H.;  He, W.;  Da, W.;  Nian, X. M.;  Yi, M. J.;  Zhou, X. Y.;  Zhang, P. Q.;  Jin, Y. S.;  Bar-Yosef, O.;  Olsen, J. W.;  Gao, X.
收藏  |  浏览/下载：21/0  |  提交时间：2019/11/27
The chromatin accessibility landscape of primary human cancers 期刊论文
SCIENCE, 2018, 362 (6413) : 420-+
作者:  Corces, M. Ryan;  Granja, Jeffrey M.;  Shams, Shadi;  Louie, Bryan H.;  Seoane, Jose A.;  Zhou, Wanding;  Silva, Tiago C.;  Groeneveld, Clarice;  Wong, Christopher K.;  Cho, Seung Woo;  Satpathy, Ansuman T.;  Mumbach, Maxwell R.;  Hoadley, Katherine A.;  Robertson, A. Gordon;  Sheffield, Nathan C.;  Felau, Ina;  Castro, Mauro A. A.;  Berman, Benjamin P.;  Staudt, Louis M.;  Zenklusen, Jean C.;  Laird, Peter W.;  Curtis, Christina;  Greenleaf, William J.;  Chang, Howard Y.
收藏  |  浏览/下载：17/0  |  提交时间：2019/11/27
Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (38) : 9592-9597
作者:  Burnett, Richard;  Chen, Hong;  Szyszkowicz, Mieczyslaw;  Fann, Neal;  Hubbell, Bryan;  Pope, C. Arden;  Apte, Joshua S.;  Brauer, Michael;  Cohen, Aaron;  Weichenthal, Scott;  Coggins, Jay;  Di, Qian;  Brunekreef, Bert;  Frostad, Joseph;  Lim, Stephen S.;  Kan, Haidong;  Walker, Katherine D.;  Thurston, George D.;  Hayes, Richard B.;  Lim, Chris C.;  Turner, Michelle C.;  Jerrett, Michael;  Krewski, Daniel;  Gapstur, Susan M.;  Diver, W. Ryan;  Ostro, Bart;  Goldberg, Debbie;  Crouse, Daniel L.;  Martin, Randall V.;  Peters, Paul;  Pinault, Lauren;  Tjepkema, Michael;  van Donkelaar, Aaron;  Villeneuve, Paul J.;  Miller, Anthony B.;  Yin, Peng;  Zhou, Maigeng;  Wang, Lijun;  Janssen, Nicole A. H.;  Marra, Marten;  Atkinson, Richard W.;  Tsang, Hilda;  Thuan Quoc Thach;  Cannon, John B.;  Allen, Ryan T.;  Hart, Jaime E.;  Laden, Francine;  Cesaroni, Giulia;  Forastiere, Francesco;  Weinmayr, Gudrun;  Jaensch, Andrea;  Nagel, Gabriele;  Concin, Hans;  Spadaro, Joseph V.
收藏  |  浏览/下载：54/0  |  提交时间：2019/11/27
mortality  exposure  risk  concentration  fine particulate matter