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SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model 期刊论文
Science, 2021
作者:  Jingxin Qiao;  Yue-Shan Li;  Rui Zeng;  Feng-Liang Liu;  Rong-Hua Luo;  Chong Huang;  Yi-Fei Wang;  Jie Zhang;  Baoxue Quan;  Chenjian Shen;  Xin Mao;  Xinlei Liu;  Weining Sun;  Wei Yang;  Xincheng Ni;  Kai Wang;  Ling Xu;  Zi-Lei Duan;  Qing-Cui Zou;  Hai-Lin Zhang;  Wang Qu;  Yang-Hao-Peng Long;  Ming-Hua Li;  Rui-Cheng Yang;  Xiaolong Liu;  Jing You;  Yangli Zhou;  Rui Yao;  Wen-Pei Li;  Jing-Ming Liu;  Pei Chen;  Yang Liu;  Gui-Feng Lin;  Xin Yang;  Jun Zou;  Linli Li;  Yiguo Hu;  Guang-Wen Lu;  Wei-Min Li;  Yu-Quan Wei;  Yong-Tang Zheng;  Jian Lei;  Shengyong Yang
收藏  |  浏览/下载:14/0  |  提交时间:2021/04/06
Sequential C–F bond functionalizations of trifluoroacetamides and acetates via spin-center shifts 期刊论文
Science, 2021
作者:  You-Jie Yu;  Feng-Lian Zhang;  Tian-Yu Peng;  Chang-Ling Wang;  Jie Cheng;  Chen Chen;  Kendall N. Houk;  Yi-Feng Wang
收藏  |  浏览/下载:23/0  |  提交时间:2021/03/29
Structural basis for neutralization of SARS-CoV-2 and SARS-CoV by a potent therapeutic antibody 期刊论文
Science, 2020
作者:  Zhe Lv;  Yong-Qiang Deng;  Qing Ye;  Lei Cao;  Chun-Yun Sun;  Changfa Fan;  Weijin Huang;  Shihui Sun;  Yao Sun;  Ling Zhu;  Qi Chen;  Nan Wang;  Jianhui Nie;  Zhen Cui;  Dandan Zhu;  Neil Shaw;  Xiao-Feng Li;  Qianqian Li;  Liangzhi Xie;  Youchun Wang;  Zihe Rao;  Cheng-Feng Qin;  Xiangxi Wang
收藏  |  浏览/下载:16/0  |  提交时间:2020/09/22
A map of object space in primate inferotemporal cortex 期刊论文
NATURE, 2020, 583 (7814) : 103-+
作者:  Wu, Huihui;  Li, Bosheng;  Iwakawa, Hiro-oki;  Pan, Yajie;  Tang, Xianli;  Ling-hu, Qianyan;  Liu, Yuelin;  Sheng, Shixin;  Feng, Li;  Zhang, Hong;  Zhang, Xinyan;  Tang, Zhonghua;  Xia, Xinli;  Zhai, Jixian;  Guo, Hongwei
收藏  |  浏览/下载:47/0  |  提交时间:2020/07/03

Primate inferotemporal cortex contains a coarse map of object space consisting of four networks, identified using functional imaging, electrophysiology and deep networks.


The inferotemporal (IT) cortex is responsible for object recognition, but it is unclear how the representation of visual objects is organized in this part of the brain. Areas that are selective for categories such as faces, bodies, and scenes have been found(1-5), but large parts of IT cortex lack any known specialization, raising the question of what general principle governs IT organization. Here we used functional MRI, microstimulation, electrophysiology, and deep networks to investigate the organization of macaque IT cortex. We built a low-dimensional object space to describe general objects using a feedforward deep neural network trained on object classification(6). Responses of IT cells to a large set of objects revealed that single IT cells project incoming objects onto specific axes of this space. Anatomically, cells were clustered into four networks according to the first two components of their preferred axes, forming a map of object space. This map was repeated across three hierarchical stages of increasing view invariance, and cells that comprised these maps collectively harboured sufficient coding capacity to approximately reconstruct objects. These results provide a unified picture of IT organization in which category-selective regions are part of a coarse map of object space whose dimensions can be extracted from a deep network.


  
The wide-binary origin of (2014) MU69-like Kuiper belt contact binaries (vol 31, pg 878, 2020) 期刊论文
NATURE, 2020, 582 (7811) : E2-E2
作者:  Wu, Huihui;  Li, Bosheng;  Iwakawa, Hiro-oki;  Pan, Yajie;  Tang, Xianli;  Ling-hu, Qianyan;  Liu, Yuelin;  Sheng, Shixin;  Feng, Li;  Zhang, Hong;  Zhang, Xinyan;  Tang, Zhonghua;  Xia, Xinli;  Zhai, Jixian;  Guo, Hongwei
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03
Multi-model analysis of climate impacts on plant photosynthesis in China during 2000-2015 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (15) : 5539-5555
作者:  Yan, Hao;  Wang, Shao-Qiang;  Cao, Yun;  Xu, Ling-Ling;  Wu, Men-xin;  Cheng, Lu;  Mao, Liu-Xi;  Zhang, Xian-Zhou;  Liu, Yun-Fen;  Wang, Yan-Fen;  Chen, Shi-Ping;  Li, Ying-Nian;  Han, Shi-Jie;  Zhou, Guo-Yi;  Zhang, Yi-Ping;  Shugart, Herman H.;  Wang, Jun-Bang;  Zhao, Feng-Hua
收藏  |  浏览/下载:13/0  |  提交时间:2020/02/17
climate change  dry/wet climate  Gross primary production  meteorological factors  multi-model analysis  
Multidecadal- to Centennial-Scale Be-10 Variations in Holocene Sediments of Huguangyan Maar Lake, South China 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (13) : 7634-7642
作者:  Tang, Ling;  Zhou, Weijian;  Wang, Xisheng;  Xian, Feng;  Du, Yajuan;  Zhou, Jie;  Chu, Guoqiang;  Zhao, Guoqing;  Zhang, Li
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Limited potential of harvest index improvement to reduce methane emissions from rice paddies 期刊论文
GLOBAL CHANGE BIOLOGY, 2019, 25 (2) : 686-698
作者:  Jiang, Yu;  Qian, Haoyu;  Wang, Ling;  Feng, Jinfei;  Huang, Shan;  Hungate, Bruce A.;  van Kessel, Chris;  Horwath, William R.;  Zhang, Xingyue;  Qin, Xiaobo;  Li, Yue;  Feng, Xiaomin;  Zhang, Jun;  Deng, Aixing;  Zheng, Chenyan;  Song, Zhenwei;  Hu, Shuijin;  van Groenigen, Kees Jan;  Zhang, Weijian
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
climate change  food security  greenhouse gases  meta-analysis  water management  
Neoproterozoic Low-delta O-18 Zircons Revisited: Implications for Rodinia Configuration 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (2) : 678-688
作者:  Huang, Ding-Ling;  Wang, Xiao-Lei;  Xia, Xiao-Ping;  Wan, Yu-Sheng;  Zhang, Feng-Feng;  Li, Jun-Yong;  Du, De-Hong
收藏  |  浏览/下载:6/0  |  提交时间:2019/04/09
Urbanization effects on changes in the observed air temperatures during 1977-2014 in China 期刊论文
INTERNATIONAL JOURNAL OF CLIMATOLOGY, 2019, 39 (1) : 251-265
作者:  Li, Yuanzheng;  Wang, Lan;  Zhou, Hongxuan;  Zhao, Guosong;  Ling, Feng;  Li, Xiaodong;  Qiu, Juan
收藏  |  浏览/下载:5/0  |  提交时间:2019/04/09
homogenization  land use and land cover  nighttime light  reference station  regionalization  self-organizing maps  temperature change