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Measurement report: Distinct size dependence and diurnal variation in organic aerosol hygroscopicity, volatility, and cloud condensation nuclei activity at a rural site in the Pearl River Delta (PRD) region, China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Mingfu Cai, Shan Huang, Baoling Liang, Qibin Sun, Li Liu, Bin Yuan, Min Shao, Weiwei Hu, Wei Chen, Qicong Song, Wei Li, Yuwen Peng, Zelong Wang, Duohong Chen, Haobo Tan, Hanbin Xu, Fei Li, Xuejiao Deng, Tao Deng, Jiaren Sun, and Jun Zhao
收藏  |  浏览/下载:16/0  |  提交时间:2022/06/24
The nitrogen budget of laboratory-simulated western US wildfires during the FIREX 2016 Fire Lab study 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  James M. Roberts, Chelsea E. Stockwell, Robert J. Yokelson, Joost de Gouw, Yong Liu, Vanessa Selimovic, Abigail R. Koss, Kanako Sekimoto, Matthew M. Coggon, Bin Yuan, Kyle J. Zarzana, Steven S. Brown, Cristina Santin, Stefan H. Doerr, and Carsten Warneke
收藏  |  浏览/下载:14/0  |  提交时间:2020/08/09
Air Quality Impact of the Northern California Camp Fire of November 2018 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Brigitte Rooney, Yuan Wang, Jonathan H. Jiang, Bin Zhao, Zhao-Cheng Zeng, and John H. Seinfeld
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/09
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
OH chemistry of non-methane organic gases (NMOGs) emitted from laboratory and ambient biomass burning smoke: evaluating the influence of furans and oxygenated aromatics on ozone and secondary NMOG formation 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (23) : 14875-14899
作者:  Coggon, Matthew M.;  Lim, Christopher Y.;  Koss, Abigail R.;  Sekimoto, Kanako;  Yuan, Bin;  Gilman, Jessica B.;  Hagan, David H.;  Selimovic, Vanessa;  Zarzana, Kyle J.;  Brown, Steven S.;  Roberts, James M.;  Mueller, Markus;  Yokelson, Robert;  Wisthaler, Armin;  Krechmer, Jordan E.;  Jimenez, Jose L.;  Cappa, Christopher;  Kroll, Jesse H.;  de Gouw, Joost;  Warneke, Carsten
收藏  |  浏览/下载:19/0  |  提交时间:2020/02/17
Ice nucleation by aerosols from anthropogenic pollution 期刊论文
NATURE GEOSCIENCE, 2019, 12 (8) : 602-+
作者:  Zhao, Bin;  Wang, Yuan;  Gu, Yu;  Liou, Kuo-Nan;  Jiang, Jonathan H.;  Fan, Jiwen;  Liu, Xiaohong;  Huang, Lei;  Yung, Yuk L.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits 期刊论文
SCIENCE, 2019, 364 (6446) : 1152-+
作者:  Chen, Lei;  Qin, Qiang;  Jiang, Yu;  Wang, Kun;  Lin, Zeshan;  Li, Zhipeng;  Bibi, Faysal;  Yang, Yongzhi;  Wang, Jinhuan;  Nie, Wenhui;  Su, Weiting;  Liu, Guichun;  Li, Qiye;  Fu, Weiwei;  Pan, Xiangyu;  Liu, Chang;  Yang, Jie;  Zhang, Chenzhou;  Yin, Yuan;  Wang, Yu;  Zhao, Yue;  Zhang, Chen;  Wang, Zhongkai;  Qin, Yanli;  Liu, Wei;  Wang, Bao;  Ren, Yandong;  Zhang, Ru;  Zeng, Yan;  da Fonseca, Rute R.;  Wei, Bin;  Li, Ran;  Wan, Wenting;  Zhao, Ruoping;  Zhu, Wenbo;  Wang, Yutao;  Duan, Shengchang;  Gao, Yun;  Zhang, Yong E.;  Chen, Chunyan;  Hvilsom, Christina;  Epps, Clinton W.;  Chemnick, Leona G.;  Doug, Yang;  Mirarab, Siavash;  Siegismund, Hans Redlef;  Ryder, Oliver A.;  Gilbert, M. Thomas P.;  Lewin, Harris A.;  Zhang, Guojie;  Heller, Rasmus;  Wang, Wen
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27
Change in household fuels dominates the decrease in PM2.5 exposure and premature mortality in China in 2005-2015 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (49) : 12401-12406
作者:  Zhao, Bin;  Zheng, Haotian;  Wang, Shuxiao;  Smith, Kirk R.;  Lu, Xi;  Aunan, Kristin;  Gu, Yu;  Wang, Yuan;  Ding, Dian;  Xing, Jia;  Fu, Xiao;  Yang, Xudong;  Liou, Kuo-Nan;  Hao, Jiming
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
health impact  household air pollution  ambient air pollution  integrated exposure assessment  cooking  
Statistical and hydrological evaluation of the latest Integrated Multi-satellitE Retrievals for GPM (IMERG) over a midlatitude humid basin in South China 期刊论文
ATMOSPHERIC RESEARCH, 2018, 214: 418-429
作者:  Jiang, Shanhu;  Ren, Liliang;  Xu, Chong-Yu;  Yong, Bin;  Yuan, Fei;  Liu, Yi;  Yang, Xiaoli;  Zeng, Xinmin
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
Satellite precipitation product  GPM IMERG  Statistical evaluation  Hydrological utility  Xinanjiang model