GSTDTAP

浏览/检索结果: 共42条,第1-10条 帮助

限定条件    
已选(0)清除 条数/页:   排序方式:
From TRMM to GPM, how do improvements of post/near-real-time satellite precipitation estimates manifest? 期刊论文
Atmospheric Research, 2022
作者:  Zhehui Shen, Bin Yong, Lu Yi, Hao Wu, Hui Xu
收藏  |  浏览/下载:10/0  |  提交时间:2022/01/29
Spatiotemporal heterogeneity of snow cover in the central and western Karakoram Mountains based on a refined MODIS product during 2002–2018 期刊论文
Atmospheric Research, 2020
作者:  Ying Yi, Shiyin Liu, Yu Zhu, Kunpeng Wu, ... Muhammad Saifullah
收藏  |  浏览/下载:6/0  |  提交时间:2020/12/07
Spatiotemporal patterns of future temperature and precipitation over China projected by PRECIS under RCPs 期刊论文
Atmospheric Research, 2020
作者:  Yi Wu, Junhong Guo, Haifeng Lin, Jingjie Bai, Xiuquan Wang
收藏  |  浏览/下载:8/0  |  提交时间:2020/10/12
Sm-Nd isochron dating and geochemical (rare earth elements, Sr-87/Sr-86, delta O-18, delta C-13) characterization of calcite veins in the Jiaoshiba shale gas field, China: Implications for the mechanisms of vein formation in shale gas systems 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (7-8) : 1722-1740
作者:  Gao, Jian;  He, Sheng;  Zhao, Jian-xin;  He, Zhiliang;  Wu, Changwu;  Fen, Yuexing;  Ai Duc Nguyen;  Zhou, Jiaxi;  Yi, Zhixing
收藏  |  浏览/下载:12/0  |  提交时间:2020/08/18
Measurement report: Seasonal, distribution and sources of organophosphate esters in PM2.5 from an inland urban city in southwest China 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Hongling Yin, Jiangfeng Liang, Di Wu, Shiping Li, Yi Luo, and Xu Deng
收藏  |  浏览/下载:10/0  |  提交时间:2020/05/20
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Action of a minimal contractile bactericidal nanomachine 期刊论文
NATURE, 2020, 580 (7805) : 658-+
作者:  Peng, Ruchao;  Xu, Xin;  Jing, Jiamei;  Wang, Min;  Peng, Qi;  Liu, Sheng;  Wu, Ying;  Bao, Xichen;  Wang, Peiyi;  Qi, Jianxun;  Gao, George F.;  Shi, Yi
收藏  |  浏览/下载:13/0  |  提交时间:2020/07/03

The authors report near-atomic resolution structures of the R-type bacteriocin from Pseudomonas aeruginosa in the pre-contraction and post-contraction states, and these structures provide insight into the mechanism of action of molecular syringes.


R-type bacteriocins are minimal contractile nanomachines that hold promise as precision antibiotics(1-4). Each bactericidal complex uses a collar to bridge a hollow tube with a contractile sheath loaded in a metastable state by a baseplate scaffold(1,2). Fine-tuning of such nucleic acid-free protein machines for precision medicine calls for an atomic description of the entire complex and contraction mechanism, which is not available from baseplate structures of the (DNA-containing) T4 bacteriophage(5). Here we report the atomic model of the complete R2 pyocin in its pre-contraction and post-contraction states, each containing 384 subunits of 11 unique atomic models of 10 gene products. Comparison of these structures suggests the following sequence of events during pyocin contraction: tail fibres trigger lateral dissociation of baseplate triplexes  the dissociation then initiates a cascade of events leading to sheath contraction  and this contraction converts chemical energy into mechanical force to drive the iron-tipped tube across the bacterial cell surface, killing the bacterium.


  
Impact of Tropical Cyclone Initialization on Its Convection Development and Intensity: A Case Study of Typhoon Megi (2010) 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2020, 77 (2) : 443-464
作者:  Chang, Yi-Pin;  Yang, Shu-Chih;  Lin, Kuan-Jen;  Lien, Guo-Yuan;  Wu, Chien-Ming
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/02
Tropical cyclones  Ensembles  Numerical weather prediction  forecasting  Data assimilation  
Convective Transition Statistics over Tropical Oceans for Climate Model Diagnostics: GCM Evaluation 期刊论文
JOURNAL OF THE ATMOSPHERIC SCIENCES, 2020, 77 (1) : 379-403
作者:  Kuo, Yi-Hung;  Neelin, J. David;  Chen, Chih-Chieh;  Chen, Wei-Ting;  Donner, Leo J.;  Gettelman, Andrew;  Jiang, Xianan;  Kuo, Kuan-Ting;  Maloney, Eric;  Mechoso, Carlos R.;  Ming, Yi;  Schiro, Kathleen A.;  Seman, Charles J.;  Wu, Chien-Ming;  Zhao, Ming
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/02
Climate models  Convective parameterization  Diagnostics  Model evaluation  performance