GSTDTAP

浏览/检索结果: 共27条,第1-10条 帮助

限定条件    
已选(0)清除 条数/页:   排序方式:
Fluxes, patterns and sources of phosphorus deposition in an urban-rural transition region in Southwest China 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Yuanyuan Chen, Jiang Liu, Jiangyou Ran, Rong Huang, Xuesong Gao, Wei Zhou, Ting Lan, Dinghua Ou, Yan He, Yalan Xiong, Ling Luo, Lu Wang, and Ouping Deng
收藏  |  浏览/下载:45/0  |  提交时间:2022/07/08
An improved dark target method for aerosol optical depth retrieval over China from Himawari-8 期刊论文
Atmospheric Research, 2020
作者:  Ling Gao, Lin Chen, Jun Li, Chengcai Li, Lin Zhu
收藏  |  浏览/下载:9/0  |  提交时间:2020/12/07
Evaluation and possible uncertainty source analysis of JAXA Himawari-8 aerosol optical depth product over China 期刊论文
Atmospheric Research, 2020
作者:  Ling Gao, Lin Chen, Chengcai Li, Jun Li, ... Yeping Zhang
收藏  |  浏览/下载:5/0  |  提交时间:2020/09/14
Assessment of atmospheric photochemical reactivity in the Yangtze River Delta using a photochemical box model 期刊论文
Atmospheric Research, 2020
作者:  Weiwen Huang, Qiuyue Zhao, Qian Liu, Feng Chen, ... Zhenhao Ling
收藏  |  浏览/下载:6/0  |  提交时间:2020/06/16
The Great Oxidation Event expanded the genetic repertoire of arsenic metabolism and cycling 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (19) : 10414-10421
作者:  Chen, Song-Can;  Sun, Guo-Xin;  Yan, Yu;  Konstantinidis, Konstantinos T.;  Zhang, Si-Yu;  Deng, Ye;  Li, Xiao-Min;  Cui, Hui-Ling;  Musat, Florin;  Popp, Denny;  Rosen, Barry P.;  Zhu, Yong-Guan
收藏  |  浏览/下载:21/0  |  提交时间:2020/05/13
arsenic  detoxification  evolution  oxygen  biogeochemistry  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Sources of volatile organic compounds and policy implications for regional ozone pollution control in an urban location of Nanjing, East China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (6) : 3905-3919
作者:  Zhao, Qiuyue;  Bi, Jun;  Liu, Qian;  Ling, Zhenghao;  Shen, Guofeng;  Chen, Feng;  Qiao, Yuezhen;  Li, Chunyan;  Ma, Zongwei
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation 期刊论文
SCIENCE, 2019, 366 (6470) : 1215-+
作者:  Saunders, Kevin O.;  Wiehe, Kevin;  Tian, Ming;  Acharya, Priyamvada;  Bradley, Todd;  Alam, S. Munir;  Go, Eden P.;  Scearce, Richard;  Sutherland, Laura;  Henderson, Rory;  Hsu, Allen L.;  Borgnia, Mario J.;  Chen, Haiyan;  Lu, Xiaozhi;  Wu, Nelson R.;  Watts, Brian;  Jiang, Chuancang;  Easterhoff, David;  Cheng, Hwei-Ling;  McGovern, Kelly;  Waddicor, Peyton;  Chapdelaine-Williams, Aimee;  Eaton, Amanda;  Zhang, Jinsong;  Rountree, Wes;  Verkoczy, Laurent;  Tomai, Mark;  Lewis, Mark G.;  Desaire, Heather R.;  Edwards, Robert J.;  Cain, Derek W.;  Bonsignori, Mattia;  Montefiori, David;  Alt, Frederick W.;  Haynes, Barton F.
收藏  |  浏览/下载:12/0  |  提交时间:2020/02/17
DNA-induced 2 ' 3 '-cGAMP enhances haplotype-specific human STING cleavage by dengue protease 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (27) : 15947-15954
作者:  Su, Chan-, I;  Kao, Yu-Ting;  Chang, Chao-Chen;  Chang, Yao;  Ho, Tzong-shiann;  Sun, H. Sunny;  Lin, Yi-Ling;  Lai, Michael M. C.;  Liu, Yu-Huei;  Yu, Chia-Yi
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
STING  DENV protease  SNP  2 '  3 '  -cGAMP  cGAS