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Satellite-derived Constraints on the Effect of Drought Stress on Biogenic Isoprene Emissions in the Southeast US 期刊论文
Atmospheric Chemistry and Physics, 2022
作者:  Yuxuan Wang, Nan Lin, Wei Li, Alex Guenther, Joey C. Y. Lam, Amos P. K. Tai, Mark J. Potosnak, and Roger Seco
收藏  |  浏览/下载:12/0  |  提交时间:2022/06/24
Strategies to reduce PM2.5 and O3 together during late summer and early fall in San Joaquin Valley, California 期刊论文
Atmospheric Research, 2021
作者:  Lin Huang, Jinjin Sun, Ling Jin, Nancy J. Brown, Jianlin Hu
收藏  |  浏览/下载:7/0  |  提交时间:2021/04/29
Description of Atmospheric Aerosol Dynamics Using an Inverse Gaussian Distributed Method of Moments 期刊论文
Journal of the Atmospheric Sciences, 2020
作者:  Shen, J.;  Yu, M.;  Lin, J.
收藏  |  浏览/下载:7/0  |  提交时间:2020/08/25
Past and future decline of tropical pelagic biodiversity 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (23) : 12891-12896
作者:  Yasuhara, Moriaki;  Wei, Chih-Lin;  Kucera, Michal;  Costello, Mark J.;  Tittensor, Derek P.;  Kiessling, Wolfgang;  Bonebrake, Timothy C.;  Tabor, Clay R.;  Feng, Ran;  Baselga, Andres;  Kretschmer, Kerstin;  Kusumoto, Buntarou;  Kubota, Yasuhiro
收藏  |  浏览/下载:12/0  |  提交时间:2020/06/01
latitudinal diversity gradients  planktonic foraminifera  temperature  Last Glacial Maximum  climate change  
Aqueous phase behavior of glyoxal and methylglyoxal observed with carbon and oxygen K-edge X-ray absorption spectroscopy 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Georgia Michailoudi, Jack J. Lin, Hayato Yuzawa, Masanari Nagasaka, Marko Huttula, Nobuhiro Kosugi, Theo Kurtén, Minna Patanen, and Nønne L. Prisle
收藏  |  浏览/下载:7/0  |  提交时间:2020/06/01
Past and future decline of tropical pelagic biodiversity 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Moriaki Yasuhara;  Chih-Lin Wei;  Michal Kucera;  Mark J. Costello;  Derek P. Tittensor;  Wolfgang Kiessling;  Timothy C. Bonebrake;  Clay R. Tabor;  Ran Feng;  Andrés Baselga;  Kerstin Kretschmer;  Buntarou Kusumoto;  Yasuhiro Kubota
收藏  |  浏览/下载:8/0  |  提交时间:2020/06/01
Improvement in municipal wastewater treatment alters lake nitrogen to phosphorus ratios in populated regions 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (21) : 11566-11572
作者:  Tong, Yindong;  Wang, Mengzhu;  Penuelas, Josep;  Liu, Xueyan;  Paerl, Hans W.;  Elser, James J.;  Sardans, Jordi;  Couture, Raoul-Marie;  Larssen, Thorjorn;  Hu, Hongying;  Dong, Xin;  He, Wei;  Zhang, Wei;  Wang, Xuejun;  Zhang, Yang;  Liu, Yi;  Zeng, Siyu;  Kong, Xiangzhen;  Janssen, Annette B. G.;  Lin, Yan
收藏  |  浏览/下载:12/0  |  提交时间:2020/05/13
nutrient balance  water quality change  anthropogenic source  wastewater treatment  aquatic ecosystem  
Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease 期刊论文
NATURE, 2020, 577 (7788) : 103-+
作者:  Lalaoui, Najoua;  Boyden, Steven E.;  Oda, Hirotsugu;  Wood, Geryl M.;  Stone, Deborah L.;  Chau, Diep;  Liu, Lin;  Stoffels, Monique;  Kratina, Tobias;  Lawlor, Kate E.;  Zaal, Kristien J. M.;  Hoffmann, Patrycja M.;  Etemadi, Nima;  Shield-Artin, Kristy;  Biben, Christine;  Tsai, Wanxia Li;  Blake, Mary D.;  Kuehn, Hye Sun;  Yang, Dan;  Anderton, Holly;  Silke, Natasha;  Wachsmuth, Laurens;  Zheng, Lixin;  Moura, Natalia Sampaio;  Beck, David B.;  Gutierrez-Cruz, Gustavo;  Ombrello, Amanda K.;  Pinto-Patarroyo, Gineth P.;  Kueh, Andrew J.;  Herold, Marco J.;  Hall, Cathrine;  Wang, Hongying;  Chae, Jae Jin;  Dmitrieva, Natalia I.;  McKenzie, Mark;  Light, Amanda;  Barham, Beverly K.;  Jones, Anne;  Romeo, Tina M.;  Zhou, Qing;  Aksentijevich, Ivona;  Mullikin, James C.;  Gross, Andrew J.;  Shum, Anthony K.;  Hawkins, Edwin D.;  Masters, Seth L.;  Lenardo, Michael J.;  Boehm, Manfred;  Rosenzweig, Sergio D.;  Pasparakis, Manolis;  Voss, Anne K.;  Gadina, Massimo;  Kastner, Daniel L.;  Silke, John
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

RIPK1 is a key regulator of innate immune signalling pathways. To ensure an optimal inflammatory response, RIPK1 is regulated post-translationally by well-characterized ubiquitylation and phosphorylation events, as well as by caspase-8-mediated cleavage1-7. The physiological relevance of this cleavage event remains unclear, although it is thought to inhibit activation of RIPK3 and necroptosis8. Here we show that the heterozygous missense mutations D324N, D324H and D324Y prevent caspase cleavage of RIPK1 in humans and result in an early-onset periodic fever syndrome and severe intermittent lymphadenopathy-a condition we term '  cleavage-resistant RIPK1-induced autoinflammatory syndrome'  . To define the mechanism for this disease, we generated a cleavage-resistant Ripk1(D325A) mutant mouse strain. Whereas Ripk1(-/-) mice died postnatally from systemic inflammation, Ripk1(D325A/D325A) mice died during embryogenesis. Embryonic lethality was completely prevented by the combined loss of Casp8 and Ripk3, but not by loss of Ripk3 or Mlkl alone. Loss of RIPK1 kinase activity also prevented Ripk1(D325A/D325A) embryonic lethality, although the mice died before weaning from multi-organ inflammation in a RIPK3-dependent manner. Consistently, Ripk1(D325A/D325A) and Ripk1(D325A/+) cells were hypersensitive to RIPK3-dependent TNF-induced apoptosis and necroptosis. Heterozygous Ripk1(D325A/+) mice were viable and grossly normal, but were hyper-responsive to inflammatory stimuli in vivo. Our results demonstrate the importance of caspase-mediated RIPK1 cleavage during embryonic development and show that caspase cleavage of RIPK1 not only inhibits necroptosis but also maintains inflammatory homeostasis throughout life.


  
Pre-deliquescent water uptake in deposited nanoparticles observed with in situ ambient pressure X-ray photoelectron spectroscopy 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Jack J. Lin, Kamal Raj R, Stella Wang, Esko Kokkonen, Mikko-Heikki Mikkelä, Samuli Urpelainen, and Nønne L. Prisle
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/13
Observation of Bose-Einstein condensates in an Earth-orbiting research lab 期刊论文
NATURE, 2020, 582 (7811) : 103-+
作者:  Yamamoto, Keisuke;  Venida, Anthony;  Yano, Julian;  Biancur, Douglas E.;  Kakiuchi, Miwako;  Gupta, Suprit;  Sohn, Albert S. W.;  Mukhopadhyay, Subhadip;  Lin, Elaine Y.;  Parker, Seth J.;  Banh, Robert S.;  Paulo, Joao A.;  Wen, Kwun Wah;  Debnath, Jayanta;  Kim, Grace E.;  Mancias, Joseph D.;  Fearon, Douglas T.;  Perera, Rushika M.;  Kimmelman, Alec C.
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Quantum mechanics governs the microscopic world, where low mass and momentum reveal a natural wave-particle duality. Magnifying quantum behaviour to macroscopic scales is a major strength of the technique of cooling and trapping atomic gases, in which low momentum is engineered through extremely low temperatures. Advances in this field have achieved such precise control over atomic systems that gravity, often negligible when considering individual atoms, has emerged as a substantial obstacle. In particular, although weaker trapping fields would allow access to lower temperatures(1,2), gravity empties atom traps that are too weak. Additionally, inertial sensors based on cold atoms could reach better sensitivities if the free-fall time of the atoms after release from the trap could be made longer(3). Planetary orbit, specifically the condition of perpetual free-fall, offers to lift cold-atom studies beyond such terrestrial limitations. Here we report production of rubidium Bose-Einstein condensates (BECs) in an Earth-orbiting research laboratory, the Cold Atom Lab. We observe subnanokelvin BECs in weak trapping potentials with free-expansion times extending beyond one second, providing an initial demonstration of the advantages offered by a microgravity environment for cold-atom experiments and verifying the successful operation of this facility. With routine BEC production, continuing operations will support long-term investigations of trap topologies unique to microgravity(4,5), atom-laser sources(6), few-body physics(7,8)and pathfinding techniques for atom-wave interferometry(9-12).