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Strong anthropogenic control of secondary organic aerosol formation from isoprene in Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7531-7552
作者:  Bryant, Daniel J.;  Dixon, William J.;  Hopkins, James R.;  Dunmore, Rachel E.;  Pereira, Kelly;  Shaw, Marvin;  Squires, Freya A.;  Bannan, Thomas J.;  Mehra, Archit;  Worrall, Stephen D.;  Bacak, Asan;  Coe, Hugh;  Percival, Carl J.;  Whalley, Lisa K.;  Heard, Dwayne E.;  Slater, Eloise J.;  Ouyang, Bin;  Cui, Tianqu;  Surratt, Jason D.;  Liu, Di;  Shi, Zongbo;  Harrison, Roy;  Sun, Yele;  Xu, Weiqi;  Lewis, Alastair C.;  Lee, James D.;  Rickard, Andrew R.;  Hamilton, Jacqueline F.
收藏  |  浏览/下载：15/0  |  提交时间：2020/08/18
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：35/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Observations of highly oxidized molecules and particle nucleation in the atmosphere of Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (23) : 14933-14947
作者:  Brean, James;  Harrison, Roy M.;  Shi, Zongbo;  Beddows, David C. S.;  Acton, W. Joe F.;  Hewitt, C. Nicholas;  Squires, Freya A.;  Lee, James
收藏  |  浏览/下载：9/0  |  提交时间：2020/02/17
The ice-nucleating ability of quartz immersed in water and its atmospheric importance compared to K-feldspar 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (17) : 11343-11361
作者:  Harrison, Alexander D.;  Lever, Katherine;  Sanchez-Marroquin, Alberto;  Holden, Mark A.;  Whale, Thomas F.;  Tarn, Mark D.;  McQuaid, James B.;  Murray, Benjamin J.
收藏  |  浏览/下载：9/0  |  提交时间：2019/11/27
Secondary magnetite in ancient zircon precludes analysis of a Hadean geodynamo 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (2) : 407-412
作者:  Tang, Fengzai;  Taylor, Richard J. M.;  Einsle, Josh F.;  Borlina, Caue S.;  Fu, Roger R.;  Weiss, Benjamin P.;  Williams, Helen M.;  Williams, Wyn;  Nagy, Lesleis;  Midgley, Paul A.;  Lima, Eduardo A.;  Bell, Elizabeth A.;  Harrison, T. Mark;  Alexander, Ellen W.;  Harrison, Richard J.
收藏  |  浏览/下载：7/0  |  提交时间：2019/11/27
Hadean  paleomagnetism  Jack Hills  zircon  correlative microscopy  
Technical note: Use of an atmospheric simulation chamber to investigate the effect of different engine conditions on unregulated VOC-IVOC diesel exhaust emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (15) : 11073-11096
作者:  Pereira, Kelly L.;  Dunmore, Rachel;  Whitehead, James;  Alfarra, M. Rami;  Allan, James D.;  Alam, Mohammed S.;  Harrison, Roy M.;  McFiggans, Gordon;  Hamilton, Jacqueline F.
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
Spatial and temporal patterns of mass bleaching of corals in the Anthropocene 期刊论文
SCIENCE, 2018, 359 (6371) : 80-+
作者:  Hughes, Terry P.;  Anderson, Kristen D.;  Connolly, Sean R.;  Heron, Scott F.;  Kerry, James T.;  Lough, Janice M.;  Baird, Andrew H.;  Baum, Julia K.;  Berumen, Michael L.;  Bridge, Tom C.;  Claar, Danielle C.;  Eakin, C. Mark;  Gilmour, James P.;  Graham, Nicholas A. J.;  Harrison, Hugo;  Hobbs, Jean-Paul A.;  Hoey, Andrew S.;  Hoogenboom, Mia;  Lowe, Ryan J.;  McCulloch, Malcolm T.;  Pandolfi, John M.;  Pratchett, Morgan;  Schoepf, Verena;  Torda, Gergely;  Wilson, Shaun K.
收藏  |  浏览/下载：10/0  |  提交时间：2019/11/27
Illuminating gravitational waves: A concordant picture of photons from a neutron star merger 期刊论文
SCIENCE, 2017, 358 (6370) : 1559-+
作者:  Kasliwal, M. M.;  Nakar, E.;  Singer, L. P.;  Kaplan, D. L.;  Cook, D. O.;  Van Sistine, A.;  Lau, R. M.;  Fremling, C.;  Gottlieb, O.;  Jencson, J. E.;  Adams, S. M.;  Feindt, U.;  Hotokezaka, K.;  Ghosh, S.;  Perley, D. A.;  Yu, P-C.;  Piran, T.;  Allison, J. R.;  Anupama, G. C.;  Balasubramanian, A.;  WBannister, K.;  Bally, J.;  Barnes, J.;  Barway, S.;  Bellm, E.;  Bhalerao, V.;  Bhattacharya, D.;  Blagorodnova, N.;  Bloom, J. S.;  Brady, P. R.;  Cannella, C.;  Chatterjee, D.;  Cenko, S. B.;  Cobb, B. E.;  Copperwheat, C.;  Corsi, A.;  De, K.;  Dobie, D.;  Emery, S. W. K.;  Evans, P. A.;  Fox, O. D.;  Frail, D. A.;  Frohmaier, C.;  Goobar, A.;  Hallinan, G.;  Harrison, F.;  Helou, G.;  Hinderer, T.;  Ho, A. Y. Q.;  Horesh, A.;  Ip, W-H.;  Itoh, R.;  Kasen, D.;  Kim, H.;  Kuin, N. P. M.;  Kupfer, T.;  Lynch, C.;  Madsen, K.;  Mazzali, P. A.;  Miller, A. A.;  Mooley, K.;  Murphy, T.;  Ngeow, C-C.;  Nichols, D.;  Nissanke, S.;  Nugent, P.;  Ofek, E. O.;  Qi, H.;  Quimby, R. M.;  Rosswog, S.;  Rusu, F.;  Sadler, E. M.;  Schmidt, P.;  Sollerman, J.;  Steele, I.;  Williamson, A. R.;  Xu, Y.;  Yan, L.;  Yatsu, Y.;  Zhang, C.;  Zhao, W.
收藏  |  浏览/下载：15/0  |  提交时间：2019/11/27
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution 期刊论文
NATURE, 2017, 545 (7655) : 446-+
作者:  Abbosh, Christopher;  Birkbak, Nicolai J.;  Wilson, Gareth A.;  Jamal-Hanjani, Mariam;  Constantin, Tudor;  Salari, Raheleh;  Le Quesne, John;  Moore, David A.;  Veeriah, Selvaraju;  Rosenthal, Rachel;  Marafioti, Teresa;  Kirkizlar, Eser;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Ward, Sophia;  Martinson, Luke;  Riley, Joan;  Fraioli, Francesco;  Al Bakir, Maise;  Gronroos, Eva;  Zambrana, Francisco;  Endozo, Raymondo;  Bi, Wenya Linda;  Fennessy, Fiona M.;  Sponer, Nicole;  Johnson, Diana;  Laycock, Joanne;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Rowan, Andrew;  Chambers, Tim;  Matthews, Nik;  Turajlic, Samra;  Hiley, Crispin;  Lee, Siow Ming;  Forster, Martin D.;  Ahmad, Tanya;  Falzon, Mary;  Borg, Elaine;  Lawrence, David;  Hayward, Martin;  Kolvekar, Shyam;  Panagiotopoulos, Nikolaos;  Janes, Sam M.;  Thakrar, Ricky;  Ahmed, Asia;  Blackhall, Fiona;  Summers, Yvonne;  Hafez, Dina;  Naik, Ashwini;  Ganguly, Apratim;  Kareht, Stephanie;  Shah, Rajesh;  Joseph, Leena;  Quinn, Anne Marie;  Crosbie, Phil A.;  Naidu, Babu;  Middleton, Gary;  Langman, Gerald;  Trotter, Simon;  Nicolson, Marianne;  Remmen, Hardy;  Kerr, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Fennell, Dean A.;  Nakas, Apostolos;  Rathinam, Sridhar;  Anand, Girija;  Khan, Sajid;  Russell, Peter;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Lester, Jason F.;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Adams, Haydn;  Davies, Helen;  Oukrif, Dahmane;  Akarca, Ayse U.;  Hartley, John A.;  Lowe, Helen L.;  Lock, Sara;  Iles, Natasha;  Bell, Harriet;  Ngai, Yenting;  Elgar, Greg;  Szallasi, Zoltan;  Schwarz, Roland F.;  Herrero, Javier;  Stewart, Aengus;  Quezada, Sergio A.;  Peggs, Karl S.;  Van Loo, Peter;  Dive, Caroline;  Lin, C. Jimmy;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Hackshaw, Allan;  Shaw, Jacqui A.;  Zimmermann, Bernhard G.;  Swanton, Charles;  Jamal-Hanjani, Mariam;  Abbosh, Christopher;  Veeriah, Selvaraju;  Shafi, Seema;  Czyzewska-Khan, Justyna;  Johnson, Diana;  Laycock, Joanne;  Bosshard-Carter, Leticia;  Goh, Gerald;  Rosenthal, Rachel;  Gorman, Pat;  Murugaesu, Nirupa;  Hynds, Robert E.;  Wilson, Gareth A.;  Birkbak, Nicolai J.;  Watkins, Thomas B. K.;  McGranahan, Nicholas;  Horswell, Stuart;  Al Bakir, Maise;  Gronroos, Eva;  Mitter, Richard;  Escudero, Mickael;  Stewart, Aengus;  Van Loo, Peter;  Rowan, Andrew;  Xu, Hang;  Turajlic, Samra;  Hiley, Crispin;  Goldman, Jacki;  Stone, Richard Kevin;  Denner, Tamara;  Matthews, Nik;  Elgar, Greg;  Ward, Sophia;  Biggs, Jennifer;  Costa, Marta;  Begum, Sharmin;  Phillimore, Ben;  Chambers, Tim;  Nye, Emma;  Graca, Sofia;  Joshi, Kroopa;  Furness, Andrew;  Ben Aissa, Assma;  Wong, Yien Ning Sophia;  Georgiou, Andy;  Quezada, Sergio A.;  Peggs, Karl S.;  Hartley, John A.;  Lowe, Helen L.;  Herrero, Javier;  Lawrence, David;  Hayward, Martin;  Panagiotopoulos, Nikolaos;  Kolvekar, Shyam;  Falzon, Mary;  Borg, Elaine;  Marafioti, Teresa;  Simeon, Celia;  Hector, Gemma;  Smith, Amy;  Aranda, Marie;  Novelli, Marco;  Oukrif, Dahmane;  Akarca, Ayse U.;  Janes, Sam M.;  Thakrar, Ricky;  Forster, Martin D.;  Ahmad, Tanya;  Lee, Siow Ming;  Papadatos-Pastos, Dionysis;  Carnell, Dawn;  Mendes, Ruheena;  George, Jeremy;  Navani, Neal;  Ahmed, Asia;  Taylor, Magali;  Choudhary, Junaid;  Summers, Yvonne;  Califano, Raffaele;  Taylor, Paul;  Shah, Rajesh;  Krysiak, Piotr;  Rammohan, Kendadai;  Fontaine, Eustace;  Booton, Richard;  Evison, Matthew;  Crosbie, Phil A.;  Moss, Stuart;  Idries, Faiza;  Joseph, Leena;  Bishop, Paul;  Chaturvedi, Anshuman;  Quinn, Anne Marie;  Doran, Helen;  Leek, Angela;  Harrison, Phil;  Moore, Katrina;  Waddington, Rachael;  Novasio, Juliette;  Blackhall, Fiona;  Rogan, Jane;  Smith, Elaine;  Dive, Caroline;  Tugwood, Jonathan;  Brady, Ged;  Rothwell, Dominic G.;  Chemi, Francesca;  Pierce, Jackie;  Gulati, Sakshi;  Naidu, Babu;  Langman, Gerald;  Trotter, Simon;  Bellamy, Mary;  Bancroft, Hollie;  Kerr, Amy;  Kadiri, Salma;  Webb, Joanne;  Middleton, Gary;  Djearaman, Madava;  Fennell, Dean A.;  Shaw, Jacqui A.;  Le Quesne, John;  Moore, David A.;  Thomas, Anne;  Walter, Harriet;  Riley, Joan;  Martinson, Luke;  Nakas, Apostolos;  Rathinam, Sridhar;  Monteiro, William;  Marshall, Hilary;  Nelson, Louise;  Bennett, Jonathan;  Primrose, Lindsay;  Anand, Girija;  Khan, Sajid;  Amadi, Anita;  Nicolson, Marianne;  Kerr, Keith;  Palmer, Shirley;  Remmen, Hardy;  Miller, Joy;  Buchan, Keith;  Chetty, Mahendran;  Gomersall, Lesley;  Lester, Jason F.;  Edwards, Alison;  Morgan, Fiona;  Adams, Haydn;  Davies, Helen;  Kornaszewska, Malgorzata;  Attanoos, Richard;  Lock, Sara;  Verjee, Azmina;  MacKenzie, Mairead;  Wilcox, Maggie;  Bell, Harriet;  Iles, Natasha;  Hackshaw, Allan;  Ngai, Yenting;  Smith, Sean;  Gower, Nicole;  Ottensmeier, Christian;  Chee, Serena;  Johnson, Benjamin;  Alzetani, Aiman;  Shaw, Emily;  Lim, Eric;  De Sousa, Paulo;  Barbosa, Monica Tavares;  Bowman, Alex;  Jordan, Simon;  Rice, Alexandra;  Raubenheimer, Hilgardt;  Proli, Chiara;  Cufari, Maria Elena;  Ronquillo, John Carlo;  Kwayie, Angela;  Bhayani, Harshil;  Hamilton, Morag;  Bakar, Yusura;  Mensah, Natalie;  Ambrose, Lyn;  Devaraj, Anand;  Buderi, Silviu;  Finch, Jonathan;  Azcarate, Leire;  Chavan, Hema;  Green, Sophie;  Mashinga, Hillaria;  Nicholson, Andrew G.;  Lau, Kelvin;  Sheaff, Michael;  Schmid, Peter;  Conibear, John;  Ezhil, Veni;  Ismail, Babikir;  Irvin-Sellers, Melanie;  Prakash, Vineet;  Russell, Peter;  Light, Teresa;  Horey, Tracey;  Danson, Sarah;  Bury, Jonathan;  Edwards, John;  Hill, Jennifer;  Matthews, Sue;  Kitsanta, Yota;  Suvarna, Kim;  Fisher, Patricia;  Keerio, Allah Dino;  Shackcloth, Michael;  Gosney, John;  Postmus, Pieter;  Feeney, Sarah;  Asante-Siaw, Julius;  Constantin, Tudor;  Salari, Raheleh;  Sponer, Nicole;  Naik, Ashwini;  Zimmermann, Bernhard G.;  Rabinowitz, Matthew;  Aerts, Hugo J. W. L.;  Dentro, Stefan;  Dessimoz, Christophe
收藏  |  浏览/下载：26/0  |  提交时间：2019/04/09
Global warming and recurrent mass bleaching of corals 期刊论文
NATURE, 2017, 543 (7645) : 373-+
作者:  Hughes, Terry P.;  Kerry, James T.;  Alvarez-Noriega, Mariana;  Alvarez-Romero, Jorge G.;  Anderson, Kristen D.;  Baird, Andrew H.;  Babcock, Russell C.;  Beger, Maria;  Bellwood, David R.;  Berkelmans, Ray;  Bridge, Tom C.;  Butler, Ian R.;  Byrne, Maria;  Cantin, Neal E.;  Comeau, Steeve;  Connolly, Sean R.;  Cumming, Graeme S.;  Dalton, Steven J.;  Diaz-Pulido, Guillermo;  Eakin, C. Mark;  Figueira, Will F.;  Gilmour, James P.;  Harrison, Hugo B.;  Heron, Scott F.;  Hoey, Andrew S.;  Hobbs, Jean-Paul A.;  Hoogenboom, Mia O.;  Kennedy, Emma V.;  Kuo, Chao-yang;  Lough, Janice M.;  Lowe, Ryan J.;  Liu, Gang;  Cculloch, Malcolm T. M.;  Malcolm, Hamish A.;  Mcwilliam, Michael J.;  Pandolfi, John M.;  Pears, Rachel J.;  Pratchett, Morgan S.;  Schoepf, Verena;  Simpson, Tristan;  Skirving, William J.;  Sommer, Brigitte;  Torda, Gergely;  Wachenfeld, David R.;  Willis, Bette L.;  Wilson, Shaun K.
收藏  |  浏览/下载：12/0  |  提交时间：2019/11/27