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Characteristics and origin of oil and gas in the Nanpu sag, Bohai Bay Basin, China: Insights from oil-source correlation and source rock effects 期刊论文
AAPG Bulletin, 2021
作者:  Gang Gao;  Jianyu Zhao;  Shangru Yang;  Wenzhe Gang;  Yuexia Dong;  Zhongxin Zhao
收藏  |  浏览/下载:11/0  |  提交时间:2021/07/27
New consideration of lateral boundary treatment for meso- and micro-scale nested PBL simulations over complex terrain 期刊论文
Atmospheric Research, 2021
作者:  Zihan Zhao, Yiqing Xiao, Chao Li, Jinghan Wang, Gang Hu
收藏  |  浏览/下载:9/0  |  提交时间:2021/02/17
Evidence for a serpentinized plate interface favouring continental subduction 期刊论文
NATURE COMMUNICATIONS, 2020, 11 (1)
作者:  Zhao, Liang;  Malusa, Marco G.;  Yuan, Huaiyu;  Paul, Anne;  Guillot, Stephane;  Lu, Yang;  Stehly, Laurent;  Solarino, Stefano;  Eva, Elena;  Lu, Gang;  Bodin, Thomas
收藏  |  浏览/下载:5/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
In situ vertical characteristics of optical properties and heating rates of aerosol over Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (4) : 2603-2622
作者:  Tian, Ping;  Liu, Dantong;  Zhao, Delong;  Yu, Chenjie;  Liu, Quan;  Huang, Mengyu;  Deng, Zhaoze;  Ran, Liang;  Wu, Yunfei;  Ding, Shuo;  Hu, Kang;  Zhao, Gang;  Zhao, Chunsheng;  Ding, Deping
收藏  |  浏览/下载:6/0  |  提交时间:2020/07/02
Distinct diurnal variation in organic aerosol hygroscopicity and its relationship with oxygenated organic aerosol 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 865-880
作者:  Kuang, Ye;  He, Yao;  Xu, Wanyun;  Zhao, Pusheng;  Cheng, Yafang;  Zhao, Gang;  Tao, Jiangchuan;  Ma, Nan;  Su, Hang;  Zhang, Yanyan;  Sun, Jiayin;  Cheng, Peng;  Yang, Wenda;  Zhang, Shaobin;  Wu, Cheng;  Sun, Yele;  Zhao, Chunsheng
收藏  |  浏览/下载:14/0  |  提交时间:2020/07/02
Role of black carbon mass size distribution in the direct aerosol radiative forcing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (20) : 13175-13188
作者:  Zhao, Gang;  Tao, Jiangchuan;  Kuang, Ye;  Shen, Chuanyang;  Yu, Yingli;  Zhao, Chunsheng
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
A new parameterization scheme for the real part of the ambient urban aerosol refractive index 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (20) : 12875-12885
作者:  Zhao, Gang;  Tan, Tianyi;  Zhao, Weilun;  Guo, Song;  Tian, Ping;  Zhao, Chunsheng
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
NH3-promoted hydrolysis of NO2 induces explosive growth in HONO 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (16) : 10557-10570
作者:  Xu, Wanyun;  Kuang, Ye;  Zhao, Chunsheng;  Tao, Jiangchuan;  Zhao, Gang;  Bian, Yuxuan;  Yang, Wen;  Yu, Yingli;  Shen, Chuanyang;  Liang, Linlin;  Zhang, Gen;  Lin, Weili;  Xu, Xiaobin
收藏  |  浏览/下载:8/0  |  提交时间:2019/11/27