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Reconstructing high-resolution temperature for the past 40 years in the Tianshan Mountains, China based on the Earth system data products 期刊论文
Atmospheric Research, 2021
作者:  Mengtian Fan, Jianhua Xu, Yaning Chen, Weihong Li
收藏  |  浏览/下载:5/0  |  提交时间:2021/02/17
A Middle Eocene lowland humid subtropical “Shangri-La” ecosystem in central Tibet 期刊论文
Proceedings of the National Academy of Science, 2020
作者:  Tao Su;  Robert A. Spicer;  Fei-Xiang Wu;  Alexander Farnsworth;  Jian Huang;  Cédric Del Rio;  Tao Deng;  Lin Ding;  Wei-Yu-Dong Deng;  Yong-Jiang Huang;  Alice Hughes;  Lin-Bo Jia;  Jian-Hua Jin;  Shu-Feng Li;  Shui-Qing Liang;  Jia Liu;  Xiao-Yan Liu;  Sarah Sherlock;  Teresa Spicer;  Gaurav Srivastava;  He Tang;  Paul Valdes;  Teng-Xiang Wang;  Mike Widdowson;  Meng-Xiao Wu;  Yao-Wu Xing;  Cong-Li Xu;  Jian Yang;  Cong Zhang;  Shi-Tao Zhang;  Xin-Wen Zhang;  Fan Zhao;  Zhe-Kun Zhou
收藏  |  浏览/下载:11/0  |  提交时间:2020/12/22
Characterization of submicron particles by time-of-flight aerosol chemical speciation monitor (ToF-ACSM) during wintertime: aerosol composition, sources, and chemical processes in Guangzhou, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7595-7615
作者:  Guo, Junchen;  Zhou, Shengzhen;  Cai, Mingfu;  Zhao, Jun;  Song, Wei;  Zhao, Weixiong;  Hu, Weiwei;  Sun, Yele;  He, Yao;  Yang, Chengqiang;  Xu, Xuezhe;  Zhang, Zhisheng;  Cheng, Peng;  Fan, Qi;  Hang, Jian;  Fan, Shaojia;  Wang, Xinming;  Wang, Xuemei
收藏  |  浏览/下载:19/0  |  提交时间:2020/07/06
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Strontium isotope stratigraphy and paleomagnetic age constraints on the evolution history of coral reef islands, northern South China Sea 期刊论文
GEOLOGICAL SOCIETY OF AMERICA BULLETIN, 2020, 132 (3-4) : 803-816
作者:  Fan, Tianlai;  Yu, Kefu;  Zhao, Jianxin;  Jiang, Wei;  Xu, Shendong;  Zhang, Yu;  Wang, Rui;  Wang, Yinghui;  Feng, Yuexing;  Bian, Lizeng;  Qian, Handong;  Liao, Weihua
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Contrasting size-resolved hygroscopicity of fine particles derived by HTDMA and HR-ToF-AMS measurements between summer and winter in Beijing: the impacts of aerosol aging and local emissions 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 915-929
作者:  Fan, Xinxin;  Liu, Jieyao;  Zhang, Fang;  Chen, Lu;  Collins, Don;  Xu, Weiqi;  Jin, Xiaoai;  Ren, Jingye;  Wang, Yuying;  Wu, Hao;  Li, Shangze;  Sun, Yele;  Li, Zhanqing
收藏  |  浏览/下载:8/0  |  提交时间:2020/07/02
Significant contribution of organics to aerosol liquid water content in winter in Beijing, China 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (2) : 901-914
作者:  Jin, Xiaoai;  Wang, Yuying;  Li, Zhanqing;  Zhang, Fang;  Xu, Weiqi;  Sun, Yele;  Fan, Xinxin;  Chen, Guangyu;  Wu, Hao;  Ren, Jingye;  Wang, Qiuyan;  Cribb, Maureen
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
Assessing progress towards sustainable development over space and time 期刊论文
NATURE, 2020, 577 (7788) : 74-+
作者:  Xu, Zhenci;  Chau, Sophia N.;  Chen, Xiuzhi;  Zhang, Jian;  Li, Yingjie;  Dietz, Thomas;  Wang, Jinyan;  Winkler, Julie A.;  Fan, Fan;  Huang, Baorong;  Li, Shuxin;  Wu, Shaohua;  Herzberger, Anna;  Tang, Ying;  Hong, Dequ;  Li, Yunkai;  Liu, Jianguo
收藏  |  浏览/下载:9/0  |  提交时间:2020/05/13

To address global challenges(1-4), 193 countries have committed to the 17 United Nations Sustainable Development Goals (SDGs)(5). Quantifying progress towards achieving the SDGs is essential to track global efforts towards sustainable development and guide policy development and implementation. However, systematic methods for assessing spatio-temporal progress towards achieving the SDGs are lacking. Here we develop and test systematic methods to quantify progress towards the 17 SDGs at national and subnational levels in China. Our analyses indicate that China'  s SDG Index score (an aggregate score representing the overall performance towards achieving all 17 SDGs) increased at the national level from 2000 to 2015. Every province also increased its SDG Index score over this period. There were large spatio-temporal variations across regions. For example, eastern China had a higher SDG Index score than western China in the 2000s, and southern China had a higher SDG Index score than northern China in 2015. At the national level, the scores of 13 of the 17 SDGs improved over time, but the scores of four SDGs declined. This study suggests the need to track the spatio-temporal dynamics of progress towards SDGs at the global level and in other nations.


  
Satellite testing of a gravitationally induced quantum decoherence model 期刊论文
SCIENCE, 2019, 366 (6461) : 132-+
作者:  Xu, Ping;  Ma, Yiqiu;  Ren, Ji-Gang;  Yong, Hai-Lin;  Ralph, Timothy C.;  Liao, Sheng-Kai;  Yin, Juan;  Liu, Wei-Yue;  Cai, Wen-Qi;  Han, Xuan;  Wu, Hui-Nan;  Wang, Wei-Yang;  Li, Feng-Zhi;  Yang, Meng;  Lin, Feng-Li;  Li, Li;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Chen, Yanbei;  Fan, Jingyun;  Peng, Cheng-Zhi;  Pan, Jian-Wei
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27