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A self-activating orphan receptor 期刊论文
NATURE, 2020, 579 (7797) : 35-35
作者:  Wang, Lin;  Wu, Juehui;  Li, Jun;  Yang, Hua;  Tang, Tianqi;  Liang, Haijiao;  Zuo, Mianyong;  Wang, Jie;  Liu, Haipeng;  Liu, Feng;  Chen, Jianxia;  Liu, Zhonghua;  Wang, Yang;  Peng, Cheng;  Wu, Xiangyang;  Zheng, Ruijuan;  Huang, Xiaochen;  Ran, Yajun;  Rao, Zihe;  Ge, Baoxue
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

The first 3D structure of a full-length G-protein-coupled receptor whose natural activator is unknown has been determined, providing insights into an unusual mode of activation and a basis for discovering therapeutics.


  
China takes centre stage in global biodiversity push 期刊论文
NATURE, 2020, 578 (7795) : 345-346
作者:  Wang, Lin;  Wu, Juehui;  Li, Jun;  Yang, Hua;  Tang, Tianqi;  Liang, Haijiao;  Zuo, Mianyong;  Wang, Jie;  Liu, Haipeng;  Liu, Feng;  Chen, Jianxia;  Liu, Zhonghua;  Wang, Yang;  Peng, Cheng;  Wu, Xiangyang;  Zheng, Ruijuan;  Huang, Xiaochen;  Ran, Yajun;  Rao, Zihe;  Ge, Baoxue
收藏  |  浏览/下载:18/0  |  提交时间:2020/07/03

A major United Nations summit could see China push for ambitious targets and spotlights the country'  s own conservation efforts.


A major United Nations summit could see China push for ambitious targets and spotlights the country'  s own conservation efforts.


  
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:143/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Shisa7 isa GABA(A) receptor auxiliary subunit controlling benzodiazepine actions 期刊论文
SCIENCE, 2019, 366 (6462) : 246-+
作者:  Han, Wenyan;  Li, Jun;  Pelkey, Kenneth A.;  Pandey, Saurabh;  Chen, Xiumin;  Wang, Ya-Xian;  Wu, Kunwei;  Ge, Lihao;  Li, Tianming;  Castellano, David;  Liu, Chengyu;  Wu, Ling-Gang;  Petralia, Ronald S.;  Lynch, Joseph W.;  McBain, Chris J.;  Lu, Wei
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis 期刊论文
SCIENCE, 2019, 364 (6443) : 851-+
作者:  Zhong, Sheng;  Liu, Meiling;  Wang, Zhijuan;  Huang, Qingpei;  Hou, Saiying;  Xu, Yong-Chao;  Ge, Zengxiang;  Song, Zihan;  Huang, Jiaying;  Qiu, Xinyu;  Shi, Yihao;  Xiao, Junyu;  Liu, Pei;  Guo, Ya-Long;  Dong, Juan;  Dresselhaus, Thomas;  Gu, Hongya;  Qu, Li-Jia
收藏  |  浏览/下载:17/0  |  提交时间:2019/11/27
Improved efficiency of the biological pump as a trigger for the Late Ordovician glaciation 期刊论文
NATURE GEOSCIENCE, 2018, 11 (7) : 510-+
作者:  Shen, Jiaheng;  Pearson, Ann;  Henkes, Gregory A.;  Zhang, Yi Ge;  Chen, Kefan;  Li, Dandan;  Wankel, Scott D.;  Finney, Stanley C.;  Shen, Yanan
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
A selfish genetic element confers non-Mendelian inheritance in rice 期刊论文
SCIENCE, 2018, 360 (6393) : 1130-1132
作者:  Yu, Xiaowen;  Zhao, Zhigang;  Zheng, Xiaoming;  Zhou, Jiawu;  Kong, Weiyi;  Wang, Peiran;  Bai, Wenting;  Zheng, Hai;  Zhang, Huan;  Li, Jing;  Liu, Jiafan;  Wang, Qiming;  Zhang, Long;  Liu, Kai;  Yu, Yang;  Guo, Xiuping;  Wang, Jiulin;  Lin, Qibing;  Wu, Fuqing;  Ren, Yulong;  Zhu, Shanshan;  Zhang, Xin;  Cheng, Zhijun;  Lei, Cailin;  Liu, Shijia;  Liu, Xi;  Tian, Yunlu;  Jiang, Ling;  Ge, Song;  Wu, Chuanyin;  Tao, Dayun;  Wang, Haiyang;  Wan, Jianmin
收藏  |  浏览/下载:20/0  |  提交时间:2019/11/27
Light matter interactions 期刊论文
SCIENCE, 2018, 360 (6389) : 30-34
作者:  Lu, Ling;  Liu, Rongjuan;  Xu, Xiulai;  Ge, Chen;  Jin, Kuijuan;  Wang, Li;  Yang, Guozhen
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
Arabidopsis pollen tube integrity and sperm release are regulated by RALF-mediated signaling 期刊论文
SCIENCE, 2017, 358 (6370) : 1596-1599
作者:  Ge, Zengxiang;  Bergonci, Tabata;  Zhao, Yuling;  Zou, Yanjiao;  Du, Shuo;  Liu, Ming-Che;  Luo, Xingju;  Ruan, Hao;  Garcia-Valencia, Liliana E.;  Zhong, Sheng;  Hou, Saiying;  Huang, Qingpei;  Lai, Luhua;  Moura, Daniel S.;  Gu, Hongya;  Dong, Juan;  Wu, Hen-Ming;  Dresselhaus, Thomas;  Xiao, Junyu;  Cheung, Alice Y.;  Qu, Li-Jia
收藏  |  浏览/下载:11/0  |  提交时间:2019/11/27
Satellite-based entanglement distribution over 1200 kilometers 期刊论文
SCIENCE, 2017, 356 (6343) : 1180-1184
作者:  Yin, Juan;  Cao, Yuan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Bo;  Dai, Hui;  Li, Guang-Bing;  Lu, Qi-Ming;  Gong, Yun-Hong;  Xu, Yu;  Li, Shuang-Lin;  Li, Feng-Zhi;  Yin, Ya-Yun;  Jiang, Zi-Qing;  Li, Ming;  Jia, Jian-Jun;  Ren, Ge;  He, Dong;  Zhou, Yi-Lin;  Zhang, Xiao-Xiang;  Wang, Na;  Chang, Xiang;  Zhu, Zhen-Cai;  Liu, Nai-Le;  Chen, Yu-Ao;  Lu, Chao-Yang;  Shu, Rong;  Peng, Cheng-Zhi;  Wang, Jian-Yu;  Pan, Jian-Wei
收藏  |  浏览/下载:18/0  |  提交时间:2019/11/27