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Experimental demonstration of memory-enhanced quantum communication 期刊论文
NATURE, 2020
作者:  Quinn, Robert A.;  Melnik, Alexey, V;  Vrbanac, Alison;  Fu, Ting;  Patras, Kathryn A.;  Christy, Mitchell P.;  Bodai, Zsolt;  Belda-Ferre, Pedro;  Tripathi, Anupriya;  Chung, Lawton K.;  Downes, Michael;  Welch, Ryan D.;  Quinn, Melissa;  Humphrey, Greg;  Panitchpakdi, Morgan;  Weldon, Kelly C.;  Aksenov, Alexander;  da Silva, Ricardo;  Avila-Pacheco, Julian;  Clish, Clary;  Bae, Sena;  Mallick, Himel;  Franzosa, Eric A.;  Lloyd-Price, Jason;  Bussell, Robert;  Thron, Taren;  Nelson, Andrew T.;  Wang, Mingxun;  Leszczynski, Eric;  Vargas, Fernando;  Gauglitz, Julia M.;  Meehan, Michael J.;  Gentry, Emily;  Arthur, Timothy D.;  Komor, Alexis C.;  Poulsen, Orit;  Boland, Brigid S.;  Chang, John T.;  Sandborn, William J.;  Lim, Meerana;  Garg, Neha;  Lumeng, Julie C.;  Xavier, Ramnik J.;  Kazmierczak, Barbara, I;  Jain, Ruchi;  Egan, Marie;  Rhee, Kyung E.;  Ferguson, David;  Raffatellu, Manuela;  Vlamakis, Hera;  Haddad, Gabriel G.;  Siegel, Dionicio;  Huttenhower, Curtis;  Mazmanian, Sarkis K.;  Evans, Ronald M.;  Nizet, Victor;  Knight, Rob;  Dorrestein, Pieter C.
收藏  |  浏览/下载:36/0  |  提交时间:2020/07/03

The ability to communicate quantum information over long distances is of central importance in quantum science and engineering(1). Although some applications of quantum communication such as secure quantum key distribution(2,3) are already being successfully deployed(4-7), their range is currently limited by photon losses and cannot be extended using straightforward measure-and-repeat strategies without compromising unconditional security(8). Alternatively, quantum repeaters(9), which utilize intermediate quantum memory nodes and error correction techniques, can extend the range of quantum channels. However, their implementation remains an outstanding challenge(10-16), requiring a combination of efficient and high-fidelity quantum memories, gate operations, and measurements. Here we use a single solid-state spin memory integrated in a nanophotonic diamond resonator(17-19) to implement asynchronous photonic Bell-state measurements, which are a key component of quantum repeaters. In a proof-of-principle experiment, we demonstrate high-fidelity operation that effectively enables quantum communication at a rate that surpasses the ideal loss-equivalent direct-transmission method while operating at megahertz clock speeds. These results represent a crucial step towards practical quantum repeaters and large-scale quantum networks(20,21).


A solid-state spin memory is used to demonstrate quantum repeater functionality, which has the potential to overcome photon losses involved in long-distance transmission of quantum information.


  
Mechanical regulation of glycolysis via cytoskeleton architecture 期刊论文
NATURE, 2020, 578 (7796) : 621-+
作者:  Faivre, Emily J.;  McDaniel, Keith F.;  Albert, Daniel H.;  Mantena, Srinivasa R.;  Plotnik, Joshua P.;  Wilcox, Denise;  Zhang, Lu;  Bui, Mai H.;  Sheppard, George S.;  Wang, Le;  Sehgal, Vasudha;  Lin, Xiaoyu;  Huang, Xiaoli;  Lu, Xin;  Uziel, Tamar;  Hessler, Paul;  Lam, Lloyd T.;  Bellin, Richard J.;  Mehta, Gaurav;  Fidanze, Steve;  Pratt, John K.;  Liu, Dachun;  Hasvold, Lisa A.;  Sun, Chaohong;  Panchal, Sanjay C.;  Nicolette, John J.;  Fossey, Stacey L.;  Park, Chang H.;  Longenecker, Kenton;  Bigelow, Lance;  Torrent, Maricel;  Rosenberg, Saul H.;  Kati, Warren M.;  Shen, Yu
收藏  |  浏览/下载:15/0  |  提交时间:2020/07/03

The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility(1-3). Although all of these processes consume energy(4,5), it is unknown whether and how cells adapt their metabolic activity to variable mechanical cues. Here we report that the transfer of human bronchial epithelial cells from stiff to soft substrates causes a downregulation of glycolysis via proteasomal degradation of the rate-limiting metabolic enzyme phosphofructokinase (PFK). PFK degradation is triggered by the disassembly of stress fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TRIM21). Transformed non-small-cell lung cancer cells, which maintain high glycolytic rates regardless of changing environmental mechanics, retain PFK expression by downregulating TRIM21, and by sequestering residual TRIM21 on a stress-fibre subset that is insensitive to substrate stiffness. Our data reveal a mechanism by which glycolysis responds to architectural features of the actomyosin cytoskeleton, thus coupling cell metabolism to the mechanical properties of the surrounding tissue. These processes enable normal cells to tune energy production in variable microenvironments, whereas the resistance of the cytoskeleton in response to mechanical cues enables the persistence of high glycolytic rates in cancer cells despite constant alterations of the tumour tissue.


Glycolysis in normal epithelial cells responds to microenvironmental mechanics via the modulation of actin bundles that sequester the phosphofructokinase-targeting ubiquitin ligase TRIM21, a process superseded by persistent actin bundles in cancer cells.


  
A proof of concept for structure-based vaccine design targeting RSV in humans 期刊论文
SCIENCE, 2019, 365 (6452) : 505-+
作者:  Crank, Michelle C.;  Ruckwardt, Tracy J.;  Chen, Man;  Morabito, Kaitlyn M.;  Phung, Emily;  Costner, Pamela J.;  Holman, LaSonji A.;  Hickman, Somia P.;  Berkowitz, Nina M.;  Gordon, Ingelise J.;  Yamshchikov, Galina V.;  Gaudinski, Martin R.;  Kumar, Azad;  Chang, Lauren A.;  Moin, Syed M.;  Hill, Juliane P.;  DiPiazza, Anthony T.;  Schwartz, Richard M.;  Kueltzo, Lisa;  Cooper, Jonathan W.;  Chen, Peifeng;  Stein, Judith A.;  Carlton, Kevin;  Gall, Jason G.;  Nason, Martha C.;  Kwong, Peter D.;  Chen, Grace L.;  Mascola, John R.;  McLellan, Jason S.;  Ledgerwood, Julie E.;  Graham, Barney S.
收藏  |  浏览/下载:10/0  |  提交时间:2019/11/27
Carbon dioxide sources from Alaska driven by increasing early winter respiration from Arctic tundra 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (21) : 5361-5366
作者:  Commane, Roisin;  Lindaas, Jakob;  Benmergui, Joshua;  Luus, Kristina A.;  Chang, Rachel Y. -W.;  Daube, Bruce C.;  Euskirchen, Eugenie S.;  Henderson, John M.;  Karion, Anna;  Miller, John B.;  Miller, Scot M.;  Parazoo, Nicholas C.;  Randerson, James T.;  Sweeney, Colm;  Tans, Pieter;  Thoning, Kirk;  Veraverbeke, Sander;  Miller, Charles E.;  Wofsy, Steven C.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27
carbon dioxide  Arctic  early winter respiration  Alaska  tundra  
Aging increases cell-to-cell transcriptional variability upon immune stimulation 期刊论文
SCIENCE, 2017, 355 (6332) : 1433-+
作者:  Martinez-Jimenez, Celia Pilar;  Eling, Nils;  Chen, Hung-Chang;  Vallejos, Catalina A.;  Kolodziejczyk, Aleksandra A.;  Connor, Frances;  Stojic, Lovorka;  Rayner, Timothy F.;  Stubbington, Michael J. T.;  Teichmann, Sarah A.;  de la Roche, Maike;  Marioni, John C.;  Odom, Duncan T.
收藏  |  浏览/下载:7/0  |  提交时间:2019/11/27