GSTDTAP

浏览/检索结果: 共13条,第1-10条 帮助

限定条件        
已选(0)清除 条数/页:   排序方式:
Mapping the drivers of formaldehyde (HCHO) variability from 2015-2019 over eastern China: insights from FTIR observation and GEOS-Chem model simulation 期刊论文
Atmospheric Chemistry and Physics, 2020
作者:  Youwen Sun, Hao Yin, Cheng Liu, Lin Zhang, Yuan Cheng, Mathias Palm, Justus Notholt, Xiao Lu, Corinne Vigouroux, Bo Zheng, Wei Wang, Nicholas Jones, Changong Shan, Yuan Tian, Qihou Hu, and Jianguo Liu
收藏  |  浏览/下载:44/0  |  提交时间:2020/08/09
Improved protein structure prediction using potentials from deep learning 期刊论文
NATURE, 2020, 577 (7792) : 706-+
作者:  Ma, Runze;  Cao, Duanyun;  Zhu, Chongqin;  Tian, Ye;  Peng, Jinbo;  Guo, Jing;  Chen, Ji;  Li, Xin-Zheng;  Francisco, Joseph S.;  Zeng, Xiao Cheng;  Xu, Li-Mei;  Wang, En-Ge;  Jiang, Ying
收藏  |  浏览/下载:143/0  |  提交时间:2020/07/03

Protein structure prediction can be used to determine the three-dimensional shape of a protein from its amino acid sequence(1). This problem is of fundamental importance as the structure of a protein largely determines its function(2)  however, protein structures can be difficult to determine experimentally. Considerable progress has recently been made by leveraging genetic information. It is possible to infer which amino acid residues are in contact by analysing covariation in homologous sequences, which aids in the prediction of protein structures(3). Here we show that we can train a neural network to make accurate predictions of the distances between pairs of residues, which convey more information about the structure than contact predictions. Using this information, we construct a potential of mean force(4) that can accurately describe the shape of a protein. We find that the resulting potential can be optimized by a simple gradient descent algorithm to generate structures without complex sampling procedures. The resulting system, named AlphaFold, achieves high accuracy, even for sequences with fewer homologous sequences. In the recent Critical Assessment of Protein Structure Prediction(5) (CASP13)-a blind assessment of the state of the field-AlphaFold created high-accuracy structures (with template modelling (TM) scores(6) of 0.7 or higher) for 24 out of 43 free modelling domains, whereas the next best method, which used sampling and contact information, achieved such accuracy for only 14 out of 43 domains. AlphaFold represents a considerable advance in protein-structure prediction. We expect this increased accuracy to enable insights into the function and malfunction of proteins, especially in cases for which no structures for homologous proteins have been experimentally determined(7).


  
Engineering bunched Pt-Ni alloy nanocages for efficient oxygen reduction in practical fuel cells 期刊论文
SCIENCE, 2019, 366 (6467) : 850-+
作者:  Tian, Xinlong;  Zhao, Xiao;  Su, Ya-Qiong;  Wang, Lijuan;  Wang, Hongming;  Dang, Dai;  Chi, Bin;  Liu, Hongfang;  Hensen, Emiel J. M.;  Lou, Xiong Wen (David);  Xia, Bao Yu
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
Evaluation of MODIS and two reanalysis aerosol optical depth products over AERONET sites 期刊论文
ATMOSPHERIC RESEARCH, 2019, 220: 75-80
作者:  Shi, Hanyu;  Xiao, Zhiciiang;  Zhan, Xuchen;  Ma, Han;  Tian, Xiaodan
收藏  |  浏览/下载:6/0  |  提交时间:2019/11/26
AERONET  AOD  Evaluation  MERRA  MODIS  
The Remote Responses of Early Summer Cold Vortex Precipitation in Northeastern China to the precedent Sea Surface Temperatures 期刊论文
ATMOSPHERIC RESEARCH, 2018, 214: 399-409
作者:  Fang, Yi-He;  Chen, Kai-Qi;  Chen, Hai-Shan;  Xu, Shi-Qi;  Geng, Xin;  Li, Tian-Yu;  Teng, Fang-Da;  Zhou, Xiao-Yu;  Wang, Yong-Guang
收藏  |  浏览/下载:9/0  |  提交时间:2019/04/09
NEC  Early summer northeast cold vortex precipitation  Ural Mountains'  blocking high  Sea of Okhotsk'  s blocking high  Lake Baikal'  s blocking high  North Atlantic SST tripole  Kuroshio SST  Model sensitivity tests  
East Asian dust storm in May 2017: observations, modelling, and its influence on the Asia-Pacific region 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2018, 18 (11) : 8353-8371
作者:  Zhang, Xiao-Xiao;  Sharratt, Brenton;  Liu, Lian-You;  Wang, Zi-Fa;  Pan, Xiao-Le;  Lei, Jia-Qiang;  Wu, Shi-Xin;  Huang, Shuang-Yan;  Guo, Yu-Hong;  Li, Jie;  Tang, Xiao;  Yang, Ting;  Tian, Yu;  Chen, Xue-Shun;  Hao, Jian-Qi;  Zheng, Hai-Tao;  Yang, Yan-Yan;  Lyu, Yan-Li
收藏  |  浏览/下载:12/0  |  提交时间:2019/04/09
A method for single-neuron chronic recording from the retina in awake mice 期刊论文
SCIENCE, 2018, 360 (6396) : 1447-+
作者:  Hong, Guosong;  Fu, Tian-Ming;  Qiao, Mu;  Viveros, Robert D.;  Yang, Xiao;  Zhou, Tao;  Lee, Jung Min;  Park, Hong-Gyu;  Sanes, Joshua R.;  Lieber, Charles M.
收藏  |  浏览/下载:5/0  |  提交时间:2019/11/27
Urbanization prolongs hantavirus epidemics in cities 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (18) : 4707-4712
作者:  Tian, Huaiyu;  Hu, Shixiong;  Cazelles, Bernard;  Chowell, Gerardo;  Gao, Lidong;  Laine, Marko;  Li, Yapin;  Yang, Huisuo;  Li, Yidan;  Yang, Qiqi;  Tong, Xin;  Huang, Ru;  Bjornstad, Otter N.;  Xiao, Hong;  Stenseth, Nils Chr.
收藏  |  浏览/下载:13/0  |  提交时间:2019/11/27
urbanization  immigration  hantavirus  endemic turning point  China  
The evolutionary history of vertebrate RNA viruses 期刊论文
NATURE, 2018, 556 (7700) : 197-+
作者:  Shi, Mang;  Lin, Xian-Dan;  Chen, Xiao;  Tian, Jun-Hua;  Chen, Liang-Jun;  Li, Kun;  Wang, Wen;  Eden, John-Sebastian;  Shen, Jin-Jin;  Liu, Li;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:14/0  |  提交时间:2019/11/27
Health effects of banning beehive coke ovens and implementation of the ban in China 期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (11) : 2693-2698
作者:  Xu, Yang;  Shen, Huizhong;  Yun, Xiao;  Gao, Fei;  Chen, Yilin;  Li, Bengang;  Liu, Junfeng;  Ma, Jianmin;  Wang, Xilong;  Liu, Xueping;  Tian, Chongguo;  Xing, Baoshan;  Tao, Shu
收藏  |  浏览/下载:9/0  |  提交时间:2019/11/27
beehive coke oven  lung cancer risk  benzo[a]pyrene  ban  law implementation