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Differentiation Between Nitrate Aerosol Formation Pathways in a Southeast Chinese City by Dual Isotope and Modeling Studies 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (13)
作者:  Xiao, Hong-Wei;  Zhu, Ren-Guo;  Pan, Yuan-Yuan;  Guo, Wei;  Zheng, Neng-Jian;  Liu, Yong-Hui;  Liu, Cheng;  Zhang, Zhong-Yi;  Wu, Jing-Feng;  Kang, Chang-An;  Luo, Li;  Xiao, Hua-Yun
收藏  |  浏览/下载:19/0  |  提交时间:2020/08/18
Decadal changes in anthropogenic source contribution of PM2.5 pollution and related health impacts in China, 1990-2015 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (13) : 7783-7799
作者:  Liu, Jun;  Zheng, Yixuan;  Geng, Guannan;  Hong, Chaopeng;  Li, Meng;  Li, Xin;  Liu, Fei;  Tong, Dan;  Wu, Ruili;  Zheng, Bo;  He, Kebin;  Zhang, Qiang
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/06
Retrospect driving forces and forecasting reduction potentials of energy-related industrial carbon emissions from China's manufacturing at city level 期刊论文
ENVIRONMENTAL RESEARCH LETTERS, 2020, 15 (7)
作者:  Su, Yongxian;  Wang, Yilong;  Zheng, Bo;  Ciais, Philippe;  Wu, Jianping;  Chen, Xiuzhi;  Wang, Yang;  Wang, Changjian;  Ye, Yuyao;  Li, Qian;  Zhang, Chaoqun;  Zhang, Hongou;  Huang, Guangqing;  Huang, Ningsheng;  Lafortezza, Raffaele
收藏  |  浏览/下载:13/0  |  提交时间:2020/08/18
carbon emission mitigation  city level  manufacturing  scenario design  carbon emission driver  mitigation strategy  
WHY HEALTHY ARTERIES MIGHT HELP KIDS AVOID COVID COMPLICATIONS 期刊论文
NATURE, 2020, 582 (7812) : 324-325
作者:  Niu, Jixiao;  Sun, Yang;  Chen, Baoen;  Zheng, Baohui;  Jarugumilli, Gopala K.;  Walker, Sarah R.;  Hata, Aaron N.;  Mino-Kenudson, Mari;  Frank, David A.;  Wu, Xu
收藏  |  浏览/下载:17/0  |  提交时间:2020/07/03
A developmental landscape of 3D-cultured human pre-gastrulation embryos 期刊论文
NATURE, 2020, 577 (7791) : 537-+
作者:  Xiang, Lifeng;  Yin, Yu;  Zheng, Yun;  Ma, Yanping;  Li, Yonggang;  Zhao, Zhigang;  Guo, Junqiang;  Ai, Zongyong;  Niu, Yuyu;  Duan, Kui;  He, Jingjing;  Ren, Shuchao;  Wu, Dan;  Bai, Yun;  Shang, Zhouchun;  Dai, Xi;  Ji, Weizhi;  Li, Tianqing
收藏  |  浏览/下载:12/0  |  提交时间:2020/07/03

Our understanding of how human embryos develop before gastrulation, including spatial self-organization and cell type ontogeny, remains limited by available two-dimensional technological platforms(1,2) that do not recapitulate the in vivo conditions(3-5). Here we report a three-dimensional (3D) blastocyst-culture system that enables human blastocyst development up to the primitive streak anlage stage. These 3D embryos mimic developmental landmarks and 3D architectures in vivo, including the embryonic disc, amnion, basement membrane, primary and primate unique secondary yolk sac, formation of anterior-posterior polarity and primitive streak anlage. Using single-cell transcriptome profiling, we delineate ontology and regulatory networks that underlie the segregation of epiblast, primitive endoderm and trophoblast. Compared with epiblasts, the amniotic epithelium shows unique and characteristic phenotypes. After implantation, specific pathways and transcription factors trigger the differentiation of cytotrophoblasts, extravillous cytotrophoblasts and syncytiotrophoblasts. Epiblasts undergo a transition to pluripotency upon implantation, and the transcriptome of these cells is maintained until the generation of the primitive streak anlage. These developmental processes are driven by different pluripotency factors. Together, findings from our 3D-culture approach help to determine the molecular and morphogenetic developmental landscape that occurs during human embryogenesis.


A 3D culture system to model human embryonic development, together with single-cell transcriptome profiling, provides insights into the molecular developmental landscape during human post-implantation embryogenesis.


  
Characteristics of the Prolonged El Nino Events During 1960-2020 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (12)
作者:  Lee, Chung-Wei;  Tseng, Yu-Heng;  Sui, Chung-Hsiung;  Zheng, Fei;  Wu, Erh-Tung
收藏  |  浏览/下载:8/0  |  提交时间:2020/05/25
Sustainable production of value-added carbon nanomaterials from biomass pyrolysis 期刊论文
NATURE SUSTAINABILITY, 2020
作者:  Zhang, Shun;  Jiang, Shun-Feng;  Huang, Bao-Cheng;  Shen, Xian-Cheng;  Chen, Wen-Jing;  Zhou, Tian-Pei;  Cheng, Hui-Yuan;  Cheng, Bin-Hai;  Wu, Chang-Zheng;  Li, Wen-Wei;  Jiang, Hong;  Yu, Han-Qing
收藏  |  浏览/下载:20/0  |  提交时间:2020/05/20
A neurotransmitter produced by gut bacteria modulates host sensory behaviour 期刊论文
NATURE, 2020
作者:  Zhao, Xiaoxu;  Song, Peng;  Wang, Chengcai;  Riis-Jensen, Anders C.;  Fu, Wei;  Deng, Ya;  Wan, Dongyang;  Kang, Lixing;  Ning, Shoucong;  Dan, Jiadong;  Venkatesan, T.;  Liu, Zheng;  Zhou, Wu;  Thygesen, Kristian S.;  Luo, Xin;  Pennycook, Stephen J.;  Loh, Kian Ping
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/03

A neuromodulator produced by commensalProvidenciabacteria that colonize the gut ofCaenorhabditis elegansmimics the functions of the cognate host molecule to manipulate a sensory decision of the host.


Animals coexist in commensal, pathogenic or mutualistic relationships with complex communities of diverse organisms, including microorganisms(1). Some bacteria produce bioactive neurotransmitters that have previously been proposed to modulate nervous system activity and behaviours of their hosts(2,3). However, the mechanistic basis of this microbiota-brain signalling and its physiological relevance are largely unknown. Here we show that inCaenorhabditis elegans, the neuromodulator tyramine produced by commensalProvidenciabacteria, which colonize the gut, bypasses the requirement for host tyramine biosynthesis and manipulates a host sensory decision. Bacterially produced tyramine is probably converted to octopamine by the host tyramine beta-hydroxylase enzyme. Octopamine, in turn, targets the OCTR-1 octopamine receptor on ASH nociceptive neurons to modulate an aversive olfactory response. We identify the genes that are required for tyramine biosynthesis inProvidencia, and show that these genes are necessary for the modulation of host behaviour. We further find thatC. eleganscolonized byProvidenciapreferentially select these bacteria in food choice assays, and that this selection bias requires bacterially produced tyramine and host octopamine signalling. Our results demonstrate that a neurotransmitter produced by gut bacteria mimics the functions of the cognate host molecule to override host control of a sensory decision, and thereby promotes fitness of both the host and the microorganism.


  
CO Emissions Inferred From Surface CO Observations Over China in December 2013 and 2017 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (7)
作者:  Feng, Shuzhuang;  Jiang, Fei;  Wu, Zheng;  Wang, Hengmao;  Ju, Weimin;  Wang, Haikun
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
EnKF data assimilation  CO emission  inversion  WRF  CMAQ model  emission changes  
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.