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The Potential Impact of Nuclear Conflict on Ocean Acidification 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2020, 47 (3)
作者:  Lovenduski, Nicole S.;  Harrison, Cheryl S.;  Olivarez, Holly;  Bardeen, Charles;  Toon, Owen B.;  Coupe, Joshua;  Robock, Alan;  Rohr, Tyler;  Stevenson, Samantha
收藏  |  浏览/下载：6/0  |  提交时间：2020/07/02
A mycobacterial ABC transporter mediates the uptake of hydrophilic compounds 期刊论文
NATURE, 2020, 580 (7803) : 409-+
作者:  Al-Shayeb, Basem;  Sachdeva, Rohan;  Chen, Lin-Xing;  Ward, Fred;  Munk, Patrick;  Devoto, Audra;  Castelle, Cindy J.;  Olm, Matthew R.;  Bouma-Gregson, Keith;  Amano, Yuki;  He, Christine;  Meheust, Raphael;  Brooks, Brandon;  Thomas, Alex;  Levy, Adi;  Matheus-Carnevali, Paula;  Sun, Christine;  Goltsman, Daniela S. A.;  Borton, Mikayla A.;  Sharrar, Allison;  Jaffe, Alexander L.;  Nelson, Tara C.;  Kantor, Rose;  Keren, Ray;  Lane, Katherine R.;  Farag, Ibrahim F.;  Lei, Shufei;  Finstad, Kari;  Amundson, Ronald;  Anantharaman, Karthik;  Zhou, Jinglie;  Probst, Alexander J.;  Power, Mary E.;  Tringe, Susannah G.;  Li, Wen-Jun;  Wrighton, Kelly;  Harrison, Sue;  Morowitz, Michael;  Relman, David A.;  Doudna, Jennifer A.;  Lehours, Anne-Catherine;  Warren, Lesley;  Cate, Jamie H. D.;  Santini, Joanne M.;  Banfield, Jillian F.
收藏  |  浏览/下载：34/0  |  提交时间：2020/07/03

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen and the causative agent of tuberculosis(1-3). Although Mtb can synthesize vitamin B-12 (cobalamin) de novo, uptake of cobalamin has been linked to pathogenesis of tuberculosis2. Mtb does not encode any characterized cobalamin transporter(4-6)  however, the gene rv1819c was found to be essential for uptake of cobalamin(1). This result is difficult to reconcile with the original annotation of Rv1819c as a protein implicated in the transport of antimicrobial peptides such as bleomycin(7). In addition, uptake of cobalamin seems inconsistent with the amino acid sequence, which suggests that Rv1819c has a bacterial ATP-binding cassette (ABC)-exporter fold1. Here, we present structures of Rv1819c, which reveal that the protein indeed contains the ABC-exporter fold, as well as a large water-filled cavity of about 7,700 angstrom(3), which enables the protein to transport the unrelated hydrophilic compounds bleomycin and cobalamin. On the basis of these structures, we propose that Rv1819c is a multi-solute transporter for hydrophilic molecules, analogous to the multidrug exporters of the ABC transporter family, which pump out structurally diverse hydrophobic compounds from cells(8-11).


  
Observations of highly oxidized molecules and particle nucleation in the atmosphere of Beijing 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (23) : 14933-14947
作者:  Brean, James;  Harrison, Roy M.;  Shi, Zongbo;  Beddows, David C. S.;  Acton, W. Joe F.;  Hewitt, C. Nicholas;  Squires, Freya A.;  Lee, James
收藏  |  浏览/下载：9/0  |  提交时间：2020/02/17
A chemo-enzymatic oxidation cascade to activate C-H bonds with in situ generated H2O2 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Freakley, Simon J.;  Kochius, Svenja;  van Marwijk, Jacqueline;  Fenner, Caryn;  Lewis, Richard J.;  Baldenius, Kai;  Marais, Sarel S.;  Opperman, Diederik J.;  Harrison, Susan T. L.;  Alcalde, Miguel;  Smit, Martha S.;  Hutchings, Graham J.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/27
Phase stabilization by electronic entropy in plutonium 期刊论文
NATURE COMMUNICATIONS, 2019, 10
作者:  Harrison, N.;  Betts, J. B.;  Wartenbe, M. R.;  Balakirev, F. F.;  Richmond, S.;  Jaime, M.;  Tobash, P. N.
收藏  |  浏览/下载：0/0  |  提交时间：2019/11/27
Translating Marine Animal Tracking Data into Conservation Policy and Management 期刊论文
TRENDS IN ECOLOGY & EVOLUTION, 2019, 34 (5) : 459-473
作者:  Hays, Graeme C.;  Bailey, Helen;  Bograd, Steven J.;  Bowen, W. Don;  Campagna, Claudio;  Carmichael, Ruth H.;  Casale, Paolo;  Chiaradia, Andre;  Costa, Daniel P.;  Cuevas, Eduardo;  de Bruyn, P. J. Nico;  Dias, Maria P.;  Duarte, Carlos M.;  Dunn, Daniel C.;  Dutton, Peter H.;  Esteban, Nicole;  Friedlaender, Ari;  Goetz, Kimberly T.;  Godley, Brendan J.;  Halpin, Patrick N.;  Hamann, Mark;  Hammerschlag, Neil;  Harcourt, Robert;  Harrison, Autumn-Lynn;  Hazen, Elliott L.;  Heupel, Michelle R.;  Hoyt, Erich;  Humphries, Nicolas E.;  Kot, Connie Y.;  Lea, James S. E.;  Marsh, Helene;  Maxwell, Sara M.;  McMahon, Clive R.;  di Sciara, Giuseppe Notarbartolo;  Palacios, Daniel M.;  Phillips, Richard A.;  Righton, David;  Schofield, Gail;  Seminoff, Jeffrey A.;  Simpfendorfer, Colin A.;  Sims, David W.;  Takahashi, Akinori;  Tetley, Michael J.;  Thums, Michele;  Trathan, Philip N.;  Villegas-Amtmann, Stella;  Wells, Randall S.;  Whiting, Scott D.;  Wildermann, Natalie E.;  Msequeira, Ana M. M.
收藏  |  浏览/下载：13/0  |  提交时间：2019/11/26
Meteorological Source Variability in Atmospheric Gravity Wave Parameters Derived From a Tropical Infrasound Station 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (8) : 4352-4364
作者:  Marlton, G. J.;  Charlton-Perez, A. J.;  Harrison, R. G.;  Blanc, E.;  Evers, L.;  Le-Pichon, A.;  Smets, P. S. M.
收藏  |  浏览/下载：8/0  |  提交时间：2019/11/26
Receptor modelling of both particle composition and size distribution from a background site in London, UK - a two-step approach 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (7) : 4863-4876
作者:  Beddows, David C. S.;  Harrison, Roy M.
收藏  |  浏览/下载：6/0  |  提交时间：2019/11/26
Impacts of timber harvest intensity and P fertilizer application on soil P fractions 期刊论文
FOREST ECOLOGY AND MANAGEMENT, 2019, 437: 295-303
作者:  Rocha, Jose Henrique T.;  Menegale, Marcella L. C.;  Rodrigues, Marcos;  Goncalves, Jose Leonardo de M.;  Pavinato, Paulo S.;  Foltran, Estela Couvre;  Harrison, Robert;  James, Jason N.
收藏  |  浏览/下载：7/0  |  提交时间：2019/04/09
Phosphorus fractionation  Forest residue management  Eucalyptus grandis  P availability  Minimum tillage  
Aliphatic carbonyl compounds (C-8-C-26) in wintertime atmospheric aerosol in London, UK 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2019, 19 (4) : 2233-2246
作者:  Lyu, Ruihe;  Alam, Mohammed S.;  Stark, Christopher;  Xu, Ruixin;  Shi, Zongbo;  Feng, Yinchang;  Harrison, Roy M.
收藏  |  浏览/下载：10/0  |  提交时间：2019/04/09