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Economics in the Age of COVID-19 期刊论文
NATURE, 2020, 581 (7809) : 375-377
作者:  Yin, Juan;  Li, Yu-Huai;  Liao, Sheng-Kai;  Yang, Meng;  Cao, Yuan;  Zhang, Liang;  Ren, Ji-Gang;  Cai, Wen-Qi;  Liu, Wei-Yue;  Li, Shuang-Lin;  Shu, Rong;  Huang, Yong-Mei;  Deng, Lei;  Li, Li;  Zhang, Qiang;  Liu, Nai-Le
收藏  |  浏览/下载:25/0  |  提交时间:2020/07/03

Breakneck triage nails many diagnoses, but deeper treatment is needed.


Breakneck triage nails many diagnoses, but deeper treatment is needed.


  
Dynamic spatial-temporal precipitation distribution models for short-duration rainstorms in Shenzhen, China based on machine learning 期刊论文
ATMOSPHERIC RESEARCH, 2020, 237
作者:  Liu, Yuan-Yuan;  Li, Lei;  Liu, Ye-Sen;  Chan, Pak Wai;  Zhang, Wen-Hai
收藏  |  浏览/下载:9/0  |  提交时间:2020/07/02
Short-duration rainstorm  Machine learning  Locally linear embedding method  Dynamic spatial-temporal distribution  Shenzhen  
Significant methane ebullition from alpine permafrost rivers on the East Qinghai-Tibet Plateau 期刊论文
NATURE GEOSCIENCE, 2020, 13 (5)
作者:  Zhang, Liwei;  Xia, Xinghui;  Liu, Shaoda;  Zhang, Sibo;  Li, Siling;  Wang, Junfeng;  Wang, Gongqin;  Gao, Hui;  Zhang, Zhenrui;  Wang, Qingrui;  Wen, Wu;  Liu, Ran;  Yang, Zhifeng;  Stanley, Emily H.;  Raymond, Peter A.
收藏  |  浏览/下载:11/0  |  提交时间:2020/05/13
Structure and mechanism of human diacylglycerol O-acyltransferase 1 期刊论文
NATURE, 2020, 581 (7808) : 329-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:24/0  |  提交时间:2020/07/03

The structure of human diacylglycerol O-acyltransferase 1, a membrane protein that synthesizes triacylglycerides, is solved with cryo-electron microscopy, providing insight into its function and mechanism of enzymatic activity.


Diacylglycerol O-acyltransferase 1 (DGAT1) synthesizes triacylglycerides and is required for dietary fat absorption and fat storage in humans(1). DGAT1 belongs to the membrane-bound O-acyltransferase (MBOAT) superfamily, members of which are found in all kingdoms of life and are involved in the acylation of lipids and proteins(2,3). How human DGAT1 and other mammalian members of the MBOAT family recognize their substrates and catalyse their reactions is unknown. The absence of three-dimensional structures also hampers rational targeting of DGAT1 for therapeutic purposes. Here we present the cryo-electron microscopy structure of human DGAT1 in complex with an oleoyl-CoA substrate. Each DGAT1 protomer has nine transmembrane helices, eight of which form a conserved structural fold that we name the MBOAT fold. The MBOAT fold in DGAT1 forms a hollow chamber in the membrane that encloses highly conserved catalytic residues. The chamber has separate entrances for each of the two substrates, fatty acyl-CoA and diacylglycerol. DGAT1 can exist as either a homodimer or a homotetramer and the two forms have similar enzymatic activity. The N terminus of DGAT1 interacts with the neighbouring protomer and these interactions are required for enzymatic activity.


  
The online competition between pro- and anti-vaccination views 期刊论文
NATURE, 2020, 582 (7811) : 230-+
作者:  Wu, Fan;  Zhao, Su;  Yu, Bin;  Chen, Yan-Mei;  Wang, Wen;  Song, Zhi-Gang;  Hu, Yi;  Tao, Zhao-Wu;  Tian, Jun-Hua;  Pei, Yuan-Yuan;  Yuan, Ming-Li;  Zhang, Yu-Ling;  Dai, Fa-Hui;  Liu, Yi;  Wang, Qi-Min;  Zheng, Jiao-Jiao;  Xu, Lin;  Holmes, Edward C.;  Zhang, Yong-Zhen
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/03

Insights into the interactions between pro- and anti-vaccination clusters on Facebook can enable policies and approaches that attempt to interrupt the shift to anti-vaccination views and persuade undecided individuals to adopt a pro-vaccination stance.


Distrust in scientific expertise(1-14) is dangerous. Opposition to vaccination with a future vaccine against SARS-CoV-2, the causal agent of COVID-19, for example, could amplify outbreaks(2-4), as happened for measles in 2019(5,6). Homemade remedies(7,8) and falsehoods are being shared widely on the Internet, as well as dismissals of expert advice(9-11). There is a lack of understanding about how this distrust evolves at the system level(13,14). Here we provide a map of the contention surrounding vaccines that has emerged from the global pool of around three billion Facebook users. Its core reveals a multi-sided landscape of unprecedented intricacy that involves nearly 100 million individuals partitioned into highly dynamic, interconnected clusters across cities, countries, continents and languages. Although smaller in overall size, anti-vaccination clusters manage to become highly entangled with undecided clusters in the main online network, whereas pro-vaccination clusters are more peripheral. Our theoretical framework reproduces the recent explosive growth in anti-vaccination views, and predicts that these views will dominate in a decade. Insights provided by this framework can inform new policies and approaches to interrupt this shift to negative views. Our results challenge the conventional thinking about undecided individuals in issues of contention surrounding health, shed light on other issues of contention such as climate change(11), and highlight the key role of network cluster dynamics in multi-species ecologies(15).


  
Terrestrial CO2 Fluxes, Concentrations, Sources and Budget in Northeast China: Observational and Modeling Studies 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (6)
作者:  Li, Xiaolan;  Hu, Xiao-Ming;  Cai, Changjie;  Jia, Qingyu;  Zhang, Yao;  Liu, Jingmiao;  Xue, Ming;  Xu, Jianming;  Wen, Rihong;  Crowell, Sean M. R.
收藏  |  浏览/下载:10/0  |  提交时间:2020/07/02
Radar Reflectivity of Lightning Flashes in Stratiform Regions of Mesoscale Convective Systems 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (24) : 14114-14132
作者:  Wang, Fei;  Liu, Hengyi;  Dong, Wansheng;  Zhang, Yijun;  Yao, Wen;  Zheng, Dong
收藏  |  浏览/下载:11/0  |  提交时间:2020/02/17
lightning flash initiation  stratiform regions  mesoscale convective systems  reflectivity  bright band  in situ electrification  
Engineering bunched Pt-Ni alloy nanocages for efficient oxygen reduction in practical fuel cells 期刊论文
SCIENCE, 2019, 366 (6467) : 850-+
作者:  Tian, Xinlong;  Zhao, Xiao;  Su, Ya-Qiong;  Wang, Lijuan;  Wang, Hongming;  Dang, Dai;  Chi, Bin;  Liu, Hongfang;  Hensen, Emiel J. M.;  Lou, Xiong Wen (David);  Xia, Bao Yu
收藏  |  浏览/下载:9/0  |  提交时间:2020/02/17
Relationship between the South China Sea summer monsoon withdrawal and September-October rainfall over southern China 期刊论文
CLIMATE DYNAMICS, 2019
作者:  Hu, Peng;  Chen, Wen;  Chen, Shangfeng;  Liu, Yuyun;  Huang, Ruping;  Dong, Shaorou
收藏  |  浏览/下载:6/0  |  提交时间:2020/02/17
South China Sea  Summer monsoon withdrawal  Rainfall  Southern China  Tropical cyclone  Interannual variability  
Increased high-latitude photosynthetic carbon gain offset by respiration carbon loss during an anomalous warm winter to spring transition 期刊论文
GLOBAL CHANGE BIOLOGY, 2019
作者:  Liu, Zhihua;  Kimball, John S.;  Parazoo, Nicholas C.;  Ballantyne, Ashley P.;  Wang, Wen J.;  Madani, Nima;  Pan, Caleb G.;  Watts, Jennifer D.;  Reichle, Rolf H.;  Sonnentag, Oliver;  Marsh, Philip;  Hurkuck, Miriam;  Helbig, Manuel;  Quinton, William L.;  Zona, Donatella;  Ueyama, Masahito;  Kobayashi, Hideki;  Euskirchen, Eugenie S.
收藏  |  浏览/下载:12/0  |  提交时间:2019/11/27
ABoVE  boreal  carbon cycle  climate change  productivity  respiration  SMAP L4C  soil moisture  tundra