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Enhanced growth rate of atmospheric particles from sulfuric acid 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (12) : 7359-7372
作者:  Stolzenburg, Dominik;  Simon, Mario;  Ranjithkumar, Ananth;  Kuerten, Andreas;  Lehtipalo, Katrianne;  Gordon, Hamish;  Ehrhart, Sebastian;  Finkenzeller, Henning;  Pichelstorfer, Lukas;  Nieminen, Tuomo;  He, Xu-Cheng;  Brilke, Sophia;  Xiao, Mao;  Amorim, Antonio;  Baalbaki, Rima;  Baccarini, Andrea;  Beck, Lisa;  Brakling, Steffen;  Murillo, Lucia Caudillo;  Chen, Dexian;  Chu, Biwu;  Dada, Lubna;  Dias, Antonio;  Dommen, Josef;  Duplissy, Jonathan;  El Haddad, Imad;  Fischer, Lukas;  Carracedo, Loic Gonzalez;  Heinritzi, Martin;  Kim, Changhyuk;  Koenig, Theodore K.;  Kong, Weimeng;  Lamkaddam, Houssni;  Lee, Chuan Ping;  Leiminger, Markus;  Li, Zijun;  Makhmutov, Vladimir;  Manninen, Hanna E.;  Marie, Guillaume;  Marten, Ruby;  Mueller, Tatjana;  Nie, Wei;  Partoll, Eva;  Petaja, Tuukka;  Pfeifer, Joschka;  Philippov, Maxim;  Rissanen, Matti P.;  Rorup, Birte;  Schobesberger, Siegfried;  Schuchmann, Simone;  Shen, Jiali;  Sipila, Mikko;  Steiner, Gerhard;  Stozhkov, Yuri;  Tauber, Christian;  Tham, Yee Jun;  Tome, Antonio;  Vazquez-Pufleau, Miguel;  Wagner, Andrea C.;  Wang, Mingyi;  Wang, Yonghong;  Weber, Stefan K.;  Wimmer, Daniela;  Wlasits, Peter J.;  Wu, Yusheng;  Ye, Qing;  Zauner-Wieczorek, Marcel;  Baltensperger, Urs;  Carslaw, Kenneth S.;  Curtius, Joachim;  Donahue, Neil M.;  Flagan, Richard C.;  Hansel, Armin;  Kulmala, Markku;  Lelieveld, Jos;  Volkamer, Rainer;  Kirkby, Jasper;  Winkler, Paul M.
收藏  |  浏览/下载：25/0  |  提交时间：2020/08/18
Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation 期刊论文
NATURE, 2020, 580 (7803) : 391-+
作者:  Zhang, Zhibin;  Zhang, Ying;  Xia, Shiyu;  Kong, Qing;  Li, Shunying;  Liu, Xing;  Junqueira, Caroline;  Meza-Sosa, Karla F.;  Mok, Temy Mo Yin;  Ansara, James;  Sengupta, Satyaki;  Yao, Yandan;  Wu, Hao;  Lieberman, Judy
收藏  |  浏览/下载：12/0  |  提交时间：2020/07/03

The biological function of Z-DNA and Z-RNA, nucleic acid structures with a left-handed double helix, is poorly understood(1-3). Z-DNA-binding protein 1 (ZBP1  also known as DAI or DLM-1) is a nucleic acid sensor that contains two Z alpha domains that bind Z-DNA(4,5) and Z-RNA(6-8). ZBP1 mediates host defence against some viruses(6,7,9-14) by sensing viral nucleic acids(6,7,10). RIPK1 deficiency, or mutation of its RIP homotypic interaction motif (RHIM), triggers ZBP1-dependent necroptosis and inflammation in mice(15,16). However, the mechanisms that induce ZBP1 activation in the absence of viral infection remain unknown. Here we show that Z alpha-dependent sensing of endogenous ligands induces ZBP1-mediated perinatal lethality in mice expressing RIPK1 with mutated RHIM (Ripk1(mR/mR)), skin inflammation in mice with epidermis-specific RIPK1 deficiency (RIPK1(E-KO)) and colitis in mice with intestinal epithelial-specific FADD deficiency (FADD(IEC-KO)). Consistently, functional Z alpha domains were required for ZBP1-induced necroptosis in fibroblasts that were treated with caspase inhibitors or express RIPK1 with mutated RHIM. Inhibition of nuclear export triggered the Z alpha-dependent activation of RIPK3 in the nucleus resulting in cell death, which suggests that ZBP1 may recognize nuclear Z-form nucleic acids. We found that ZBP1 constitutively bound cellular double-stranded RNA in a Z alpha-dependent manner. Complementary reads derived from endogenous retroelements were detected in epidermal RNA, which suggests that double-stranded RNA derived from these retroelements may act as a Z alpha-domain ligand that triggers the activation of ZBP1. Collectively, our results provide evidence that the sensing of endogenous Z-form nucleic acids by ZBP1 triggers RIPK3-dependent necroptosis and inflammation, which could underlie the development of chronic inflammatory conditions-particularly in individuals with mutations in RIPK1 and CASP8(17-20).