GSTDTAP

浏览/检索结果: 共31条,第1-10条 帮助

限定条件    
已选(0)清除 条数/页:   排序方式:
Impact of topography on black carbon transport to the southern Tibetan Plateau during the pre-monsoon season and its climatic implication 期刊论文
ATMOSPHERIC CHEMISTRY AND PHYSICS, 2020, 20 (10) : 5923-5943
作者:  Zhang, Meixin;  Zhao, Chun;  Cong, Zhiyuan;  Du, Qiuyan;  Xu, Mingyue;  Chen, Yu;  Chen, Ming;  Li, Rui;  Fu, Yunfei;  Zhong, Lei;  Kang, Shichang;  Zhao, Delong;  Yang, Yan
收藏  |  浏览/下载:17/0  |  提交时间:2020/05/20
Oncometabolites suppress DNA repair by disrupting local chromatin signalling 期刊论文
NATURE, 2020
作者:  Zhang, Xu;  Lei, Bo;  Yuan, Yuan;  Zhang, Li;  Hu, Lu;  Jin, Sen;  Kang, Bilin;  Liao, Xuebin;  Sun, Wenzhi;  Xu, Fuqiang;  Zhong, Yi;  Hu, Ji;  Qi, Hai
收藏  |  浏览/下载:23/0  |  提交时间:2020/07/03

Metabolites that are elevated in tumours inhibit the lysine demethylase KDM4B, resulting in aberrant hypermethylation of histone 3 lysine 9 and decreased homology-dependent DNA repair.


Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer(1). Increased levels of the metabolites 2-hydroxyglutarate, succinate and fumarate occur in human malignancies owing to somatic mutations in the isocitrate dehydrogenase-1 or -2 (IDH1 or IDH2) genes, or germline mutations in the fumarate hydratase (FH) and succinate dehydrogenase genes (SDHA, SDHB, SDHC and SDHD), respectively(2-4). Recent work has made an unexpected connection between these metabolites and DNA repair by showing that they suppress the pathway of homology-dependent repair (HDR)(5,6) and confer an exquisite sensitivity to inhibitors of poly (ADP-ribose) polymerase (PARP) that are being tested in clinical trials. However, the mechanism by which these oncometabolites inhibit HDR remains poorly understood. Here we determine the pathway by which these metabolites disrupt DNA repair. We show that oncometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethylation of histone 3 lysine 9 (H3K9) at loci surrounding DNA breaks, masking a local H3K9 trimethylation signal that is essential for the proper execution of HDR. Consequently, recruitment of TIP60 and ATM, two key proximal HDR factors, is substantially impaired at DNA breaks, with reduced end resection and diminished recruitment of downstream repair factors. These findings provide a mechanistic basis for oncometabolite-induced HDR suppression and may guide effective strategies to exploit these defects for therapeutic gain.


  
Regional Differences of Chemical Composition and Optical Properties of Aerosols in the Tibetan Plateau 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2020, 125 (1)
作者:  Xu, Jianzhong;  Hettiyadura, Anusha Priyadarshani Silva;  Liu, Yanmei;  Zhang, Xinghua;  Kang, Shichang;  Laskin, Alexander
收藏  |  浏览/下载:5/0  |  提交时间:2020/07/02
VDAC oligomers form mitochondrial pores to release mtDNA fragments and promote lupus-like disease 期刊论文
SCIENCE, 2019, 366 (6472) : 1531-+
作者:  Kim, Jeonghan;  Gupta, Rajeev;  Blanco, Luz P.;  Yang, Shutong;  Shteinfer-Kuzmine, Anna;  Wang, Kening;  Zhu, Jun;  Yoon, Hee Eun;  Wang, Xinghao;  Kerkhofs, Martijn;  Kang, Hyeog;  Brown, Alexandra L.;  Park, Sung-Jun;  Xu, Xihui;  van Rilland, Eddy Zandee;  Kim, Myung K.;  Cohen, Jeffrey I.;  Kaplan, Mariana J.;  Shoshan-Barmatz, Varda;  Chung, Jay H.
收藏  |  浏览/下载:14/0  |  提交时间:2020/02/17
The Large-Scale Circulation Patterns Responsible for Extreme Precipitation Over the North China Plain in Midsummer 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019, 124 (23) : 12794-12809
作者:  Zhao, Yang;  Xu, Xiangde;  Li, Jiao;  Zhang, Rong;  Kang, Yanzhen;  Huang, Wubin;  Xia, Yu;  Liu, Di;  Sun, Xiaoyun
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
A New Method for Distinguishing Unactivated Particles in Cloud Condensation Nuclei Measurements: Implications for Aerosol Indirect Effect Evaluation 期刊论文
GEOPHYSICAL RESEARCH LETTERS, 2019, 46 (23) : 14185-14194
作者:  Wang, Yuan;  Niu, Shengjie;  Lv, Jingjing;  Lu, Chunsong;  Xu, Xiaoqi;  Wang, Yuying;  Ding, Jie;  Zhang, Hongwei;  Wang, Tianshu;  Kang, Boshi
收藏  |  浏览/下载:18/0  |  提交时间:2020/02/17
cloud condensation nuclei (CCN)  unactivated particles  kappa-Kohler theory  CCN activation parameterizations  aerosol indirect effects  
The Large-Scale Circulation Patterns Responsible for Extreme Precipitation Over the North China Plain in Midsummer 期刊论文
JOURNAL OF GEOPHYSICAL RESEARCH-ATMOSPHERES, 2019
作者:  Zhao, Yang;  Xu, Xiangde;  Li, Jiao;  Zhang, Rong;  Kang, Yanzhen;  Huang, Wubin;  Xia, Yu;  Liu, Di;  Sun, Xiaoyun
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
The effect of green space behaviour and per capita area in small urban green spaces on psychophysiological responses 期刊论文
LANDSCAPE AND URBAN PLANNING, 2019, 192
作者:  Lin, Wei;  Chen, Qibing;  Jiang, Mingyan;  Zhang, Xiaoxia;  Liu, Zongfang;  Tao, Jinying;  Wu, Linjia;  Xu, Shan;  Kang, Yushan;  Zeng, Qiuyuan
收藏  |  浏览/下载:10/0  |  提交时间:2020/02/17
El Nino-East Asian monsoon teleconnection and its diversity in CMIP5 models 期刊论文
CLIMATE DYNAMICS, 2019, 53: 6417-6435
作者:  Wang, Peng;  Tam, Chi-Yung;  Xu, Kang
收藏  |  浏览/下载:1/0  |  提交时间:2019/11/27
Eastern-Pacific El Nino  Central-Pacific El Nino  East Asian summer monsoon  El Nino-EASM teleconnection  CMIP5  
Precessional Forced Zonal Triple-Pole Anomalies in the Tropical Pacific Annual Cycle 期刊论文
JOURNAL OF CLIMATE, 2019, 32 (21) : 7369-7402
作者:  Wang, Yue;  Jian, Zhimin;  Zhao, Ping;  Xu, Kang;  Dang, Haowen;  Liu, Zhongfang;  Xiao, Dong;  Chen, Junming
收藏  |  浏览/下载:15/0  |  提交时间:2019/11/27
Paleoclimate